RECOMBINANT HOST CELLS WITH IMPROVED PRODUCTION OF TETRAKETIDE DERIVATIVES

Title:

RECOMBINANT HOST CELLS WITH IMPROVED PRODUCTION OF TETRAKETIDE DERIVATIVES

Document Type and Number:

WIPO Patent Application WO/2020/141230

Kind Code:

A8

Abstract:

The present invention relates to arecombinant microbial host cell producing a tetraketide or derivatives thereof from one or more substrates selected from cinnamoyl-CoA, p-Coumaroyl-CoA, Caffeoyl-CoA, Feruloyl-CoA, malonyl-CoA, sinapoyl-CoA and dihydro derivatives thereof, comprising an operative biosynthetic metabolic pathway for the tetraketide or derivatives thereof comprising a chalcone isomerase-like (CHIL) polypeptide heterologous to the host cell and a Type 3 polyketide synthase (PKS).

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Inventors:

NAESBY MICHAEL (FR)

Application Number:

PCT/EP2020/050150

Publication Date:

June 17, 2021

Filing Date:

January 06, 2020

Export Citation:

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Assignee:

BARRIT SARL (FR)
IPTECTOR ASSETS APS (DK)

International Classes:

C12N1/21; A61K31/7048; C07K14/415; C12N9/10; C12N9/90; C12N15/29; C12N15/52; C12P17/06

Attorney, Agent or Firm:

BIRKELAND, Morten (DK)

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