INTERNATIONAL SEARCH REPORT International application No. PCTsIJS00/2823 1 C (Continuation). DOCUMENTS CONSIDERED TO BE RELEVANT Category* Citation of document. with indication, where appropriate, of the relevant passages Relevant to claim No. P, A US 6,130,067 A (TSUI, P.) 10 October 2000, col. 6-7.6-10 INTERNATIONAL SEARCH REPORT Intemational application No. PCT/US00/28231 zox I Observations where certain claims were found unsearchable (Continuation of item 1 of first sheet) This international report has not been established in respect of certain claims under Article 17 (2Xa) for the following reasons: 1. n Claims Nos. : I because thev relate to subject matter not required to be searched by this Authority. namely : 2. ! Claims Nos.: because they relate to parts of the international application that do not comply with the prescribed requirements to such an extent that no meaningful intemational search can be carried out, specifically : 3. f Claims Nos.: because they are dependent claims and are not drafted in accordance with the second and third sentences of Rule 6.4 (a). Box 11 Observations where unity of invention is lacking (Continuation of item 2 of first sheet) This International Searching Authority found muitiple inventions in this international application, as follows : Please See Extra Sheet. ) ! ! As all required additional search fees . vere timely paid by the applicant, this intemational search report covers all searchable claims. 2. g As all searchable claims could be searched without effort justifying an additional tee. this Authority did not invite payment of anv additional tee 3. As on) y some ot the required additional search fees were timelv paid by the applicant, this international search report covers only those claims for which tees xnere paid. specifically claims Nos.: 4. n No required additional search tees were timely paid bs the applicant. Consequently. this intemational search report is restricted to the invention first mentioned in the claims : it is covered by claims Nos.: 1-2 and 6-10 Remark on Protest The additional search tees were accompanied bv the applicant's protest. No protest accompanied the paument ot additional search tees INTERNATIONAL SEARCH REPORT International application No. PCT,'LJSOO/28231 BOX 11. OBSERVATIONS WHERE UNITY OF INVENTION WAS LACKING This ISA found multiple inventions as follosrs : This application contains the following inventions or groups of inventions which are not so linked as to form a single inventive concept under PCT Rule 13. 1. In order for all inventions to be searched, the appropriate additional search fees must be paid. Group 1. claim (s) 1-2 and 6-10. drawn to polypeptides. polynucleotides encoding such, vectors thereof, host cells, and recombinant expression and purification of such. Group II. claim (s) 3, drawn to a method for screening to identify compounds. Group III, claim (s) 4-5. drawn to an agonist or an antagonist of the polypeptide. The inventions listed as Groups I-III do not relate to a single inventive concept under PCT Rule 13.1 because, under PCT Rule 13. 2, they lack the same or corresponding special technical features for the following reasons: This authority considers that the main invention in the instant application comprises the first-recited product, polvnucleotide encoding Rattus Norvegicus EDG3. and the first-recited method of using that product, namely in the process of producing the encoded pohpeptide Note that there is no method of making the polynucleotide. Also included in this group is the product made. namely the encoded polypeptide, the vector and host cell comprising the polynucleotide. The materially and functionallv dissimilar products of group III and the additional method of group II do not share a special technical feature within the meaning of PCT Rule 13. 2 and thus do not relate to a single invention concept within the meaning of PCT Rule 13. 1