Title:
RECOMBINANT MICROORGANISMS HAVING TEREPHTHALIC ACID PRODUCTIVITY, AND TEREPHTHALIC ACID PREPARATION METHOD USING SAME
Document Type and Number:
WIPO Patent Application WO/2015/190632
Kind Code:
A1
Abstract:
The present invention relates to recombinant microorganisms having terephthalic acid productivity and a terephthalic acid preparation method using same and particularly to: a recombinant microorganism for terephthalic acid production from p-xylene having, introduced therein, xlMA, xylC, tsaMB, tsaC, and tsaD, which are genes for coding enzymes involved in a terephthalic acid metabolic pathway; a recombinant microorganism for terephthalic acid production from p-toluic acid having tsaMB, tsaC, and tsaD introduced therein; and a terephthalic acid preparation method using same. The recombinant microorganisms for terephthalic acid production according to the present invention, prepared by means of the metabolic engineering of microorganisms having no terephthalic acid productivity, allow the preparation of terephthalic acid purely by biological processes without chemical catalytic reactions from renewable carbon-cycle biomass and thus are useful as microorganisms for the industrial production of terephthalic acid.
Inventors:
LEE SANG YUP (KR)
LUO ZIWEI (KR)
LUO ZIWEI (KR)
Application Number:
PCT/KR2014/005186
Publication Date:
December 17, 2015
Filing Date:
June 12, 2014
Export Citation:
Assignee:
KOREA ADVANCED INST SCI & TECH (KR)
International Classes:
C12N1/21
Domestic Patent References:
| WO2013109865A2 | 2013-07-25 |
Foreign References:
| US6187569B1 | 2001-02-13 | |||
| KR20020060217A | 2002-07-16 | |||
| KR20050071188A | 2005-07-07 | |||
| US20030170836A1 | 2003-09-11 |
Other References:
MORENO, RENATA ET AL.: "The Crc global regulator inhibits the Pseudomonas putida pWWO toluene/xylene assimilation pathway by repressing the translation of regulatory and structural genes", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 285, no. 32, 2010, pages 24412 - 24419, XP055242639
BUHLER, BRUNO ET AL.: "Xylene monooxygenase catalyzes the multistep oxygenation of toluene and pseudocumene to corresponding alcohols, aldehydes, and acids in Escherichia coli JM101", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 275, no. 14, 2000, pages 10085 - 10092, XP002166422
JUNKER, FRANK ET AL.: "Characterization of the p-toluenesulfonate operon tsa MBCD and tsaR in Comamonas testosteroni T-2", JOURNAL OF BACTERIOLOGY, vol. 179, no. 3, 1997, pages 919 - 927, XP055242640
BUHLER, BRUNO ET AL.: "Xylene monooxygenase catalyzes the multistep oxygenation of toluene and pseudocumene to corresponding alcohols, aldehydes, and acids in Escherichia coli JM101", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 275, no. 14, 2000, pages 10085 - 10092, XP002166422
JUNKER, FRANK ET AL.: "Characterization of the p-toluenesulfonate operon tsa MBCD and tsaR in Comamonas testosteroni T-2", JOURNAL OF BACTERIOLOGY, vol. 179, no. 3, 1997, pages 919 - 927, XP055242640
Attorney, Agent or Firm:
LEE, Cheo Young et al. (KR)
이처영 (KR)
이처영 (KR)
Download PDF: