Title:
REACTION VESSEL FOR LABELING BIOLOGICAL MOLECULE, AND REACTION APPARATUS AND REACTION METHOD EACH USING SAME
Document Type and Number:
WIPO Patent Application WO/2014/102944
Kind Code:
A1
Abstract:
Provided are: a reaction vessel whereby it becomes possible to accelerate the progression of a labeling reaction while keeping the function of a biological molecule and to select a mixing time while taking into account the attenuation of a labeling agent; and a reaction apparatus equipped with the reaction vessel.
A reaction vessel for mixing a first compound that is a biological molecule with a second compound that is a labeling agent. The reaction vessel is equipped with a reaction vessel main body and a lid member so arranged as to face the surface side of the reaction vessel main body, wherein a flow path is formed on the surface of the reaction vessel main body, a labeling agent solidification section for removing a solvent from a solution of the second compound to solidify the second compound is formed in the middle of the flow path, a supply section for the first compound and a supply section for the second compound are formed on the upstream side of the labeling agent solidification section, and the discharge section for the mixture is formed on the downstream side of the labeling agent solidification section. The reaction apparatus is equipped with a liquid supply unit for supplying the first compound and the second compound to the reaction vessel and for supplying a solution of the first compound to the upper part of the second compound solidified in the solidification section while moving back and forth.
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Inventors:
SUGITA NAMI (JP)
MANRI NAOMI (JP)
TAKEUCHI WATARU (JP)
MORIMOTO YUICHI (JP)
HANZAWA HIROKO (JP)
MANRI NAOMI (JP)
TAKEUCHI WATARU (JP)
MORIMOTO YUICHI (JP)
HANZAWA HIROKO (JP)
Application Number:
PCT/JP2012/083744
Publication Date:
July 03, 2014
Filing Date:
December 26, 2012
Export Citation:
Assignee:
HITACHI LTD (JP)
International Classes:
C07B59/00; B01J19/00; G01N37/00
Domestic Patent References:
| WO2012027527A2 | 2012-03-01 |
Foreign References:
| JP2010235462A | 2010-10-21 | |||
| JP2010531295A | 2010-09-24 | |||
| JP2007136280A | 2007-06-07 | |||
| JP2003315337A | 2003-11-06 | |||
| JP2008128906A | 2008-06-05 |
Other References:
W-Y TSENG ET AL.: "Toward reliable synthesis of radiotracers for positron emission tomography in PDMS microfluidic chips: Study and optimization of the [18F] fluoride drying process", TECHNICAL PROCEEDINGS OF THE 2010 NSTI NANOTECHNOLOGY CONFERENCE & EXPO - NANOTECH, vol. 2, 2010, pages 472 - 475
RALF SCHIRRMACHER ET AL.: "Recent Developments and Trends in 18F-Radiochemistry: Syntheses andApplications", MINI-REVIEWS IN ORGANIC CHEMISTRY, vol. 4, 2007, pages 317 - 329, XP002559050, DOI: doi:10.2174/157019307782411699
RALF SCHIRRMACHER ET AL.: "Recent Developments and Trends in 18F-Radiochemistry: Syntheses andApplications", MINI-REVIEWS IN ORGANIC CHEMISTRY, vol. 4, 2007, pages 317 - 329, XP002559050, DOI: doi:10.2174/157019307782411699
Attorney, Agent or Firm:
POLAIRE I. P. C. (JP)
Polaire Intellectual Property Corporation (JP)
Polaire Intellectual Property Corporation (JP)
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