Title:
RECOMBINANT BATROXOBIN MIXED COMPOSITION AND A HEMOSTATIC POWDER OR HEMOSTATIC PAD COMPRISING SAME
Document Type and Number:
WIPO Patent Application WO/2017/105094
Kind Code:
A1
Abstract:
The present invention relates to a novel recombinant batroxobin mixture, a hemostatic composition comprising the same, and a method for preparing the same. According to the present invention, the hemostatic composition of the present invention has an excellent hemostatic effect by suppressing rebleeding, and maintains activity thereof even when prepared in a solid form, and thus, the composition of the present invention can be easily used by being applied as a topical hemostatic agent.
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Inventors:
KIM JONG TAK (KR)
SEO MUN YOUNG (KR)
KIM JIN WOO (KR)
SEO MUN YOUNG (KR)
KIM JIN WOO (KR)
Application Number:
PCT/KR2016/014679
Publication Date:
June 22, 2017
Filing Date:
December 14, 2016
Export Citation:
Assignee:
NC BIT INC (KR)
International Classes:
C07K14/46; A61K9/70; A61K38/48; A61K47/36; A61K47/42; C08B37/00; C08B37/08
Foreign References:
| US7939067B2 | 2011-05-10 | |||
| US20150017225A1 | 2015-01-15 |
Other References:
LOCHNIT ET AL.: "Carbohydrate Structure Analysis of Batraxobin, a Thrombin-like Serine Protease from Bothrops Moojeni Venom", EUROPEAN JOURNAL OF BIOCHEMISTRY, vol. 228, 3 March 1995 (1995-03-03), pages 805 - 816, XP055393435
YOU ET AL.: "Functional Characterization of Recombinant Batroxobin, a Snake Venom Thrombin-like Enzyme, Expressed from Pichia Pastoris", FEBS LETTERS, vol. 571, 3 July 2004 (2004-07-03), pages 67 - 73, XP004523314
SOARES ET AL.: "Venom-sweet-venom: N-linked Glycosylation in Snake Venom Toxins", PROTEIN AND PEPTIDE LETTERS, vol. 16, 2009, pages 913 - 919
SARTIM ET AL.: "Snake Venom Galactoside-binding Lectins: A Structural and Functional Overview", JOURNAL OF VENOMOUS ANIMALS AND TOXINS INCLUDING TROPICAL DISEASES, vol. 21, no. 35, 24 September 2015 (2015-09-24), pages 1 - 11, XP055393437
YOU ET AL.: "Functional Characterization of Recombinant Batroxobin, a Snake Venom Thrombin-like Enzyme, Expressed from Pichia Pastoris", FEBS LETTERS, vol. 571, 3 July 2004 (2004-07-03), pages 67 - 73, XP004523314
SOARES ET AL.: "Venom-sweet-venom: N-linked Glycosylation in Snake Venom Toxins", PROTEIN AND PEPTIDE LETTERS, vol. 16, 2009, pages 913 - 919
SARTIM ET AL.: "Snake Venom Galactoside-binding Lectins: A Structural and Functional Overview", JOURNAL OF VENOMOUS ANIMALS AND TOXINS INCLUDING TROPICAL DISEASES, vol. 21, no. 35, 24 September 2015 (2015-09-24), pages 1 - 11, XP055393437
Attorney, Agent or Firm:
MUHANN PATENT & LAW (KR)
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