Title:
RARE EARTH COMPLEX, OPTICAL IMAGING AGENT FOR RADIATION THERAPY, SCINTILLATOR FOR NEUTRON DETECTION, AND CARBORANE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2020/004656
Kind Code:
A1
Abstract:
Provided is a rare earth complex which comprises one or more trivalent rare earth ions and a plurality of ligands coordinating to the rare earth ions. The plurality of ligands includes: a first ligand which has a carborane group and a coordinating group that is bonded to a carbon atom of the carborane group and is capable of coordinating to the rare earth ions; and a second ligand which has a photosensitizing action.
Inventors:
HASEGAWA YASUCHIKA (JP)
SAITO KOUKI (JP)
KITAGAWA YUICHI (JP)
NAKANISHI TAKAYUKI (JP)
FUSHIMI KOJI (JP)
SAITO KOUKI (JP)
KITAGAWA YUICHI (JP)
NAKANISHI TAKAYUKI (JP)
FUSHIMI KOJI (JP)
Application Number:
PCT/JP2019/025964
Publication Date:
January 02, 2020
Filing Date:
June 28, 2019
Export Citation:
Assignee:
UNIV HOKKAIDO NAT UNIV CORP (JP)
International Classes:
C07F5/02; A61K51/04; C07D471/04; C07F9/53; G01N21/64; C07F5/00
Foreign References:
| JP2005519988A | 2005-07-07 | |||
| US5955586A | 1999-09-21 |
Other References:
TOPPINO, ANTONIO ET AL.: "A Carborane-Derivative ''Click'' Reaction under Heterogeneous Conditions for the Synthesis of a Promising Lipophilic MRI/GdBNCT Agent", CHEMISTRY - A EUROPEAN JOURNAL, vol. 19, no. 2, 2013, pages 721 - 728, XP002766953
GENINATTI-CRICH, ''SIMONETTA ET AL.: "MRI-Guided Neutron Capture Therapy by Use of a Dual Gadolinium/Boron Agent Targeted at Tumour Cells through Upregulated Low-Density Lipoprotein", CHEMISTRY - A EUROPEAN JOURNAL, vol. 17, no. 30, 2011, pages 8479 - 8486, XP055666944
YAMAMOTO, YOSHINORI: "Boron-gadolinium binary system as a magnetic resonance imaging boron carrier", PURE AND APPLIED CHEMISTRY, vol. 75, no. 9, 2003, pages 1343 - 1348, XP055666951
POPESCU, ADRIAN-RADU ET AL.: "Uncommon Coordination Behaviour of P (S) and P (Se) Units when Bonded to Carboranyl Clusters:Experimental and Computational Studies on the Oxidation of Carboranyl Phosphine Ligands", CHEMISTRY - A EUROPEAN JOURNAL, vol. 17, no. 16, 2011, pages 4429 - 4443
GENINATTI-CRICH, ''SIMONETTA ET AL.: "MRI-Guided Neutron Capture Therapy by Use of a Dual Gadolinium/Boron Agent Targeted at Tumour Cells through Upregulated Low-Density Lipoprotein", CHEMISTRY - A EUROPEAN JOURNAL, vol. 17, no. 30, 2011, pages 8479 - 8486, XP055666944
YAMAMOTO, YOSHINORI: "Boron-gadolinium binary system as a magnetic resonance imaging boron carrier", PURE AND APPLIED CHEMISTRY, vol. 75, no. 9, 2003, pages 1343 - 1348, XP055666951
POPESCU, ADRIAN-RADU ET AL.: "Uncommon Coordination Behaviour of P (S) and P (Se) Units when Bonded to Carboranyl Clusters:Experimental and Computational Studies on the Oxidation of Carboranyl Phosphine Ligands", CHEMISTRY - A EUROPEAN JOURNAL, vol. 17, no. 16, 2011, pages 4429 - 4443
Attorney, Agent or Firm:
HASEGAWA Yoshiki et al. (JP)
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