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Title:
IP¿3? RECEPTOR LIGANDS
Document Type and Number:
WIPO Patent Application WO/2000/075150
Kind Code:
A1
Abstract:
Compounds of general formula (I) or salts thereof, useful as ligands to inositol 1,4,5-trisphosphate (IP¿3?) receptor, wherein R is a group represented by general formula (A), (B) or (C) (wherein R?1¿ and R?2¿ are each independently C¿1-6? alkyl; R?3¿ is amino, mono(C¿1-6? alkyl)amino, di(C¿1-6? alkyl)amino, or C¿1-6? alkoxy; and X?-¿ is an anion); and n is an integer of 2 to 5.

Inventors:
Nagano, Tetsuo (1-28-15, Amanuma Suginami-ku, Tokyo, 167-0032, JP)
Kikuchi, Kazuya (1-5-1-315, Kosugaya Sakae-ku Yokohama-shi, Kanagawa, 247-0007, JP)
Inoue, Takanari (2-4-2, Kan-non Kawasaki-ku Kawasaki-shi, Kanagawa, 210-0831, JP)
Iino, Masamitsu (3-25-17-401, Tabata Kita-ku, Tokyo, 114-0014, JP)
Hirose, Kenzo (1-35-27-602, Hongo Bunkyo-ku, Tokyo, 113-0033, JP)
Application Number:
PCT/JP2000/003344
Publication Date:
December 14, 2000
Filing Date:
May 25, 2000
Export Citation:
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Assignee:
DAIICHI PHARMACEUTICAL CO., LTD. (14-10, Nihonbashi 3-chome Chuo-ku, Tokyo, 103-8234, JP)
Nagano, Tetsuo (1-28-15, Amanuma Suginami-ku, Tokyo, 167-0032, JP)
Kikuchi, Kazuya (1-5-1-315, Kosugaya Sakae-ku Yokohama-shi, Kanagawa, 247-0007, JP)
Inoue, Takanari (2-4-2, Kan-non Kawasaki-ku Kawasaki-shi, Kanagawa, 210-0831, JP)
Iino, Masamitsu (3-25-17-401, Tabata Kita-ku, Tokyo, 114-0014, JP)
Hirose, Kenzo (1-35-27-602, Hongo Bunkyo-ku, Tokyo, 113-0033, JP)
International Classes:
A61P43/00; C07F9/117; C07F9/655; C07F9/6561; (IPC1-7): C07F9/144; A61K31/661; A61K41/00; A61P43/00; C07D493/10; C07F9/655; C07F9/6561
Other References:
INOUE TAKANARI ET AL.: 'Synthesis and evaluation of 1-position-modified inositol 1,4,5-trisphosphate analogs' BIOORG. MED. CHEM. LETT. vol. 9, no. 12, 1999, pages 1697 - 1702, XP002931789
PRESTWICH GLENN D. ET AL.: 'Tethered IP3. Synthesis and biochemical applications of the 1-0-(3-aminopropyl) ester of inositol (1,4,5)-trisphosphate' J. AM. CHEM. SOC. vol. 113, no. 5, 1991, pages 1822 - 1825, XP002931790
See also references of EP 1188760A1
Attorney, Agent or Firm:
Imamura, Masazumi (5th Floor, KRF Bldg. 5-, Kyobashi 1-chome Chuo-ku Tokyo, 104-0031, JP)
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