Title:
REAL-TIME MONITORING MITOPHAGY PROCESS BY FLUORESCENT PHOTOSTABLE MITOCHONDRIAL SPECIFIC BIOPROBE WITH AIE CHARACTERISTICS
Document Type and Number:
WIPO Patent Application WO/2016/165487
Kind Code:
A1
Abstract:
Provided are a bioprobe comprising AIE luminogens, and a method of imaging cells comprising introducing the bioprobe to a sample containing cells and imaging the cells by monitoring fluorescence emitted from the cell uptake of the bioprobe. Provided further is a method of monitoring a process of mitophagy comprising introducing the bioprobe to a sample containing cells, and monitoring the process of mitophagy by tracking morphological change.
Inventors:
TANG BEN ZHONG (CN)
ZHANG WEIJIE (CN)
KWOK TSZ KIN (CN)
ZHANG WEIJIE (CN)
KWOK TSZ KIN (CN)
Application Number:
PCT/CN2016/074337
Publication Date:
October 20, 2016
Filing Date:
February 23, 2016
Export Citation:
Assignee:
UNIV HONG KONG SCIENCE & TECH (CN)
International Classes:
C09K11/06; C07D213/38; C07F7/08
Foreign References:
| CN103865522A | 2014-06-18 | |||
| CN103842472A | 2014-06-04 | |||
| CN102706839A | 2012-10-03 | |||
| US20130210047A1 | 2013-08-15 |
Other References:
SHI HAIBIN ET AL.: "Fluorescent light-up probe with aggregation-induced emission characteristics for in vivo imaging of cell apoptosis", ORG. BIOMOL. CHEM., vol. 11, 10 September 2013 (2013-09-10), pages 7289 - 7296, XP055321236
Attorney, Agent or Firm:
TEE & HOWE INTELLECTUAL PROPERTY ATTORNEYS (10th Floor Tower D, Minsheng Financial Center, 28 Jianguomennei Avenue, Dongcheng District, Beijing 5, CN)
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