Title:
RECOMBINANT PRO-ACTIVIN A PROTEIN
Document Type and Number:
WIPO Patent Application WO/2019/181910
Kind Code:
A1
Abstract:
Provided is a recombinant pro-activin A protein that has human activin A activity. Also provided is a novel method for producing human activin A. The present invention pertains to a recombinant pro-activin A protein containing the mature sequence of human activin A and non-human activin A prodomain, said recombinant pro-activin A protein being different from a pro-activin A protein occurring in nature. The present invention also pertains to a method for producing human activin A using the aforesaid recombinant pro-activin A protein.
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Inventors:
HIRANO HIROTO (JP)
ITO KENICHIRO (JP)
ITO KENICHIRO (JP)
Application Number:
PCT/JP2019/011357
Publication Date:
September 26, 2019
Filing Date:
March 19, 2019
Export Citation:
Assignee:
AJINOMOTO KK (JP)
International Classes:
C12N15/12; C07K1/12; C07K14/475; C12N15/82; C12P21/02; C12N5/10
Domestic Patent References:
| WO2002099067A2 | 2002-12-12 | |||
| WO1997023638A1 | 1997-07-03 |
Foreign References:
| JPH07265083A | 1995-10-17 |
Other References:
WANG X. ET AL.: "Structure and activation of pro-activin A", NAT. COMMUN., vol. 7, 4 July 2016 (2016-07-04), pages 1 - 11, XP055642542
GRAY A.M. ET AL.: "Requirement for activin A and transforming growth factor- beta 1 pro-regions in homodimer assembly", SCIENCE, vol. 247, no. 4948, 16 March 1990 (1990-03-16), pages 1328 - 1330, XP001109030
XUELU WANG ET AL., NATURE COMMUNICATIONS, vol. 7, 2016, pages 12052
BRAVO, D. A.GLEASON, J. B.SANCHEZ, R. I.ROTH, R. A.FULLER, R. S.: "Accurate and efficient cleavage of the human insulin proreceptor by the human proprotein-processing protease furin. Characterization and kinetic parameters using the purified, secreted soluble protease expressed by a recombinant baculovirus", J. BIOL. CHEM., vol. 269, 1994, pages 25830 - 25837, XP002115941
GRAY A.M. ET AL.: "Requirement for activin A and transforming growth factor- beta 1 pro-regions in homodimer assembly", SCIENCE, vol. 247, no. 4948, 16 March 1990 (1990-03-16), pages 1328 - 1330, XP001109030
XUELU WANG ET AL., NATURE COMMUNICATIONS, vol. 7, 2016, pages 12052
BRAVO, D. A.GLEASON, J. B.SANCHEZ, R. I.ROTH, R. A.FULLER, R. S.: "Accurate and efficient cleavage of the human insulin proreceptor by the human proprotein-processing protease furin. Characterization and kinetic parameters using the purified, secreted soluble protease expressed by a recombinant baculovirus", J. BIOL. CHEM., vol. 269, 1994, pages 25830 - 25837, XP002115941
Attorney, Agent or Firm:
TANAKA Shinichiro et al. (JP)
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