Title:
RECOMBINANT CANINE PD-1 FUSION PROTEIN AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/051661
Kind Code:
A1
Abstract:
A recombinant canine PD-1 fusion protein and a preparation method therefor and an application thereof. The fusion protein is formed by directly or indirectly linking the extracellular domain of a canine PD-1 protein or the mutant of the extracellular domain of the canine PD-1 protein to an Fc fragment. Compared with wild-type PD-1, the recombinant canine PD-1 fusion protein has higher affinity and a better effect, and provides more options for the immunotherapy of canine tumors.
Inventors:
LUO HAOSHU (CN)
ZHU LINA (CN)
SHI LEI (CN)
YU JINKU (CN)
HAN GUO (CN)
XIONG JIANSHENG (CN)
ZHU LINA (CN)
SHI LEI (CN)
YU JINKU (CN)
HAN GUO (CN)
XIONG JIANSHENG (CN)
Application Number:
PCT/CN2019/122524
Publication Date:
March 25, 2021
Filing Date:
December 03, 2019
Export Citation:
Assignee:
BEIJING VJT BIO CO LTD (CN)
International Classes:
C07K19/00; A61K38/17; A61P35/00; C07K14/705; C12N15/62; C12N15/85
Domestic Patent References:
| WO2018077189A1 | 2018-05-03 | |||
| WO2016050721A1 | 2016-04-07 |
Foreign References:
| CN109867725A | 2019-06-11 | |||
| CN108752460A | 2018-11-06 | |||
| CN107987153A | 2018-05-04 | |||
| US20120121634A1 | 2012-05-17 | |||
| US20160333096A1 | 2016-11-17 |
Other References:
NAOYA MAEKAWA, SATORU KONNAI, RYOYO IKEBUCHI, TOMOHIRO OKAGAWA, MAMI ADACHI, SATOSHI TAKAGI, YUMIKO KAGAWA, CHIE NAKAJIMA, YASUHIK: "Expression of PD-L1 on Canine Tumor Cells and Enhancement of IFN-γ Production from Tumor-Infiltrating Cells by PD-L1 Blockade", PLOS ONE, vol. 9, no. 6, pages e98415, XP055179324, DOI: 10.1371/journal.pone.0098415
NAOYA MAEKAWA, SATORU KONNAI, SATOSHI TAKAGI, YUMIKO KAGAWA, TOMOHIRO OKAGAWA, ASAMI NISHIMORI, RYOYO IKEBUCHI, YUSUKE IZUMI, TATS: "A canine chimeric monoclonal antibody targeting PD-L1 and its clinical efficacy in canine oral malignant melanoma or undifferentiated sarcoma", SCIENTIFIC REPORTS, vol. 7, no. 1, 1 December 2017 (2017-12-01), XP055664323, DOI: 10.1038/s41598-017-09444-2
DUAN WENYUAN, YUN BAI, ZHANG HUA-XIN, MAN JIANG, LI WAN-LING: "Construction of human PD-1-Fc chimeric molecule and its expression and identification in mammalian CHO cell", IMMUNOLOGICAL JOURNAL, vol. 21, no. 6, 1 November 2005 (2005-11-01), pages 460 - 467, XP055792374, DOI: 10.13431/j.cnki.immunol.j.20050135
NAOYA MAEKAWA, SATORU KONNAI, SATOSHI TAKAGI, YUMIKO KAGAWA, TOMOHIRO OKAGAWA, ASAMI NISHIMORI, RYOYO IKEBUCHI, YUSUKE IZUMI, TATS: "A canine chimeric monoclonal antibody targeting PD-L1 and its clinical efficacy in canine oral malignant melanoma or undifferentiated sarcoma", SCIENTIFIC REPORTS, vol. 7, no. 1, 1 December 2017 (2017-12-01), XP055664323, DOI: 10.1038/s41598-017-09444-2
DUAN WENYUAN, YUN BAI, ZHANG HUA-XIN, MAN JIANG, LI WAN-LING: "Construction of human PD-1-Fc chimeric molecule and its expression and identification in mammalian CHO cell", IMMUNOLOGICAL JOURNAL, vol. 21, no. 6, 1 November 2005 (2005-11-01), pages 460 - 467, XP055792374, DOI: 10.13431/j.cnki.immunol.j.20050135
Attorney, Agent or Firm:
CN-KNOWHOW INTELLECTUAL PROPERTY AGENT LIMITED (CN)
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