Title:
RECOMBINANT GROUP 2 ALLERGEN PROTEIN FROM DERMATOPHAGOIDES PTERONYSSINUS, AND PREPARATION METHOD AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/121633
Kind Code:
A1
Abstract:
Provided are a recombinant group 2 allergen protein from Dermatophagoides pteronyssinus, and an encoding gene and preparation method thereof. The encoding gene is obtained by preforming codon optimization on a wild-type encoding gene of a group 2 allergen protein from Dermatophagoides pteronyssinus and is beneficial to expression in Pichia pastoris. Further, an acting element increasing target protein expression is added to the expression system.
Inventors:
MA BRUCE YONG (CN)
FAN YU (CN)
WANG ANLIANG (CN)
WANG JUN (CN)
FAN YU (CN)
WANG ANLIANG (CN)
WANG JUN (CN)
Application Number:
PCT/CN2017/119173
Publication Date:
July 05, 2018
Filing Date:
December 28, 2017
Export Citation:
Assignee:
ZONHON BIOPHARMA INST INC (CN)
GENSUN INST BIOMEDICINE CO LTD (CN)
GENSUN INST BIOMEDICINE CO LTD (CN)
International Classes:
C12N15/12; A61K39/35; A61P37/08; C07K14/435; C12N1/19; C12N15/81; C12R1/84
Foreign References:
| CN105307679A | 2016-02-03 | |||
| CN1385528A | 2002-12-18 | |||
| US20110293665A1 | 2011-12-01 | |||
| CN102732541A | 2012-10-17 |
Other References:
DATABASE GenBank 7 January 2008 (2008-01-07), CUI, Y. -B. ET AL.: "Dermatophagoides pteronyssinus Der p 2 allergen mRNA, complete cds", Database accession no. EU346693.1
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