Title:
REAL-TIME FLUORESCENCE IMAGING SENSOR FOR MEASURING GLUTATHIONE IN ORGANELLE AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2019/039888
Kind Code:
A1
Abstract:
The present invention relates to a real-time fluorescence imaging sensor for measuring glutathione in organelles and a preparation method therefor. More particularly, the present invention relates to a novel compound for measuring glutathione in organelles, a method for preparing a novel compound, a real-time imaging sensor for measuring glutathione in organelles, the sensor comprising the novel compound, a preparation method therefor, and a method for measuring glutathione in organelles, using the imaging sensor. The use of a composition comprising the compound according to the present invention makes it possible to measure the antioxidant capacity of the organelles mitochondria or Golgi bodies in living cells, especially in the stem cell, allowing the selection of highly active stem cells on the basis of measurements of the antioxidant capacity of organelles.
Inventors:
KANG HEUN SOO (KR)
KIM HYE MI (KR)
SONG JI EUN (KR)
KIM MYOUNG JIN (KR)
CHOI KI HANG (KR)
KIM HYE MI (KR)
SONG JI EUN (KR)
KIM MYOUNG JIN (KR)
CHOI KI HANG (KR)
Application Number:
PCT/KR2018/009743
Publication Date:
February 28, 2019
Filing Date:
August 23, 2018
Export Citation:
Assignee:
CELL2IN INC (KR)
International Classes:
C07D491/147; A61K49/00; G01N21/64; G01N33/483; G01N33/50; G01N33/52
Foreign References:
| KR20160059978A | 2016-05-27 | |||
| CN103820104A | 2014-05-28 | |||
| US20170007723A1 | 2017-01-12 | |||
| KR101575846B1 | 2015-12-11 | |||
| KR20040030701A | 2004-04-09 |
Other References:
DATABASE Chemical Abstract 7 December 2001 (2001-12-07), retrieved from STN Database accession no. 374544-06-6
CHO, A. Y.: "A Coumarin-based Fluorescence Sensor for the Reversible Detection of Thiols", CHEM. LETT., 2012, pages 1611 - 1612, XP055309332, DOI: doi:10.1246/cl.2012.1611
LIU ET AL., CYTOTHERAPY, vol. 14, no. 2, 2012, pages 162 - 172
See also references of EP 3674305A4
CHO, A. Y.: "A Coumarin-based Fluorescence Sensor for the Reversible Detection of Thiols", CHEM. LETT., 2012, pages 1611 - 1612, XP055309332, DOI: doi:10.1246/cl.2012.1611
LIU ET AL., CYTOTHERAPY, vol. 14, no. 2, 2012, pages 162 - 172
See also references of EP 3674305A4
Attorney, Agent or Firm:
LEE, Jae Young (KR)
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