Title:
RECOMBINANT MEASLES VIRUSES EXPRESSING EPITOPES PF ANTIGENS OF RNA VIRUSES AND USE OF THE RECOMBINANT VIRUSES FOR THE PREPARATION OF VACCINE COMPOSITIONS
Document Type and Number:
WIPO Patent Application WO2004001051
Kind Code:
A3
Abstract:
The invention relates to a recombinant measles virus expressing a heterologous amino acid sequence derived from an antigen of a determined RNA virus, said recombinant measles virus being capable of eliciting a humoral and/or cellular immune response against measles virus or against said RNA virus or against both measles virus and against said RNA virus. It also relates to the use of said recombinant measles virus for the preparation of immunogenic composition.
Inventors:
TANGY FREDERIC (FR)
LORIN CLARISSE (FR)
MOLLET LUCILE (FR)
DELEBECQUE FREDERIC (FR)
LORIN CLARISSE (FR)
MOLLET LUCILE (FR)
DELEBECQUE FREDERIC (FR)
Application Number:
PCT/EP2003/007146
Publication Date:
May 27, 2004
Filing Date:
June 20, 2003
Export Citation:
Assignee:
PASTEUR INSTITUT (FR)
CENTRE NAT RECH SCIENT (FR)
TANGY FREDERIC (FR)
LORIN CLARISSE (FR)
MOLLET LUCILE (FR)
DELEBECQUE FREDERIC (FR)
CENTRE NAT RECH SCIENT (FR)
TANGY FREDERIC (FR)
LORIN CLARISSE (FR)
MOLLET LUCILE (FR)
DELEBECQUE FREDERIC (FR)
International Classes:
A61K47/48; C07K14/12; C07K14/16; C07K14/18; C12N7/00; C12N15/86; (IPC1-7): C12N15/86; C12N7/00
Domestic Patent References:
| WO1997006270A1 | 1997-02-20 | |||
| WO1998037911A1 | 1998-09-03 |
Foreign References:
| EP0440219A1 | 1991-08-07 |
Other References:
WANG Z ET AL: "Recombinant measles viruses expressing heterologous antigens of mumps and simian immunodeficiency viruses", VACCINE, BUTTERWORTH SCIENTIFIC. GUILDFORD, GB, vol. 19, no. 17-19, 21 March 2001 (2001-03-21), pages 2329 - 2336, XP004231045, ISSN: 0264-410X
TANGY ET AL.: "Measles vaccine as a potential vector for aids vaccination", AIDS VACCINE CONFERENCE, XX, XX, 5 September 2001 (2001-09-05) - 8 September 2001 (2001-09-08), XX, XP002230316
SINGH M ET AL: "A recombinant measles virus expressing hepatitis B virus surface antigen induces humoral immune responses in genetically modified mice.", JOURNAL OF VIROLOGY, vol. 73, no. 6, June 1999 (1999-06-01), pages 4823 - 4828, XP002230315, ISSN: 0022-538X
MUSTER T ET AL: "A conserved neutralizing epitope on gp41 of human immunodeficiency virus type 1", JOURNAL OF VIROLOGY, NEW YORK, US, US, vol. 67, no. 11, 1 November 1993 (1993-11-01), pages 6642 - 6647, XP000613016, ISSN: 0022-538X
SANDERS R W ET AL: "Variable-loop-deleted variants of the Human Immunodeficiency Virus Type 1 envelope glycoprotein can be stabilized by an intermolecular disulfide bond between the gp120 and gp41 subunits", JOURNAL OF VIROLOGY, THE AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 74, no. 11, June 2000 (2000-06-01), pages 5091 - 5100, XP002210876, ISSN: 0022-538X
COLOMBAGE G ET AL: "DNA-based and alphavirus-vectored immunisation with prM and E proteins elicits long-lived and protective immunity against the flavivirus, Murray Valley encephalitis virus", VIROLOGY, ACADEMIC PRESS,ORLANDO, US, vol. 250, 1998, pages 151 - 163, XP004445627, ISSN: 0042-6822
DAVIS B S ET AL: "West Nile virus recombinant DNA vaccine protects mouse and horse from virus challenge and expresses in vitro a noninfectious recombinant antigen that can be used in enzyme-linked immunosorbent assays.", JOURNAL OF VIROLOGY, vol. 75, no. 9, May 2001 (2001-05-01), pages 4040 - 4047, XP002239873, ISSN: 0022-538X
WANG T ET AL: "Immunization of mice against West Nile virus with recombinant envelope protein.", JOURNAL OF IMMUNOLOGY (BALTIMORE, MD.: 1950) UNITED STATES 1 NOV 2001, vol. 167, no. 9, 1 November 2001 (2001-11-01), pages 5273 - 5277, XP002961138, ISSN: 0022-1767
ARROYO J ET AL: "Yellow fever vector live-virus vaccines: West Nile virus vaccine development.", TRENDS IN MOLECULAR MEDICINE, vol. 7, no. 8, August 2001 (2001-08-01), pages 350 - 354, XP002239874, ISSN: 1471-4914
SPIELHOFER PIUS ET AL: "Chimeric measles viruses with a foreign envelope", JOURNAL OF VIROLOGY, vol. 72, no. 3, March 1998 (1998-03-01), pages 2150 - 2159, XP002268131, ISSN: 0022-538X
SCHLERETH BERND ET AL: "Successful vaccine-induced seroconversion by single-dose immunization in the presence of measles virus-specific maternal antibodies", JOURNAL OF VIROLOGY, vol. 74, no. 10, May 2000 (2000-05-01), pages 4652 - 4657, XP002268132, ISSN: 0022-538X
TANGY ET AL.: "Measles vaccine as a potential vector for aids vaccination", AIDS VACCINE CONFERENCE, XX, XX, 5 September 2001 (2001-09-05) - 8 September 2001 (2001-09-08), XX, XP002230316
SINGH M ET AL: "A recombinant measles virus expressing hepatitis B virus surface antigen induces humoral immune responses in genetically modified mice.", JOURNAL OF VIROLOGY, vol. 73, no. 6, June 1999 (1999-06-01), pages 4823 - 4828, XP002230315, ISSN: 0022-538X
MUSTER T ET AL: "A conserved neutralizing epitope on gp41 of human immunodeficiency virus type 1", JOURNAL OF VIROLOGY, NEW YORK, US, US, vol. 67, no. 11, 1 November 1993 (1993-11-01), pages 6642 - 6647, XP000613016, ISSN: 0022-538X
SANDERS R W ET AL: "Variable-loop-deleted variants of the Human Immunodeficiency Virus Type 1 envelope glycoprotein can be stabilized by an intermolecular disulfide bond between the gp120 and gp41 subunits", JOURNAL OF VIROLOGY, THE AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 74, no. 11, June 2000 (2000-06-01), pages 5091 - 5100, XP002210876, ISSN: 0022-538X
COLOMBAGE G ET AL: "DNA-based and alphavirus-vectored immunisation with prM and E proteins elicits long-lived and protective immunity against the flavivirus, Murray Valley encephalitis virus", VIROLOGY, ACADEMIC PRESS,ORLANDO, US, vol. 250, 1998, pages 151 - 163, XP004445627, ISSN: 0042-6822
DAVIS B S ET AL: "West Nile virus recombinant DNA vaccine protects mouse and horse from virus challenge and expresses in vitro a noninfectious recombinant antigen that can be used in enzyme-linked immunosorbent assays.", JOURNAL OF VIROLOGY, vol. 75, no. 9, May 2001 (2001-05-01), pages 4040 - 4047, XP002239873, ISSN: 0022-538X
WANG T ET AL: "Immunization of mice against West Nile virus with recombinant envelope protein.", JOURNAL OF IMMUNOLOGY (BALTIMORE, MD.: 1950) UNITED STATES 1 NOV 2001, vol. 167, no. 9, 1 November 2001 (2001-11-01), pages 5273 - 5277, XP002961138, ISSN: 0022-1767
ARROYO J ET AL: "Yellow fever vector live-virus vaccines: West Nile virus vaccine development.", TRENDS IN MOLECULAR MEDICINE, vol. 7, no. 8, August 2001 (2001-08-01), pages 350 - 354, XP002239874, ISSN: 1471-4914
SPIELHOFER PIUS ET AL: "Chimeric measles viruses with a foreign envelope", JOURNAL OF VIROLOGY, vol. 72, no. 3, March 1998 (1998-03-01), pages 2150 - 2159, XP002268131, ISSN: 0022-538X
SCHLERETH BERND ET AL: "Successful vaccine-induced seroconversion by single-dose immunization in the presence of measles virus-specific maternal antibodies", JOURNAL OF VIROLOGY, vol. 74, no. 10, May 2000 (2000-05-01), pages 4652 - 4657, XP002268132, ISSN: 0022-538X
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