Title:
RATTUS NORVEGICUS (EDG3)
Document Type and Number:
WIPO Patent Application WO2001027137
Kind Code:
A3
Abstract:
Rattus norvegicus EDG3 polypeptides and polynucleotides and method for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for screening for compounds which either agonize or antagonize Rattus norvegicus EDG3. Such compounds are expected to be useful in treatment of human diseases, including, but not limited to: infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; pain; cancers; diabetes, obesity; anorexia; bulimia; asthma; Parkinson's disease; acute heart failure; hypotension; hypertension; urinary retention; osteoporosis; angina pectoris; myocardial infarction; stroke; ulcers, asthma; allergies; benign prostatic hypertrophy; migraine; vomiting; psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, depression, dementia, and severe mental retardation; and dyskinesias, such as Huntington's disease or Gilles de la Tourett's syndrome.
Inventors:
LANE PAMELA
TSUI PING
ELSHOURBAGY NABIL
TSUI PING
ELSHOURBAGY NABIL
Application Number:
PCT/US2000/028231
Publication Date:
June 07, 2001
Filing Date:
October 12, 2000
Export Citation:
Assignee:
SMITHKLINE BEECHAM CORP (US)
SMITHKLINE BEECHAM PLC (GB)
SMITHKLINE BEECHAM PLC (GB)
International Classes:
C07K14/705; (IPC1-7): C07H21/00; C07K14/00; C12N15/09
Foreign References:
| US5912144A | 1999-06-15 | |||
| US6130067A | 2000-10-10 |
Other References:
ZHANG G. ET AL.: "Comparative analysis of three murine G-protein coupled receptors activated by sphingosine-1- phosphate", GENE, vol. 227, February 1999 (1999-02-01), pages 89 - 99
DATABASE GENBANK [online] 26 September 1999 (1999-09-26), NAKAJIMA N. ET AL., Database accession no. AF184914
DATABASE GENBANK [online] 27 November 1997 (1997-11-27), MARRIA M. ET AL., Database accession no. AA672296
DATABASE GENBANK [online] 8 September 1998 (1998-09-08), MARRA M. ET AL., Database accession no. AI115954
DATABASE GENBANK [online] 26 September 1999 (1999-09-26), NAKAJIMA N. ET AL., Database accession no. AF184914
DATABASE GENBANK [online] 27 November 1997 (1997-11-27), MARRIA M. ET AL., Database accession no. AA672296
DATABASE GENBANK [online] 8 September 1998 (1998-09-08), MARRA M. ET AL., Database accession no. AI115954
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