Title:
REAGENT FOR MEASURING ACTIVE NITROGEN
Document Type and Number:
WIPO Patent Application WO/2010/064443
Kind Code:
A1
Abstract:
Disclosed is a compound which is useful for measuring active nitrogen species occurring in a cell, such as nitric oxide and peroxynitrite, with high sensitivity for a long period. The compound is represented by general formula (I) [wherein R1 and R2 represent amino groups that are substituents to be located in adjacent positions to each other on a benzene ring; R3 and R4 independently represent a halogen atom; R5 and R6 independently represent a hydrogen atom, an acyl group or an acyloxy-(C1-6-alkyl) group; and R7 and R8 independently represent a group represented by -(CH2)p-N(R9)(R10) (wherein p represents 1 to 4, and R9 and R10 independently represent -(CH2)n-COOH wherein n represents 1 to 4)].
Inventors:
NAGANO TETSUO (JP)
URANO YASUTERU (JP)
IZUMI SAKI (JP)
URANO YASUTERU (JP)
IZUMI SAKI (JP)
Application Number:
PCT/JP2009/006616
Publication Date:
June 10, 2010
Filing Date:
December 04, 2009
Export Citation:
Assignee:
UNIV TOKYO (JP)
NAGANO TETSUO (JP)
URANO YASUTERU (JP)
IZUMI SAKI (JP)
NAGANO TETSUO (JP)
URANO YASUTERU (JP)
IZUMI SAKI (JP)
International Classes:
G01N33/52; G01N21/78; G01N31/00; G01N31/22
Domestic Patent References:
| WO2002018362A1 | 2002-03-07 | |||
| WO2006093252A1 | 2006-09-08 |
Foreign References:
| JPH10226688A | 1998-08-25 | |||
| JP2003130797A | 2003-05-08 | |||
| JPH0943153A | 1997-02-14 | |||
| JP2003277385A | 2003-10-02 |
Other References:
SAKI IZUMI ET AL.: "Saibonai Tairyusei o Kaizen shita, Shinki hROS Kenshutsu Keiko Probe no Kaihatsu", SYMPOSIUM ON BIOMEDICAL-ANALYTICAL SCIENCES KOEN YOSHISHU, vol. 21, 1 August 2008 (2008-08-01), pages 35 - 36
SAKI IZUMI ET AL.: "A Simple and Effective Strategy To Increase the Sensitivity of Fluorescence Probes in Living Cells", J. AM. CHEM. SOC., vol. 131, no. 29, 2 July 2009 (2009-07-02), pages 10189 - 10200
SAKI IZUMI ET AL.: "A Simple and Effective Strategy To Increase the Sensitivity of Fluorescence Probes in Living Cells", J. AM. CHEM. SOC., vol. 131, no. 29, 2 July 2009 (2009-07-02), pages 10189 - 10200
Attorney, Agent or Firm:
SIKs & Co. (JP)
Patent business corporation patent firm Sykes (JP)
Patent business corporation patent firm Sykes (JP)
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