Title:
RECOMBINANT MICROORGANISM WITH INCREASED PRODUCTIVITY OF 2,3-BUTANEDIOL, AND METHOD FOR PRODUCING 2,3-BUTANEDIOL USING SAME
Document Type and Number:
WIPO Patent Application WO/2014/148754
Kind Code:
A1
Abstract:
The present invention relates to a recombinant microorganism with increased productivity of 2,3-butanediol, wherein a pathway for converting pyruvate to acetyl-CoA, a pathway for converting pyruvate to formic acid, or a pathway for converting pyruvate to lactate is inhibited in a microorganism having acetyl-CoA and lactate biosynthetic pathways.
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Inventors:
PARK JONG-MYOUNG (KR)
SONG HYO-HAK (KR)
YANG TAEK-HO (KR)
SONG HYO-HAK (KR)
YANG TAEK-HO (KR)
Application Number:
PCT/KR2014/001920
Publication Date:
September 25, 2014
Filing Date:
March 07, 2014
Export Citation:
Assignee:
GS CALTEX CORP (KR)
International Classes:
C12N15/52; C12N1/21; C12P7/16
Foreign References:
| US20100112655A1 | 2010-05-06 | |||
| KR20090025902A | 2009-03-11 |
Other References:
CELINSKA, E. ET AL.: "Biotechnological production of 2, 3-butanediol-Current state and prospects.", BIOTECHNOLOGY ADVANCES, vol. 27, 2009, pages 715 - 725, XP027205958
NIELSEN, D. R. ET AL.: "Metabolic engineering of acetoin and meso-2, 3-butanediol biosynthesis in E. coli.", BIOTECHNOLOGY JOURNAL, vol. 5, 2010, pages 274 - 284, XP055024039
WU, H. ET AL.: "Improved Succinic Acid Production in the Anaerobic Culture of an Escherichia coli pfiB ldhA Double Mutant as a Result of Enhanced Anaplerotic Activities in the Preceding Aerobic Culture.", APPLIED AND ENVIRONMENTAL MICROBIOLOGY, vol. 73, no. 24, December 2007 (2007-12-01), pages 7837 - 7843, XP008136337
JI ET AL., BIOTECHNOL. ADV., vol. 29, 2011, pages 351
CELINSKA ET AL., BIOTECHNOL. ADV., vol. 27, 2009, pages 715
MADDOX IS, BIOTECHNOL., vol. 6, 1996, pages 269
CHANDEL ET AL., SUSTAINABLE BIOTECHNOL., 2010, pages 63
JANSEN ET AL., BIOTECHNOL. BIOENG., vol. 26, 1984, pages 362
JANSEN ET AL., ADV. BIOCHEM. ENG., vol. 27, 1983, pages 85
JI ET AL., BIORESOUR. TECHNOL., vol. 100, 2009, pages 3410
NAKASHIMADA ET AL., J. BIOSCI. BIOENG., vol. 90, 2000, pages 661
NAKASHIMADA ET AL., BIOTECHNOL. LETT., vol. 20, 1998, pages 1133
JI ET AL., BIOTECHNOL. LETT., vol. 30, 2008, pages 731
MA ET AL., APPL. MICROBIOL. BIOTECHNOL., vol. 82, 2009, pages 49
JI ET AL., APPL. MICROBIOL. BIOTECHNOL, vol. 85, 2010, pages 1751
NIELSEN, D. R. ET AL.: "Metabolic engineering of acetoin and meso-2, 3-butanediol biosynthesis in E. coli.", BIOTECHNOLOGY JOURNAL, vol. 5, 2010, pages 274 - 284, XP055024039
WU, H. ET AL.: "Improved Succinic Acid Production in the Anaerobic Culture of an Escherichia coli pfiB ldhA Double Mutant as a Result of Enhanced Anaplerotic Activities in the Preceding Aerobic Culture.", APPLIED AND ENVIRONMENTAL MICROBIOLOGY, vol. 73, no. 24, December 2007 (2007-12-01), pages 7837 - 7843, XP008136337
JI ET AL., BIOTECHNOL. ADV., vol. 29, 2011, pages 351
CELINSKA ET AL., BIOTECHNOL. ADV., vol. 27, 2009, pages 715
MADDOX IS, BIOTECHNOL., vol. 6, 1996, pages 269
CHANDEL ET AL., SUSTAINABLE BIOTECHNOL., 2010, pages 63
JANSEN ET AL., BIOTECHNOL. BIOENG., vol. 26, 1984, pages 362
JANSEN ET AL., ADV. BIOCHEM. ENG., vol. 27, 1983, pages 85
JI ET AL., BIORESOUR. TECHNOL., vol. 100, 2009, pages 3410
NAKASHIMADA ET AL., J. BIOSCI. BIOENG., vol. 90, 2000, pages 661
NAKASHIMADA ET AL., BIOTECHNOL. LETT., vol. 20, 1998, pages 1133
JI ET AL., BIOTECHNOL. LETT., vol. 30, 2008, pages 731
MA ET AL., APPL. MICROBIOL. BIOTECHNOL., vol. 82, 2009, pages 49
JI ET AL., APPL. MICROBIOL. BIOTECHNOL, vol. 85, 2010, pages 1751
Attorney, Agent or Firm:
DAE-A INTELLECTUAL PROPERTY CONSULTING (KR)
특허법인 대아 (KR)
특허법인 대아 (KR)
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