Title:
RECOMBINANT CHIMERIC ANTIGEN RECEPTOR GENE AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/157691
Kind Code:
A1
Abstract:
The present invention provides a recombinant chimeric antigen receptor (CAR) gene, a vector comprising same, a CAR-T cell and use thereof. The recombinant CAR gene comprises a nucleic acid sequence encoding the following portions: an antigen-binding portion, a transmembrane portion, and a CD137 cytoplasm functional region and a CD3zeta cytoplasm functional region linked in any order, of CD30 antibody. Further provided is a method for treating Hodgkin's lymphoma or anaplastic large cell lymphoma or other CD30 positive tumors using the CAR-T cell of the invention.
Inventors:
SUN XIULIAN (CN)
Application Number:
PCT/CN2018/076801
Publication Date:
August 22, 2019
Filing Date:
February 14, 2018
Export Citation:
Assignee:
YIMING CELL BIOTECH LTD (CN)
International Classes:
C12N15/62; A61K35/17; A61P35/00; C07K19/00; C12N5/10; C12N15/86
Foreign References:
| CN105924527A | 2016-09-07 | |||
| CN105859890A | 2016-08-17 | |||
| CN107312097A | 2017-11-03 |
Attorney, Agent or Firm:
NTD UNIVATION INTELLECTUAL PROPERTY AGENCY LTD. (CN)
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