Title:
RECOMBINANT HIV-1 SUBCLASS D ENVELOPE GLYCOPROTEINS
Document Type and Number:
WIPO Patent Application WO2004046168
Kind Code:
A3
Abstract:
The present invention relates to recombinant nucleic acid molecules encoding recombinant HIV-1 subclass D envelope gp140 glycoproteins and to the glycoproteins encoded by same. The invention also relates to vectors comprising the nucleic acid molecules and vaccine compositions comprising the nucleic acid molecules or the glycoproteins. The invention discloses a method for inducing a broad immunogenic response to HIV-1 for the neutralization of HIV-1 virus.
Inventors:
VANCOTT THOMAS C (US)
HARRIS MATHEW E (US)
KALYANARAMAN VANIAMBADI S (US)
HARRIS MATHEW E (US)
KALYANARAMAN VANIAMBADI S (US)
Application Number:
PCT/US2003/036653
Publication Date:
April 14, 2005
Filing Date:
November 17, 2003
Export Citation:
Assignee:
HENRY M JACKSON FOUNDATION (US)
VANCOTT THOMAS C (US)
HARRIS MATHEW E (US)
KALYANARAMAN VANIAMBADI S (US)
VANCOTT THOMAS C (US)
HARRIS MATHEW E (US)
KALYANARAMAN VANIAMBADI S (US)
International Classes:
C07H21/04; C07K14/16; C12N15/00; A61K39/00; C07K; (IPC1-7): A61K39/00; C07H21/04; C12N15/00
Domestic Patent References:
| WO1994028929A1 | 1994-12-22 | |||
| WO2001060836A1 | 2001-08-23 | |||
| WO2000039302A2 | 2000-07-06 |
Foreign References:
| US5864027A | 1999-01-26 | |||
| US5696238A | 1997-12-09 |
Other References:
BIKANDOU B. ET AL.: "Genetic subtypes of HIV type 1 in Republic of Congo", AIDS RESEARCH AND HUMAN RETROVIRUSES, vol. 16, no. 7, 1 May 2000 (2000-05-01), pages 613 - 619, XP002985424
ROBBINS K.E. ET AL.: "Genetic analysis of human immunodeficiency virus type 1 strains in Kenya: a comparison using phylogenetic analysis and a combinatorial melting assay", AIDS RESEARCH AND HUMAN RETROVIRUSES, vol. 15, no. 4, 1 March 1999 (1999-03-01), pages 329 - 335, XP002985425
ROBBINS K.E. ET AL.: "Genetic analysis of human immunodeficiency virus type 1 strains in Kenya: a comparison using phylogenetic analysis and a combinatorial melting assay", AIDS RESEARCH AND HUMAN RETROVIRUSES, vol. 15, no. 4, 1 March 1999 (1999-03-01), pages 329 - 335, XP002985425
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