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Title:
RAPID TUMORIGENICITY SCREENING SYSTEM
Document Type and Number:
WIPO Patent Application WO/2019/026903
Kind Code:
A1
Abstract:
The present invention provides a method for evaluating the tumorigenicity of test cells, the method including transplanting the cells into the anterior chamber of an experimental animal and observing the presence/absence of tumor formation. The present invention enables a rapid and convenient evaluation of tumorigenicity.

Inventors:
SHIMMURA SHIGETO (JP)
HATOU SHIN (JP)
INAGAKI EMI (JP)
TSUBOTA KAZUO (JP)
Application Number:
PCT/JP2018/028654
Publication Date:
February 07, 2019
Filing Date:
July 31, 2018
Export Citation:
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Assignee:
UNIV KEIO (JP)
International Classes:
G01N33/48; C12N5/09; C12N5/095; C12Q1/02; G01N33/15; G01N33/50; A61K35/13; A61K35/545; A61P43/00
Foreign References:
JP2017148605A2017-08-31
Other References:
OGAWA, MITSUHIDE ET AL.: "P-03-034 [Review about non- clinical tumorigenicity examination using human mesenchymal stem cell and HeLa cell]", REGENERATIVE MEDICINE, vol. 16, 1 February 2017 (2017-02-01), pages 431, XP009519103, ISSN: 1347-7919
HATO, SHIN ET AL.: "Method for injecting and transplanting iPS cell -derived cornea endothelial substitute cells into anterior chamber", REGENERATIVE MEDICINE, vol. 14, 1 February 2015 (2015-02-01), pages 236, XP009519102, ISSN: 1347-7919
"Requirements for Use of Animal Cells as in vitro Substrates for the Production of Biologicals", WHO EXPERT COMMITTEE ON BIOLOGICAL STANDARDIZATION, 47TH REPORT, 1998
CELL MED., vol. 3, 2012, pages 103 - 112
EXP. ANIM., vol. 63, no. 1, 2014, pages 55 - 62
PLOS ONE, vol. 9, no. 1, 2014, pages e106110
CYTOTHERAPY, vol. 15, 2013, pages 578 - 585
See also references of EP 3663757A4
Attorney, Agent or Firm:
TAKASHIMA, Hajime et al. (JP)
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