RECOMBINANT NOVEL CORONAVIRUS PROTEIN VACCINE, AND PREPARATION METHOD AND USE THEREOF

Title:

RECOMBINANT NOVEL CORONAVIRUS PROTEIN VACCINE, AND PREPARATION METHOD AND USE THEREOF

Document Type and Number:

WIPO Patent Application WO/2023/138334

Kind Code:

A1

Abstract:

Provided is a recombinant novel coronavirus protein, comprising at least two artificially-constructed non-natural RBD fragments; a recombinant vaccine using same as a target antigen has the capacity for broad-spectrum protection across epidemic strains. The present invention achieves a polyvalent broad-spectrum protection effect.

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Inventors:

LI QIMING (CN)
ZHANG JING (CN)
LIANG YU (CN)
SU JIGUO (CN)
DU LIFANG (CN)
TANG FANG (CN)
SHAO SHUAI (CN)
ZHANG XUEFENG (CN)
LEI ZEHUA (CN)
LIU ZHAOMING (CN)
HAN ZIBO (CN)
LIU NING (CN)
JIN YUQIN (CN)
ZHANG HAO (CN)
HOU JUNWEI (CN)
HOU YANAN (CN)
MA ZHIJING (CN)
CHEN SHI (CN)
ZHENG FAN (CN)
SHEN FUJIE (CN)

Application Number:

PCT/CN2022/142937

Publication Date:

July 27, 2023

Filing Date:

December 28, 2022

Export Citation:

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Assignee:

NAT VACCINE AND SERUM INSTITUTE NVSI (CN)

International Classes:

C07K14/165; A61K39/215; A61P31/14; C07K19/00; C12N5/10; C12N15/50; C12N15/62; C12N15/85

Foreign References:

CN113292640A	2021-08-24
CN113817029A	2021-12-21
CN113861278A	2021-12-31
CN114478718A	2022-05-13
CN113461787A	2021-10-01

Other References:

WANG RUI, CHEN JIAHUI, GAO KAIFU, WEI GUO-WEI: "Vaccine-escape and fast-growing mutations in the United Kingdom, the United States, Singapore, Spain, India, and other COVID-19-devastated countries", GENOMICS, ACADEMIC PRESS, SAN DIEGO., US, vol. 113, no. 4, 1 July 2021 (2021-07-01), US , pages 2158 - 2170, XP093079725, ISSN: 0888-7543, DOI: 10.1016/j.ygeno.2021.05.006
HE XUEMEI, HONG WEIQI, PAN XIANGYU, LU GUANGWEN, WEI XIAWEI: "SARS‐CoV‐2 Omicron variant: Characteristics and prevention", MEDCOMM, vol. 2, no. 4, 1 December 2021 (2021-12-01), pages 838 - 845, XP093019879, ISSN: 2688-2663, DOI: 10.1002/mco2.110

Attorney, Agent or Firm:

CONICESS INTELLECTUAL PROPERTY AGENCY OFFICE (CN)

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