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Patent Searching and Data


Title:
READTHROUGH INDUCER AND PHARMACEUTICAL USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/225625
Kind Code:
A1
Abstract:
The present invention pertains to a compound represented by general formula (I) [the symbols in the formula are as described in the specification] or a pharmacologically acceptable salt thereof, and to a pharmaceutical composition containing said compound as an active ingredient. Because the abovementioned compound has readthrough activity, the present invention makes it possible to provide a medicine useful as an agent for the prevention or treatment of nonsense mutation-type genetic diseases such as mucopolysaccharidosis, muscular dystrophy, Duchenne muscular dystrophy, multiple sclerosis, cystic fibrosis, ceroid lipofuscinosis, and Neiman-Pick disease.

Inventors:
TAKEDA SHIGEMITSU (JP)
SHIRAHASE HIROAKI (JP)
TAKASHIMA SHUNSUKE (JP)
KITAO TATSUYA (JP)
Application Number:
JP2019/020189
Publication Date:
November 28, 2019
Filing Date:
May 22, 2019
Export Citation:
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Assignee:
KYOTO PHARMA IND (JP)
International Classes:
C07D491/052; A61K31/436; A61K31/437; A61K31/4375; A61K31/444; A61K31/4545; A61K31/497; A61K31/5377; A61K31/55; A61K31/551; A61K31/553; A61K31/675; A61P3/00; A61P21/00; A61P43/00; C07D491/147; C07D498/14; C07F7/18; C07F9/655
Domestic Patent References:
WO2018186365A12018-10-11
Foreign References:
JP2017516821A2017-06-22
JP2017516828A2017-06-22
JP2017516829A2017-06-22
JP2016503003A2016-02-01
JPS50101396A1975-08-11
Attorney, Agent or Firm:
TAKASHIMA, Hajime (JP)
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