Title:
REAGENT FOR DIAGNOSING AND TREATING TUMOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/237621
Kind Code:
A1
Abstract:
A reagent for diagnosing and treating a tumor and the use thereof. Provided is the use of an inhibitor of FBXW2 in preparation of a drug for preventing or treating a cancer and inhibiting growth of tumor cells. Disclosed is the function of an FBXW2 proto-oncogene. A new strategy is provided for clinical treatment.
Inventors:
GAO DAMING (CN)
LI LONG (CN)
LI LONG (CN)
Application Number:
PCT/CN2022/091005
Publication Date:
November 17, 2022
Filing Date:
May 05, 2022
Export Citation:
Assignee:
CENTER FOR EXCELLENCE IN MOLECULAR CELL SCIENCE CHINESE ACAD OF SCIENCES (CN)
International Classes:
A61K45/00; A61K31/365; A61K31/438; A61K31/7088; A61K39/395; A61P35/00; C12Q1/6886; G01N33/574
Foreign References:
| CN105147667A | 2015-12-16 | |||
| CN111728997A | 2020-10-02 |
Other References:
YIN YUAN, XIE CHUAN-MING, LI HUA, TAN MINGJIA, CHEN GUOAN, SCHIFF RACHEL, XIONG XIUFANG, SUN YI: "The FBXW2–MSX2–SOX2 axis regulates stem cell property and drug resistance of cancer cells", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, vol. 116, no. 41, 8 October 2019 (2019-10-08), pages 20528 - 20538, XP093004194, ISSN: 0027-8424, DOI: 10.1073/pnas.1905973116
YANG FEI, XU JIE, LI HUA, TAN MINGJIA, XIONG XIUFANG, SUN YI: "FBXW2 suppresses migration and invasion of lung cancer cells via promoting β-catenin ubiquitylation and degradation", NATURE COMMUNICATIONS, vol. 10, no. 1, 1 December 2019 (2019-12-01), XP093004195, DOI: 10.1038/s41467-019-09289-5
WANG CHENG, XU WENJING, CHAO YUELIN, LIANG MINGLU, ZHANG FENGXIAO, HUANG KAI: "E3 Ligase FBXW2 Is a New Therapeutic Target in Obesity and Atherosclerosis", ADVANCED SCIENCE, vol. 7, no. 20, 1 October 2020 (2020-10-01), pages 2001800, XP093004196, ISSN: 2198-3844, DOI: 10.1002/advs.202001800
YANG FEI, XU JIE, LI HUA, TAN MINGJIA, XIONG XIUFANG, SUN YI: "FBXW2 suppresses migration and invasion of lung cancer cells via promoting β-catenin ubiquitylation and degradation", NATURE COMMUNICATIONS, vol. 10, no. 1, 1 December 2019 (2019-12-01), XP093004195, DOI: 10.1038/s41467-019-09289-5
WANG CHENG, XU WENJING, CHAO YUELIN, LIANG MINGLU, ZHANG FENGXIAO, HUANG KAI: "E3 Ligase FBXW2 Is a New Therapeutic Target in Obesity and Atherosclerosis", ADVANCED SCIENCE, vol. 7, no. 20, 1 October 2020 (2020-10-01), pages 2001800, XP093004196, ISSN: 2198-3844, DOI: 10.1002/advs.202001800
Attorney, Agent or Firm:
SHANGHAI PATENT & TRADEMARK LAW OFFICE, LLC (CN)
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