Title:
REAGENT COMBINATION AND KIT FOR DETECTING LIVER CANCERS, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/105774
Kind Code:
A1
Abstract:
A reagent combination for detecting liver cancers. The reagent combination comprises any one of the following detection reagents: 1) a detection reagent for detecting the methylation level of at least one of the following methylation sites of the PAK1 gene: cg17202086, cg26996201, and cg18309286; 2) a detection reagent for detecting the methylation level of at least one of the following methylation sites of the OTX1 gene: cg23229261 and cg10122865; and 3) a detection reagent for detecting the methylation level of methylation site cg16657538 of the ZNF397OS gene. Further provided are the use of the reagent combination, and a kit comprising the reagent combination.
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Inventors:
DAI LIZHONG (CN)
CHEN MING (CN)
GUO XINWU (CN)
HONG MEI (CN)
LIU JIA (CN)
LIU RANGJIAO (CN)
CHEN MING (CN)
GUO XINWU (CN)
HONG MEI (CN)
LIU JIA (CN)
LIU RANGJIAO (CN)
Application Number:
PCT/CN2021/131103
Publication Date:
May 27, 2022
Filing Date:
November 17, 2021
Export Citation:
Assignee:
SANSURE BIOTECH INC (CN)
International Classes:
C12Q1/6886
Foreign References:
| CN112280865A | 2021-01-29 | |||
| CN112322736A | 2021-02-05 | |||
| CN112501293A | 2021-03-16 | |||
| CN107164508A | 2017-09-15 | |||
| CN110904225A | 2020-03-24 | |||
| CN106947830A | 2017-07-14 | |||
| CN1659287A | 2005-08-24 | |||
| CN106947830A | 2017-07-14 |
Other References:
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SONG, M.A. ET AL.: "Elucidating the Landscape of Aberrant DNA Methylation in Hepatocellular Carcinoma", PLOS ONE, vol. 8, no. 2, 20 February 2013 (2013-02-20), XP055173243, DOI: 10.1371/journal.pone.0055761
XIANG‐JUN SUN, WANG MING‐CHUN, ZHANG FENG‐HUA, KONG XIAO: "An integrated analysis of genome-wide DNA methylation and gene expression data in hepatocellular carcinoma", FEBS OPEN BIO, ELSEVIER, US, vol. 8, no. 7, 1 July 2018 (2018-07-01), US , pages 1093 - 1103, XP055737543, ISSN: 2211-5463, DOI: 10.1002/2211-5463.12433
SHEN, JING ET AL.: "Exploring genome-wide DNA methylation profiles altered in hepatocellular carcinoma using Infinium HumanMethylation 450 BeadChips", EPIGENETICS, vol. 8, no. 1, 31 January 2013 (2013-01-31), XP055900823, DOI: 10.4161/epi.23062
WU HUI-CHEN, SHEN JING, YANG HWAI-I, TSAI WEI-YANN, CHEN CHIEN-JEN, SANTELLA REGINA M, WU HUI-CHEN, HERBERT: "Blood DNA methylation markers in prospectively identified hepatocellular carcinoma cases and controls from Taiwan", WORLD JOURNAL OF HEPATOLOGY, vol. 8, no. 5, 1 January 2016 (2016-01-01), pages 301, XP055932081, ISSN: 1948-5182, DOI: 10.4254/wjh.v8.i5.301
XU RHWEI WKRAWCZYK MWANG WLUO HFLAGG K ET AL.: "Circulating tumor DNA methylation markers for diagnosis and prognosis for diagnosis and prognosis of hepatocellular carcinoma", NATURE MATERIALS, 2017
SONG, M.A. ET AL.: "Elucidating the Landscape of Aberrant DNA Methylation in Hepatocellular Carcinoma", PLOS ONE, vol. 8, no. 2, 20 February 2013 (2013-02-20), XP055173243, DOI: 10.1371/journal.pone.0055761
XIANG‐JUN SUN, WANG MING‐CHUN, ZHANG FENG‐HUA, KONG XIAO: "An integrated analysis of genome-wide DNA methylation and gene expression data in hepatocellular carcinoma", FEBS OPEN BIO, ELSEVIER, US, vol. 8, no. 7, 1 July 2018 (2018-07-01), US , pages 1093 - 1103, XP055737543, ISSN: 2211-5463, DOI: 10.1002/2211-5463.12433
SHEN, JING ET AL.: "Exploring genome-wide DNA methylation profiles altered in hepatocellular carcinoma using Infinium HumanMethylation 450 BeadChips", EPIGENETICS, vol. 8, no. 1, 31 January 2013 (2013-01-31), XP055900823, DOI: 10.4161/epi.23062
WU HUI-CHEN, SHEN JING, YANG HWAI-I, TSAI WEI-YANN, CHEN CHIEN-JEN, SANTELLA REGINA M, WU HUI-CHEN, HERBERT: "Blood DNA methylation markers in prospectively identified hepatocellular carcinoma cases and controls from Taiwan", WORLD JOURNAL OF HEPATOLOGY, vol. 8, no. 5, 1 January 2016 (2016-01-01), pages 301, XP055932081, ISSN: 1948-5182, DOI: 10.4254/wjh.v8.i5.301
XU RHWEI WKRAWCZYK MWANG WLUO HFLAGG K ET AL.: "Circulating tumor DNA methylation markers for diagnosis and prognosis for diagnosis and prognosis of hepatocellular carcinoma", NATURE MATERIALS, 2017
Attorney, Agent or Firm:
CHINA PAT INTELLECTUAL PROPERTY OFFICE (CN)
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