Title:
REAGENTS AND METHODS FOR MODULATING CONE PHOTORECEPTOR ACTIVITY
Document Type and Number:
WIPO Patent Application WO/2011/034947
Kind Code:
A3
Abstract:
The present invention provides reagents and methods for modulating cone photoreceptor activity, and devices for assessment of cone photoreceptor activity.
Inventors:
NEITZ JAY (US)
NEITZ MAUREEN (US)
KUCHENBECKER JAMES A (US)
NEITZ MAUREEN (US)
KUCHENBECKER JAMES A (US)
Application Number:
PCT/US2010/048964
Publication Date:
September 29, 2011
Filing Date:
September 15, 2010
Export Citation:
Assignee:
UNIV WASHINGTON (US)
WISCONSIN MED COLLEGE INC (US)
NEITZ JAY (US)
NEITZ MAUREEN (US)
KUCHENBECKER JAMES A (US)
WISCONSIN MED COLLEGE INC (US)
NEITZ JAY (US)
NEITZ MAUREEN (US)
KUCHENBECKER JAMES A (US)
International Classes:
A61K48/00
Domestic Patent References:
| WO2002082904A2 | 2002-10-24 |
Other References:
MANCUSO K ET AL: "Progress in developing a gene therapy approach for treating color blindness", IOVS, vol. 46, no. Suppl. S, 2005, & ANNUAL MEETING OF THE ASSOCIATION-FOR-RESEARCH-IN-VISION-AND-OPHTHALM OLOGY; FT LAUDERDALE, FL, USA; MAY 01 -05, 2005, pages 4565, XP002615063, ISSN: 0146-0404
MANCUSO K ET AL: "Recombinant adeno-associated virus targets passenger gene expression to cones in primate retina", JOURNAL OF THE OPTICAL SOCIETY OF AMERICA A: OPTICS AND IMAGE SCIENCE, AND VISION MAY 2007 OPTICAL SOCIETY OF AMERICA US, vol. 24, no. 5, May 2007 (2007-05-01), pages 1411 - 1416, XP002615064, DOI: DOI:10.1364/JOSAA.24.001411
MAUCK MATTHEW C ET AL: "Longitudinal evaluation of expression of virally delivered transgenes in gerbil cone photoreceptors", VISUAL NEUROSCIENCE, vol. 25, no. 3, May 2008 (2008-05-01), pages 273 - 282, XP009140611, ISSN: 0952-5238
LI ET AL: "Cone-specific expression using a human red opsin promoter in recombinant AAV", VISION RESEARCH, PERGAMON PRESS, OXFORD, GB LNKD- DOI:10.1016/J.VISRES.2007.07.026, vol. 48, no. 3, 1 February 2008 (2008-02-01), pages 332 - 338, XP022452226, ISSN: 0042-6989
KUCHENBECKER JAMES A ET AL: "Topography of the long- to middle-wavelength sensitive cone ratio in the human retina assessed with a wide-field color multifocal electroretinogram", VISUAL NEUROSCIENCE, vol. 25, no. 3, May 2008 (2008-05-01), pages 301 - 306, XP009140612, ISSN: 0952-5238
CAI XUE ET AL: "Gene delivery to mitotic and postmitotic photoreceptors via compacted DNA nanoparticles results in improved phenotype in a mouse model of retinitis pigmentosa", FASEB JOURNAL, vol. 24, no. 4, April 2010 (2010-04-01), pages 1178 - 1191, XP002615066, ISSN: 0892-6638
KOMAROMY ANDRAS M ET AL: "Gene therapy rescues cone function in congenital achromatopsia", HUMAN MOLECULAR GENETICS, vol. 19, no. 13, July 2010 (2010-07-01), pages 2581 - 2593, XP002615067
MANCUSO KATHERINE ET AL: "Gene therapy for red-green colour blindness in adult primates", NATURE (LONDON), vol. 461, no. 7265, October 2009 (2009-10-01), pages 784, XP002615068, ISSN: 0028-0836
PANG ET AL: "Gene Therapy Restores Vision-Dependent Behavior as Well as Retinal Structure and Function in a Mouse Model of RPE65 Leber Congenital Amaurosis", MOLECULAR THERAPY, ACADEMIC PRESS, SAN DIEGO, CA, US, vol. 13, no. 3, 1 March 2006 (2006-03-01), pages 565 - 572, XP005326769, ISSN: 1525-0016, DOI: DOI:10.1016/J.YMTHE.2005.09.001
LAI ET AL: "The Clinical Applications of Multifocal Electroretinography: A Systematic Review", SURVEY OF OPHTHALMOLOGY, SURVEY OF OPHTHALMOLOGY INC, XX, vol. 52, no. 1, 6 January 2007 (2007-01-06), pages 61 - 96, XP005824590, ISSN: 0039-6257, DOI: DOI:10.1016/J.SURVOPHTHAL.2006.10.005
MANCUSO K ET AL: "Recombinant adeno-associated virus targets passenger gene expression to cones in primate retina", JOURNAL OF THE OPTICAL SOCIETY OF AMERICA A: OPTICS AND IMAGE SCIENCE, AND VISION MAY 2007 OPTICAL SOCIETY OF AMERICA US, vol. 24, no. 5, May 2007 (2007-05-01), pages 1411 - 1416, XP002615064, DOI: DOI:10.1364/JOSAA.24.001411
MAUCK MATTHEW C ET AL: "Longitudinal evaluation of expression of virally delivered transgenes in gerbil cone photoreceptors", VISUAL NEUROSCIENCE, vol. 25, no. 3, May 2008 (2008-05-01), pages 273 - 282, XP009140611, ISSN: 0952-5238
LI ET AL: "Cone-specific expression using a human red opsin promoter in recombinant AAV", VISION RESEARCH, PERGAMON PRESS, OXFORD, GB LNKD- DOI:10.1016/J.VISRES.2007.07.026, vol. 48, no. 3, 1 February 2008 (2008-02-01), pages 332 - 338, XP022452226, ISSN: 0042-6989
KUCHENBECKER JAMES A ET AL: "Topography of the long- to middle-wavelength sensitive cone ratio in the human retina assessed with a wide-field color multifocal electroretinogram", VISUAL NEUROSCIENCE, vol. 25, no. 3, May 2008 (2008-05-01), pages 301 - 306, XP009140612, ISSN: 0952-5238
CAI XUE ET AL: "Gene delivery to mitotic and postmitotic photoreceptors via compacted DNA nanoparticles results in improved phenotype in a mouse model of retinitis pigmentosa", FASEB JOURNAL, vol. 24, no. 4, April 2010 (2010-04-01), pages 1178 - 1191, XP002615066, ISSN: 0892-6638
KOMAROMY ANDRAS M ET AL: "Gene therapy rescues cone function in congenital achromatopsia", HUMAN MOLECULAR GENETICS, vol. 19, no. 13, July 2010 (2010-07-01), pages 2581 - 2593, XP002615067
MANCUSO KATHERINE ET AL: "Gene therapy for red-green colour blindness in adult primates", NATURE (LONDON), vol. 461, no. 7265, October 2009 (2009-10-01), pages 784, XP002615068, ISSN: 0028-0836
PANG ET AL: "Gene Therapy Restores Vision-Dependent Behavior as Well as Retinal Structure and Function in a Mouse Model of RPE65 Leber Congenital Amaurosis", MOLECULAR THERAPY, ACADEMIC PRESS, SAN DIEGO, CA, US, vol. 13, no. 3, 1 March 2006 (2006-03-01), pages 565 - 572, XP005326769, ISSN: 1525-0016, DOI: DOI:10.1016/J.YMTHE.2005.09.001
LAI ET AL: "The Clinical Applications of Multifocal Electroretinography: A Systematic Review", SURVEY OF OPHTHALMOLOGY, SURVEY OF OPHTHALMOLOGY INC, XX, vol. 52, no. 1, 6 January 2007 (2007-01-06), pages 61 - 96, XP005824590, ISSN: 0039-6257, DOI: DOI:10.1016/J.SURVOPHTHAL.2006.10.005
Attorney, Agent or Firm:
HARPER, David, S. (300 South Wacker Drive Suite 310, Chicago IL, US)
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