Title:
RECOMBINANT MICROORGANISM FOR PRODUCING CYTIDINE DIPHOSPHATE AND METHOD FOR PRODUCING CYTIDINE DIPHOSPHATE
Document Type and Number:
WIPO Patent Application WO/2019/007055
Kind Code:
A1
Abstract:
Provided are a recombinant microorganism for producing cytidine diphosphate and a method for producing cytidine diphosphate using the recombinant microorganism.
Inventors:
JIANG JUNJUN (CN)
FAN JUNYIN (CN)
TIAN FENG (CN)
WANG XINTONG (CN)
ZHANG KAILIN (CN)
HU ZHIHAO (US)
FAN JUNYIN (CN)
TIAN FENG (CN)
WANG XINTONG (CN)
ZHANG KAILIN (CN)
HU ZHIHAO (US)
Application Number:
PCT/CN2018/075238
Publication Date:
January 10, 2019
Filing Date:
February 05, 2018
Export Citation:
Assignee:
SUZHOU BIOSYNTHETICA CO LTD (CN)
International Classes:
C12N1/21; C12P19/30; C12R1/19
Domestic Patent References:
| WO2017073701A2 | 2017-05-04 | |||
| WO2005030974A1 | 2005-04-07 |
Foreign References:
| CN102605025A | 2012-07-25 | |||
| CN104774799A | 2015-07-15 | |||
| CN105463042A | 2016-04-06 | |||
| US20130029395A1 | 2013-01-31 | |||
| CN102605025A | 2012-07-25 | |||
| CN104774799A | 2015-07-15 | |||
| JP5112869B2 | 2013-01-09 | |||
| CN106754602A | 2017-05-31 |
Other References:
YINGMIAO: "Efficient multi-enzyme-catalyzed CDP-choline production driven by an ATP donor module", APPL MICROBIOL BIOTECHNOL, vol. 101, no. 4, 13 October 2016 (2016-10-13), pages 1409 - 1417, XP036137870, ISSN: 1432-0614, Retrieved from the Internet
SHOJI SHIROTA, AGR BIOL CHEN, vol. 35, no. 3, 1975, pages 1469 - 1474
TAKATA J, FERMEM TECHNOL, vol. 60, no. 5, 1982, pages 431 - 437
QIU WEIRAN, CHINESE JOURNAL OF BIOCHEMICAL PHARMACEUTICS, vol. 62, no. 4, 1992, pages 37 - 39
YU DONGSHENG, JOURNAL OF WUXI UNIVERSITY OF LIGHT INDUSTRY, vol. 21, no. 3, 2002, pages 277 - 280
YING HANJIE: "GENETICALLY ENGINEERED BACTERIUM STRAIN EXPRESSING CHOLINE KINASE AND PHOSPHOCHOLINE CYTIDYLYLTRANSFERASE AND CONSTRUCTION", METHOD AND APPLICATION THEREOF, 2015
TSUKAGOSHI Y, J BACTERIOL., vol. 173, no. 6, 1991, pages 2134 - 6
CARTER, J LIPID RES, vol. 7, no. 5, 1966, pages 678 - 83
VISEDO GONZALEZ, BIOCHEM J, vol. 260, no. 1, 1989, pages 299 - 301
ROHDICH, PROC NATL ACAD SCI USA, vol. 96, no. 21, 1999, pages 11758 - 63
NEUMANN, J BIOL CHEM, vol. 284, no. 33, 2009, pages 21891 - 8
GHALAMBOR, J BIOL CHEM 1966, vol. 241, no. 13, 1966, pages 3216 - 21
SHI, EMBO J, vol. 17, no. 11, 1998, pages 3197 - 206
DENAPAITE D, PLOS ONE, vol. 5, no. 2, 2010, pages e9426
CHANG, MPLOS ONE, vol. 11, no. 10, 2016, pages e165006
GADDA, APPL ENVIRON MICROBIOL, vol. 69, no. 4, 2003, pages 2126 - 32
LORD, BIOCHIM BIOPHYS ACTA, vol. 267, no. 2, 1972, pages 227 - 37
SUNG, BIOCHEM. J., vol. 105, 1967, pages 497
IYENGAR A, BIOCHEM J., vol. 369, 2003, pages 497 - 507
DEVROEDE N, J BACTERIOL., vol. 188, no. 9, 2006, pages 3236 - 45
KIM, MICROB CELL FACT, vol. 14, 2015, pages 98
DELANNAY S, J MOL BIOL., vol. 286, no. 4, 1999, pages 1217 - 28
COUDRAY L, BIOORG MED CHEM., vol. 17, no. 22, 2009, pages 7680 - 9
KAJ FRANK JENSEN, JOURNAL OF BACTERIOLOGY, 1993, pages 3401 - 3407
J. BROSIUSM. ERFLE: "J. Storella Spacing of the -10 and -35 regions in the tac promoter Effect on its in vivo activity", J. BIOL. CHEM., vol. 260, 1985, pages 3539 - 3541, XP002674569
WALZ, A.PIRROTTA, V.: "Sequence of the PR promoter of phage X", NATURE, vol. 254, 1975, pages 118 - 121
SHIMAOKA, J BIOSCI BIOENG, vol. 103, no. 3, 2007, pages 255 - 61
MEYER P, J BIOL CHEM., vol. 283, no. 51, 2008, pages 36011 - 8
DATSENKO KA, PROC NATL ACAD SCI USA, vol. 97, no. 12, 2000, pages 6640 - 6664
BABA T., MOL SYST BIOL, vol. 2, no. 1, 2006, pages 0008
J. SAMBROOK, MOLECULAR CLONING: A LABORATORY MANUAL, 2002, pages 1595
LIU YINGMIAO; WANG JUNZHI; XU CHONGMAO; CHEN YONG; YANG JUNJIE; LIU DONG; NIU HUANQING; JIANG YU; YANG SHENG; YING HANJIE: "Efficient multi-enzyme-catalyzed CDP-choline production driven by an ATP donor module", APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, vol. 101, no. 4, 13 October 2016 (2016-10-13), Berlin/Heidelberg, pages 1409 - 1417, XP036137870, ISSN: 0175-7598, DOI: 10.1007/s00253-016-7874-0
ALVES-PEREIRA ISABEL, CANALES JOSÉ, CABEZAS ALICIA, MARTÍN CORDERO PALOMA, COSTAS MARÍA JESÚS, CAMESELLE JOSÉ CARLOS: "CDP-Alcohol Hydrolase, a Very Efficient Activity of the 5′-Nucleotidase/UDP-Sugar Hydrolase Encoded by the ushA Gene of Yersinia intermedia and Escherichia coli", JOURNAL OF BACTERIOLOGY, vol. 190, no. 18, 15 September 2008 (2008-09-15), US , pages 6153 - 6161, XP055858774, ISSN: 0021-9193, DOI: 10.1128/JB.00658-08
BULAWA CHRISTINE E, HERMES JEFFREY D, RAETZ CHRISTIAN R H: "Chloroform-soluble Nucleotides in Escherichia coli - ROLE OF CDP-DIGLYCERIDE IN THE ENZYMATIC CYTIDYLYLATION OF PHOSPHOMONOESTER ACCEPTORS", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 258, no. 24, 1 December 1983 (1983-12-01), pages 14974 - 14980, XP055858800
IMPERIAL SANTIAGO, CENTELLES JOSEP J.: "Enzyme Kinetic Equations of Irreversible and Reversible Reactions in Metabolism", JOURNAL OF BIOSCIENCES AND MEDICINES, vol. 02, no. 04, 1 January 2014 (2014-01-01), pages 24 - 29, XP055858819, ISSN: 2327-5081, DOI: 10.4236/jbm.2014.24005
ANDRESEN PER A, KAASEN INGA, STYRVOLD OLAF B, BOULNOIS GRAHAM, STROM ARNE R: "Molecular Cloning, Physical Mapping and Expression of the bet Genes Governing the Osmoregulatory Choline-Glycine Betaine Pathway of Escherichia coli", JOURNAL OF GENERAL MICROBIOLOGY, vol. 134, 1 January 1988 (1988-01-01), pages 1737 - 1746, XP055858825
INOUYE H, MICHAELIS S, WRIGHT A, BECKWITH J: "Cloning and restriction mapping of the alkaline phosphatase structural gene (phoA) of Escherichia coli and generation of deletion mutants in vitro", JOURNAL OF BACTERIOLOGY, vol. 146, no. 2, 1 May 1981 (1981-05-01), US , pages 668 - 675, XP055858832, ISSN: 0021-9193, DOI: 10.1128/jb.146.2.668-675.1981
AMINI, N., MCKELVIE, I.: "An enzymatic flow analysis method for the determination of phosphatidylcholine in sediment pore waters and extracts", TALANTA, vol. 66, no. 2, 15 April 2005 (2005-04-15), NL , pages 445 - 452, XP004872767, ISSN: 0039-9140, DOI: 10.1016/j.talanta.2004.11.001
FORLEO C., M. BENVENUTI, V. CALDERONE, S. SCHIPPA, J.-D. DOCQUIER, M. C. THALLER, G. M. ROSSOLINI AND S. MANGANI: "Expression, purification, crystallization and preliminary X-ray characterization of the class B acid phosphatase (AphA) from Escherichia coli", ACTA CRYSTALLOGRAPHICA, vol. D59, 1 January 2003 (2003-01-01), pages 1058 - 1060, XP055858853, ISSN: 0907-4449, DOI: 10.1107/S0907444903006826
DOMENECH CARLOS E, LISA TERESITA A, SALVANO MARIO A, GARRIDO MÓNICA N: "Pseudomonas aeruginosa acid phosphatase - Activation by divalent cations and inhibition by aluminium ion", FEBS LETTERS, vol. 299, no. 1, 1 March 1992 (1992-03-01), NL , pages 96 - 98, XP055858859, ISSN: 0014-5793, DOI: 10.1016/0014-5793(92)80108-S
KIM K ET AL: "Isolation and characterization of the Saccharomyces cerevisiae EKI1 gene encoding ethanolamine kinase.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 274, no. 21, 21 May 1999 (1999-05-21), US , pages 14857 - 14866, XP002219583, ISSN: 0021-9258, DOI: 10.1074/jbc.274.21.14857
ROCK CHARLES O., HEATH RICHARD J., PARK HEE-WON, JACKOWSKI SUZANNE: "The licC Gene of Streptococcus pneumoniae Encodes a CTP:Phosphocholine Cytidylyltransferase", JOURNAL OF BACTERIOLOGY, vol. 183, no. 16, 15 August 2001 (2001-08-15), US , pages 4927 - 4931, XP055858868, ISSN: 0021-9193, DOI: 10.1128/JB.183.16.4927-4931.2001
ZHIGANG XIE, FANG MIN, RIVAS MARCOS P, FAULKNER ALEXANDER J, STERNWEIS PAUL C, ENGEBRECHT JOANNE, BANKAITIS VYTAS A, MAJERUS PHILI: "Phospholipase D activity is required for suppression of yeast phosphatidylinositol transfer protein defects Edited by", PROC NATL ACAD SCI, vol. 95, no. 25, 1 October 1998 (1998-10-01), pages 12346 - 12351, XP055715710
SHEN HAIFA, HEACOCK PHILIP N, CLANCEY CONSTANCE J, DOWHAN WILLIAM: "The CDS1 Gene Encoding CDP-diacylglycerol Synthase In Saccharomyces cerevisiae Is Essential for Cell Growth", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 271, no. 2, 12 January 1996 (1996-01-12), US , pages 789 - 795, XP055858905, ISSN: 0021-9258, DOI: 10.1074/jbc.271.2.789
KELLEY MICHAEL J, CARMAN GEORGE M: "Purification and Characterization of CDP-Diacylglycerol Synthase from Saccharomyces cerevisiae", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 262, no. 30, 25 October 1987 (1987-10-25), pages 14563 - 14570, XP055858913
MIN-SEOK RHO, KAWAMATA YUJI, NAKAMURA ' HIDEMITSU, OHTA AKINORI, TAKAGI MASAMICHI: "Isolation and Characterization of ECT1 Gene Encoding CTP: Phosphoethanolamine Cytidylyltransferase of Saccharomyces cerevisiae", J. BIOCHEM, vol. 120, 1 January 1996 (1996-01-01), pages 1040 - 1047, XP055858916
ZHANG BAICHEN, WATTS KRISTIN M., HODGE DANA, KEMP LISA M., HUNSTAD DAVID A., HICKS LESLIE M., ODOM AUDREY R.: "A Second Target of the Antimalarial and Antibacterial Agent Fosmidomycin Revealed by Cellular Metabolic Profiling", BIOCHEMISTRY, vol. 50, no. 17, 3 May 2011 (2011-05-03), pages 3570 - 3577, XP055858921, ISSN: 0006-2960, DOI: 10.1021/bi200113y
NEUMANN MEINA, MITTELSTÄDT GERD, SEDUK FARIDA, IOBBI-NIVOL CHANTAL, LEIMKÜHLER SILKE: "MocA Is a Specific Cytidylyltransferase Involved in Molybdopterin Cytosine Dinucleotide Biosynthesis in Escherichia coli", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 284, no. 33, 1 August 2009 (2009-08-01), US , pages 21891 - 21898, XP055858942, ISSN: 0021-9258, DOI: 10.1074/jbc.M109.008565
STROHMAIER H, REMLER P, RENNER W, HÖGENAUER G: "Expression of genes kdsA and kdsB involved in 3-deoxy-D-manno-octulosonic acid metabolism and biosynthesis of enterobacterial lipopolysaccharide is growth phase regulated primarily at the transcriptional level in Escherichia coli K-12", JOURNAL OF BACTERIOLOGY, vol. 177, no. 15, 1 August 1995 (1995-08-01), US , pages 4488 - 4500, XP055858947, ISSN: 0021-9193, DOI: 10.1128/jb.177.15.4488-4500.1995
TOMARI YUKIHIDE, SUZUKI TSUTOMU, WATANABE KIMITSUNA, UEDA TAKUYA: "The role of tightly bound ATP in Escherichia coli tRNA nucleotidyltransferase : ATP in CCA-adding enzyme", GENES TO CELLS, vol. 5, no. 9, 1 September 2000 (2000-09-01), GB , pages 689 - 698, XP055858951, ISSN: 1356-9597, DOI: 10.1046/j.1365-2443.2000.00360.x
DATABASE Protein NCBI; 27 February 2015 (2015-02-27), "CTP:phosphocholine cytidylyltransferase, putative [Candida dubliniensi CD36]", XP055858955, Database accession no. CAX41949.1
REAVES MARSHALL LOUIS; YOUNG BRIAN D.; HOSIOS AARON M.; XU YI-FAN; RABINOWITZ JOSHUA D.: "Pyrimidine homeostasis is accomplished by directed overflow metabolism", NATURE, vol. 500, no. 7461, 31 July 2013 (2013-07-31), London, pages 237 - 241, XP037228000, ISSN: 0028-0836, DOI: 10.1038/nature12445
THALLER M C, ET AL.: "IDENTIFICATION OF THE GENE (APHA) ENCODING THE CLASS B ACID PHOSPHATASE/PHOSPHOTRANSFERASE OF ESCHERICHIA COLI MG1655 AND CHARACTERIZATION OF ITS PRODUCT", FEMS MICROBIOLOGY LETTERS, vol. 146, no. 2, 1 January 1997 (1997-01-01), pages 191 - 198, XP001024380, ISSN: 0378-1097, DOI: 10.1016/S0378-1097(96)00474-0
WEISS BERNARD: "YjjG, a dUMP Phosphatase, Is Critical for Thymine Utilization by Escherichia coli K-12", JOURNAL OF BACTERIOLOGY, vol. 189, no. 5, 1 March 2007 (2007-03-01), US , pages 2186 - 2189, XP055858929, ISSN: 0021-9193, DOI: 10.1128/JB.01645-06
BULAWA C E, RAETZ C R H: "ISOLATION AND CHARACTERIZATION OF ESCHERICHIA-COLI STRAINS DEFECTIVE IN CDP-DIGLYCERIDE HYDROLASE", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 259, no. 18, 25 September 1984 (1984-09-25), US , pages 11257 - 11264, XP002272208
RILEY, MONICA: "Functions of the Gene Products of Escherichia coli ", MICROBIOLOGICAL REVIEWS, vol. 57, no. 4, 1 December 1993 (1993-12-01), pages 862 - 952, XP055858748
KAKEHI M, USUDA Y, TABIRA Y, SUGIMOTO S: "Complete deficiency of 5'-nucleotidase activity in Escherichia coli leads to loss of growth on purine nucleotides but not of their excretion", JOURNAL OF MOLECULAR MICROBIOLOGY AND BIOTECHNOLOGY, vol. 13, no. 1-3, 1 August 2007 (2007-08-01), CH , pages 96 - 104, XP008103067, ISSN: 1464-1801, DOI: 10.1159/000103601
KIM JIN-SOOK, KOO BONG-SEONG, HYUN HYUNG-HWAN, LEE HYEON-CHEOL: "Deoxycytidine production by a metabolically engineered Escherichia coli strain", MICROBIAL CELL FACTORIES, vol. 14, no. 1, 98, 1 December 2015 (2015-12-01), XP055858936, DOI: 10.1186/s12934-015-0291-8
SHOJI SHIROTA, AGR BIOL CHEN, vol. 35, no. 3, 1975, pages 1469 - 1474
TAKATA J, FERMEM TECHNOL, vol. 60, no. 5, 1982, pages 431 - 437
QIU WEIRAN, CHINESE JOURNAL OF BIOCHEMICAL PHARMACEUTICS, vol. 62, no. 4, 1992, pages 37 - 39
YU DONGSHENG, JOURNAL OF WUXI UNIVERSITY OF LIGHT INDUSTRY, vol. 21, no. 3, 2002, pages 277 - 280
YING HANJIE: "GENETICALLY ENGINEERED BACTERIUM STRAIN EXPRESSING CHOLINE KINASE AND PHOSPHOCHOLINE CYTIDYLYLTRANSFERASE AND CONSTRUCTION", METHOD AND APPLICATION THEREOF, 2015
TSUKAGOSHI Y, J BACTERIOL., vol. 173, no. 6, 1991, pages 2134 - 6
CARTER, J LIPID RES, vol. 7, no. 5, 1966, pages 678 - 83
VISEDO GONZALEZ, BIOCHEM J, vol. 260, no. 1, 1989, pages 299 - 301
ROHDICH, PROC NATL ACAD SCI USA, vol. 96, no. 21, 1999, pages 11758 - 63
NEUMANN, J BIOL CHEM, vol. 284, no. 33, 2009, pages 21891 - 8
GHALAMBOR, J BIOL CHEM 1966, vol. 241, no. 13, 1966, pages 3216 - 21
SHI, EMBO J, vol. 17, no. 11, 1998, pages 3197 - 206
DENAPAITE D, PLOS ONE, vol. 5, no. 2, 2010, pages e9426
CHANG, MPLOS ONE, vol. 11, no. 10, 2016, pages e165006
GADDA, APPL ENVIRON MICROBIOL, vol. 69, no. 4, 2003, pages 2126 - 32
LORD, BIOCHIM BIOPHYS ACTA, vol. 267, no. 2, 1972, pages 227 - 37
SUNG, BIOCHEM. J., vol. 105, 1967, pages 497
IYENGAR A, BIOCHEM J., vol. 369, 2003, pages 497 - 507
DEVROEDE N, J BACTERIOL., vol. 188, no. 9, 2006, pages 3236 - 45
KIM, MICROB CELL FACT, vol. 14, 2015, pages 98
DELANNAY S, J MOL BIOL., vol. 286, no. 4, 1999, pages 1217 - 28
COUDRAY L, BIOORG MED CHEM., vol. 17, no. 22, 2009, pages 7680 - 9
KAJ FRANK JENSEN, JOURNAL OF BACTERIOLOGY, 1993, pages 3401 - 3407
J. BROSIUSM. ERFLE: "J. Storella Spacing of the -10 and -35 regions in the tac promoter Effect on its in vivo activity", J. BIOL. CHEM., vol. 260, 1985, pages 3539 - 3541, XP002674569
WALZ, A.PIRROTTA, V.: "Sequence of the PR promoter of phage X", NATURE, vol. 254, 1975, pages 118 - 121
SHIMAOKA, J BIOSCI BIOENG, vol. 103, no. 3, 2007, pages 255 - 61
MEYER P, J BIOL CHEM., vol. 283, no. 51, 2008, pages 36011 - 8
DATSENKO KA, PROC NATL ACAD SCI USA, vol. 97, no. 12, 2000, pages 6640 - 6664
BABA T., MOL SYST BIOL, vol. 2, no. 1, 2006, pages 0008
J. SAMBROOK, MOLECULAR CLONING: A LABORATORY MANUAL, 2002, pages 1595
LIU YINGMIAO; WANG JUNZHI; XU CHONGMAO; CHEN YONG; YANG JUNJIE; LIU DONG; NIU HUANQING; JIANG YU; YANG SHENG; YING HANJIE: "Efficient multi-enzyme-catalyzed CDP-choline production driven by an ATP donor module", APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, vol. 101, no. 4, 13 October 2016 (2016-10-13), Berlin/Heidelberg, pages 1409 - 1417, XP036137870, ISSN: 0175-7598, DOI: 10.1007/s00253-016-7874-0
ALVES-PEREIRA ISABEL, CANALES JOSÉ, CABEZAS ALICIA, MARTÍN CORDERO PALOMA, COSTAS MARÍA JESÚS, CAMESELLE JOSÉ CARLOS: "CDP-Alcohol Hydrolase, a Very Efficient Activity of the 5′-Nucleotidase/UDP-Sugar Hydrolase Encoded by the ushA Gene of Yersinia intermedia and Escherichia coli", JOURNAL OF BACTERIOLOGY, vol. 190, no. 18, 15 September 2008 (2008-09-15), US , pages 6153 - 6161, XP055858774, ISSN: 0021-9193, DOI: 10.1128/JB.00658-08
BULAWA CHRISTINE E, HERMES JEFFREY D, RAETZ CHRISTIAN R H: "Chloroform-soluble Nucleotides in Escherichia coli - ROLE OF CDP-DIGLYCERIDE IN THE ENZYMATIC CYTIDYLYLATION OF PHOSPHOMONOESTER ACCEPTORS", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 258, no. 24, 1 December 1983 (1983-12-01), pages 14974 - 14980, XP055858800
IMPERIAL SANTIAGO, CENTELLES JOSEP J.: "Enzyme Kinetic Equations of Irreversible and Reversible Reactions in Metabolism", JOURNAL OF BIOSCIENCES AND MEDICINES, vol. 02, no. 04, 1 January 2014 (2014-01-01), pages 24 - 29, XP055858819, ISSN: 2327-5081, DOI: 10.4236/jbm.2014.24005
ANDRESEN PER A, KAASEN INGA, STYRVOLD OLAF B, BOULNOIS GRAHAM, STROM ARNE R: "Molecular Cloning, Physical Mapping and Expression of the bet Genes Governing the Osmoregulatory Choline-Glycine Betaine Pathway of Escherichia coli", JOURNAL OF GENERAL MICROBIOLOGY, vol. 134, 1 January 1988 (1988-01-01), pages 1737 - 1746, XP055858825
INOUYE H, MICHAELIS S, WRIGHT A, BECKWITH J: "Cloning and restriction mapping of the alkaline phosphatase structural gene (phoA) of Escherichia coli and generation of deletion mutants in vitro", JOURNAL OF BACTERIOLOGY, vol. 146, no. 2, 1 May 1981 (1981-05-01), US , pages 668 - 675, XP055858832, ISSN: 0021-9193, DOI: 10.1128/jb.146.2.668-675.1981
AMINI, N., MCKELVIE, I.: "An enzymatic flow analysis method for the determination of phosphatidylcholine in sediment pore waters and extracts", TALANTA, vol. 66, no. 2, 15 April 2005 (2005-04-15), NL , pages 445 - 452, XP004872767, ISSN: 0039-9140, DOI: 10.1016/j.talanta.2004.11.001
FORLEO C., M. BENVENUTI, V. CALDERONE, S. SCHIPPA, J.-D. DOCQUIER, M. C. THALLER, G. M. ROSSOLINI AND S. MANGANI: "Expression, purification, crystallization and preliminary X-ray characterization of the class B acid phosphatase (AphA) from Escherichia coli", ACTA CRYSTALLOGRAPHICA, vol. D59, 1 January 2003 (2003-01-01), pages 1058 - 1060, XP055858853, ISSN: 0907-4449, DOI: 10.1107/S0907444903006826
DOMENECH CARLOS E, LISA TERESITA A, SALVANO MARIO A, GARRIDO MÓNICA N: "Pseudomonas aeruginosa acid phosphatase - Activation by divalent cations and inhibition by aluminium ion", FEBS LETTERS, vol. 299, no. 1, 1 March 1992 (1992-03-01), NL , pages 96 - 98, XP055858859, ISSN: 0014-5793, DOI: 10.1016/0014-5793(92)80108-S
KIM K ET AL: "Isolation and characterization of the Saccharomyces cerevisiae EKI1 gene encoding ethanolamine kinase.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 274, no. 21, 21 May 1999 (1999-05-21), US , pages 14857 - 14866, XP002219583, ISSN: 0021-9258, DOI: 10.1074/jbc.274.21.14857
ROCK CHARLES O., HEATH RICHARD J., PARK HEE-WON, JACKOWSKI SUZANNE: "The licC Gene of Streptococcus pneumoniae Encodes a CTP:Phosphocholine Cytidylyltransferase", JOURNAL OF BACTERIOLOGY, vol. 183, no. 16, 15 August 2001 (2001-08-15), US , pages 4927 - 4931, XP055858868, ISSN: 0021-9193, DOI: 10.1128/JB.183.16.4927-4931.2001
ZHIGANG XIE, FANG MIN, RIVAS MARCOS P, FAULKNER ALEXANDER J, STERNWEIS PAUL C, ENGEBRECHT JOANNE, BANKAITIS VYTAS A, MAJERUS PHILI: "Phospholipase D activity is required for suppression of yeast phosphatidylinositol transfer protein defects Edited by", PROC NATL ACAD SCI, vol. 95, no. 25, 1 October 1998 (1998-10-01), pages 12346 - 12351, XP055715710
SHEN HAIFA, HEACOCK PHILIP N, CLANCEY CONSTANCE J, DOWHAN WILLIAM: "The CDS1 Gene Encoding CDP-diacylglycerol Synthase In Saccharomyces cerevisiae Is Essential for Cell Growth", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 271, no. 2, 12 January 1996 (1996-01-12), US , pages 789 - 795, XP055858905, ISSN: 0021-9258, DOI: 10.1074/jbc.271.2.789
KELLEY MICHAEL J, CARMAN GEORGE M: "Purification and Characterization of CDP-Diacylglycerol Synthase from Saccharomyces cerevisiae", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 262, no. 30, 25 October 1987 (1987-10-25), pages 14563 - 14570, XP055858913
MIN-SEOK RHO, KAWAMATA YUJI, NAKAMURA ' HIDEMITSU, OHTA AKINORI, TAKAGI MASAMICHI: "Isolation and Characterization of ECT1 Gene Encoding CTP: Phosphoethanolamine Cytidylyltransferase of Saccharomyces cerevisiae", J. BIOCHEM, vol. 120, 1 January 1996 (1996-01-01), pages 1040 - 1047, XP055858916
ZHANG BAICHEN, WATTS KRISTIN M., HODGE DANA, KEMP LISA M., HUNSTAD DAVID A., HICKS LESLIE M., ODOM AUDREY R.: "A Second Target of the Antimalarial and Antibacterial Agent Fosmidomycin Revealed by Cellular Metabolic Profiling", BIOCHEMISTRY, vol. 50, no. 17, 3 May 2011 (2011-05-03), pages 3570 - 3577, XP055858921, ISSN: 0006-2960, DOI: 10.1021/bi200113y
NEUMANN MEINA, MITTELSTÄDT GERD, SEDUK FARIDA, IOBBI-NIVOL CHANTAL, LEIMKÜHLER SILKE: "MocA Is a Specific Cytidylyltransferase Involved in Molybdopterin Cytosine Dinucleotide Biosynthesis in Escherichia coli", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 284, no. 33, 1 August 2009 (2009-08-01), US , pages 21891 - 21898, XP055858942, ISSN: 0021-9258, DOI: 10.1074/jbc.M109.008565
STROHMAIER H, REMLER P, RENNER W, HÖGENAUER G: "Expression of genes kdsA and kdsB involved in 3-deoxy-D-manno-octulosonic acid metabolism and biosynthesis of enterobacterial lipopolysaccharide is growth phase regulated primarily at the transcriptional level in Escherichia coli K-12", JOURNAL OF BACTERIOLOGY, vol. 177, no. 15, 1 August 1995 (1995-08-01), US , pages 4488 - 4500, XP055858947, ISSN: 0021-9193, DOI: 10.1128/jb.177.15.4488-4500.1995
TOMARI YUKIHIDE, SUZUKI TSUTOMU, WATANABE KIMITSUNA, UEDA TAKUYA: "The role of tightly bound ATP in Escherichia coli tRNA nucleotidyltransferase : ATP in CCA-adding enzyme", GENES TO CELLS, vol. 5, no. 9, 1 September 2000 (2000-09-01), GB , pages 689 - 698, XP055858951, ISSN: 1356-9597, DOI: 10.1046/j.1365-2443.2000.00360.x
DATABASE Protein NCBI; 27 February 2015 (2015-02-27), "CTP:phosphocholine cytidylyltransferase, putative [Candida dubliniensi CD36]", XP055858955, Database accession no. CAX41949.1
REAVES MARSHALL LOUIS; YOUNG BRIAN D.; HOSIOS AARON M.; XU YI-FAN; RABINOWITZ JOSHUA D.: "Pyrimidine homeostasis is accomplished by directed overflow metabolism", NATURE, vol. 500, no. 7461, 31 July 2013 (2013-07-31), London, pages 237 - 241, XP037228000, ISSN: 0028-0836, DOI: 10.1038/nature12445
THALLER M C, ET AL.: "IDENTIFICATION OF THE GENE (APHA) ENCODING THE CLASS B ACID PHOSPHATASE/PHOSPHOTRANSFERASE OF ESCHERICHIA COLI MG1655 AND CHARACTERIZATION OF ITS PRODUCT", FEMS MICROBIOLOGY LETTERS, vol. 146, no. 2, 1 January 1997 (1997-01-01), pages 191 - 198, XP001024380, ISSN: 0378-1097, DOI: 10.1016/S0378-1097(96)00474-0
WEISS BERNARD: "YjjG, a dUMP Phosphatase, Is Critical for Thymine Utilization by Escherichia coli K-12", JOURNAL OF BACTERIOLOGY, vol. 189, no. 5, 1 March 2007 (2007-03-01), US , pages 2186 - 2189, XP055858929, ISSN: 0021-9193, DOI: 10.1128/JB.01645-06
BULAWA C E, RAETZ C R H: "ISOLATION AND CHARACTERIZATION OF ESCHERICHIA-COLI STRAINS DEFECTIVE IN CDP-DIGLYCERIDE HYDROLASE", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 259, no. 18, 25 September 1984 (1984-09-25), US , pages 11257 - 11264, XP002272208
RILEY, MONICA: "Functions of the Gene Products of Escherichia coli ", MICROBIOLOGICAL REVIEWS, vol. 57, no. 4, 1 December 1993 (1993-12-01), pages 862 - 952, XP055858748
KAKEHI M, USUDA Y, TABIRA Y, SUGIMOTO S: "Complete deficiency of 5'-nucleotidase activity in Escherichia coli leads to loss of growth on purine nucleotides but not of their excretion", JOURNAL OF MOLECULAR MICROBIOLOGY AND BIOTECHNOLOGY, vol. 13, no. 1-3, 1 August 2007 (2007-08-01), CH , pages 96 - 104, XP008103067, ISSN: 1464-1801, DOI: 10.1159/000103601
KIM JIN-SOOK, KOO BONG-SEONG, HYUN HYUNG-HWAN, LEE HYEON-CHEOL: "Deoxycytidine production by a metabolically engineered Escherichia coli strain", MICROBIAL CELL FACTORIES, vol. 14, no. 1, 98, 1 December 2015 (2015-12-01), XP055858936, DOI: 10.1186/s12934-015-0291-8
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