Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
RECOMBINANT LACTIC ACID BACTERIA AND THE USE THEREOF IN ORAL UNIVERSAL INFLUENZA VACCINE
Document Type and Number:
WIPO Patent Application WO/2017/084635
Kind Code:
A1
Abstract:
The present invention relates to an oral universal influenza vaccine comprising recombinant lactic acid bacteria which express proteins including but not limited to ferritin protein plus highly-conserved stem fragment of hemagglutinin (HA) proteins expressed in all known influenza viruses. The present invention also relates to the recombinant protein comprising the highly-conserved stem fragment of HA and ferritin proteins.

Inventors:
SHUM, Chung Yan (Room 2209, Tsui Mui House Tsui Ping Estate,Kwun Tong, Hong Kong, Kong, CN)
WONG, Tak Keung Andy (House 68, Seasons Monarch 183 Kam Tin Road,Yuen Long, N.T, Hong Kong, Kong, CN)
Application Number:
CN2016/106690
Publication Date:
May 26, 2017
Filing Date:
November 21, 2016
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
CREATION PLUS BIOTECHNOLOGY CO. LTD. (Room 7, 7/F Block B1, Hang Wai Industrial Centre, 6 Kin Tai Street, Tuen Mun, N.T, Hong Kong, Kong, CN)
International Classes:
C12N15/44; A61K39/145; C12N1/21
Other References:
LEI, H. ET AL.: "Cross-protection of Lactococcus lactis-displayed HA2 subunit against homologous and heterologous influenza a viruses in mice.", ARCH VIROL., vol. 160, 11 September 2015 (2015-09-11), pages 3011 - 3019, XP035888457
YASSINE, H. M. ET AL.: "Hemagglutinin-stem nanoparticles generate heterosubtypic influenza protection.", NATURE MEDICINE., vol. 21, no. 9, 24 August 2015 (2015-08-24), pages 1065 - 1070, XP002755796
INOUE, Y. ET AL.: "Induction of Anti-influenza Immunity by Modified Green Fluorescent Protein (GFP) Carrying Hemagglutinin-derived Epitope Structure.", THE JOURNAL OF BIOLOGICAL CHEMISTRY ., vol. 288, no. 7, 15 February 2013 (2013-02-15), pages 4985 - 4990, XP055384097
WANG, Z. ET AL.: "Oral immunization with recombinant Lactococcus lactis expressing the hemagglutinin of the avian influenza virus induces mucosal and systemic immune responses.", FUTURE MICROBIOL., vol. 7, no. 8, 15 February 2013 (2013-02-15), pages 1003 - 1010
MALLAJOSYULA, V. V. A. ET AL.: "Hemagglutinin sequence conservation guided stem immunogen design from influenza A H3 subtype.", FRONT IMMUNOL., vol. 6, 26 June 2013 (2013-06-26), pages 1 - 12
KANEKIYO, M. ET AL.: "Self-assembling influenza nanoparticle vaccines elicit broadly neutralizing H1N1 antibodies.", NATURE, vol. 499, 4 July 2013 (2013-07-04), pages 102 - 106, XP002735539, DOI: doi:10.1038/nature12202
STEEL, J. ET AL.: "Influenza virus vaccine based on the conserved hemagglutinin stalk Domain.", MBIO., vol. 1, no. 1, 18 May 2010 (2010-05-18), pages 1 - 9, XP002676044
Attorney, Agent or Firm:
CHINA PAT INTELLECTUAL PROPERTY OFFICE (2nd Floor, Zhongguancun Intellectual Property Building Block B,No.21 Haidian South Road, Beijing 0, 100080, CN)
Download PDF: