Title:
RECOMBINANT HUMAN HNP-1 PROTEIN HAVING BIOLOGICAL ACTIVITY AND APPLICATION
Document Type and Number:
WIPO Patent Application WO/2019/210845
Kind Code:
A1
Abstract:
A recombinant human HNP-1 protein. By constructing and using Escherichia coli expression system, a mature human HNP-1 protein having biological activity is prepared. The recombinant human HNP-1 protein has antibacterial activity, i.e., the HNP-1 protein having activity is expressed by using a prokaryotic system.
Inventors:
XU PING (CN)
XIE QI (CN)
WU JUNZHU (CN)
WANG YIN (CN)
WEI WEI (CN)
XIAO WEIDI (CN)
WANG YIHAO (CN)
CHANG LEI (CN)
GAO HUIYING (CN)
LIU YANHONG (CN)
XIE QI (CN)
WU JUNZHU (CN)
WANG YIN (CN)
WEI WEI (CN)
XIAO WEIDI (CN)
WANG YIHAO (CN)
CHANG LEI (CN)
GAO HUIYING (CN)
LIU YANHONG (CN)
Application Number:
PCT/CN2019/085130
Publication Date:
November 07, 2019
Filing Date:
April 30, 2019
Export Citation:
Assignee:
SOURCE & SPECTRUM PEAK SCIENT BEIJING CHINA (CN)
International Classes:
C12N1/21; C12N15/12; C12N15/70
Foreign References:
| CN1810954A | 2006-08-02 | |||
| CN1904036A | 2007-01-31 |
Other References:
ZHANG, MANCHAO ET AL.: "Expression of Human Defesin-I (HNP-I) in E.coli", CHINESE BIOCHEMICAL JOURNAL, vol. 13, no. 3, 30 June 1997 (1997-06-30), pages 264 - 268
FIGUEREDO, S. ET AL.: "Expression and Purification of Recombinant a-Defensins and alpha- Defensin Precursors in Escherichia Coli", ANTIMICROBIAL PEPTIDES, vol. 6, no. 18, 31 December 2009 (2009-12-31) - 2010, pages 47 - 60
XU, WEI ET AL.: "HNP-1 (Construction and Soluble Expression of Fusion Vector of Human Neutrophil Peptide 1 (HNP-1", JOURNAL OF ZHEJIANG UNIVERSITY OF TECHNOLOGY, vol. 36, no. 3, 30 June 2008 (2008-06-30), pages 272 - 275; 284
PAZGIER, M. ET AL.: "Expression and Purification of Recombinant Human alpha-Defensins in Escherichia Coli", PROTEIN EXPRESSION AND PURIFICATION, vol. 49, no. 1, 20 May 2006 (2006-05-20) - September 2006 (2006-09-01), pages 1 - 8, XP024908893
FIGUEREDO, S. ET AL.: "Expression and Purification of Recombinant a-Defensins and alpha- Defensin Precursors in Escherichia Coli", ANTIMICROBIAL PEPTIDES, vol. 6, no. 18, 31 December 2009 (2009-12-31) - 2010, pages 47 - 60
XU, WEI ET AL.: "HNP-1 (Construction and Soluble Expression of Fusion Vector of Human Neutrophil Peptide 1 (HNP-1", JOURNAL OF ZHEJIANG UNIVERSITY OF TECHNOLOGY, vol. 36, no. 3, 30 June 2008 (2008-06-30), pages 272 - 275; 284
PAZGIER, M. ET AL.: "Expression and Purification of Recombinant Human alpha-Defensins in Escherichia Coli", PROTEIN EXPRESSION AND PURIFICATION, vol. 49, no. 1, 20 May 2006 (2006-05-20) - September 2006 (2006-09-01), pages 1 - 8, XP024908893
Attorney, Agent or Firm:
LECOME INTELLECTUAL PROPERTY AGENT LTD. (CN)
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