Title:
RECOMBINANT PRODUCTION SYSTEMS FOR AROMATIC MOLECULES
Document Type and Number:
WIPO Patent Application WO/2012/178110
Kind Code:
A3
Abstract:
The invention relates to the production of aromatic molecules in prokaryotic and eukaryotic hosts such as E. coli, yeasts, filamentous fungi, algae, microalgae, other plant cells.
More Like This:
Inventors:
BARR PHILIP J (US)
Application Number:
PCT/US2012/043878
Publication Date:
April 11, 2013
Filing Date:
June 22, 2012
Export Citation:
Assignee:
RHO RENEWABLES INC (US)
BARR PHILIP J (US)
BARR PHILIP J (US)
International Classes:
C12N9/10; C12N9/88; C12P7/22
Domestic Patent References:
| WO1998027203A1 | 1998-06-25 |
Other References:
M. P. ARTIGOT ET AL: "Molecular cloning and functional characterization of two CYP619 cytochrome P450s involved in biosynthesis of patulin in Aspergillus clavatus", MICROBIOLOGY, vol. 155, no. 5, 1 May 2009 (2009-05-01), pages 1738 - 1747, XP055040441, ISSN: 1350-0872, DOI: 10.1099/mic.0.024836-0
PACKTER: "Studies on the biosynthesis of quinones in fungi. Incorporation of 6-methylsalicylic acid into fumigatin and related compounds in Aspergillus fumigatus I.M.I. 89353.", BIOCHEMICAL JOURNAL, vol. 97, no. 2, 1 November 1965 (1965-11-01), pages 321 - 332, XP055040445, ISSN: 0264-6021
KLAUS MOSBACH ET AL: "Studies on Lichen Enzymes. Purification and Properties of Orsellinate Decarboxylase Obtained from Lasallia pustulata", EUROPEAN JOURNAL OF BIOCHEMISTRY, vol. 22, no. 4, 1 October 1971 (1971-10-01), pages 485 - 488, XP055040447, ISSN: 0014-2956, DOI: 10.1111/j.1432-1033.1971.tb01567.x
SLATER G P ET AL: "THE DECARBOXYLATION OF 6 METHYL SALICYLIC-ACID BY VALSA-FRIESSI", CANADIAN JOURNAL OF MICROBIOLOGY, NRC RESEARCH PRESS, CA, vol. 19, no. 9, 1 January 1973 (1973-01-01), pages 1169 - 1171, XP009162878, ISSN: 0008-4166
LIGHT ET AL: "6-Methylsalicylic acid decarboxylase from Penicillium patulum", BBA ENZYMOLOGY, ELSEVIER, AMSTERDAM, NL, vol. 191, no. 2, 4 November 1969 (1969-11-04), pages 430 - 438, XP023899039, ISSN: 0005-2744, [retrieved on 19691104], DOI: 10.1016/0005-2744(69)90262-9
KEALEY J T ET AL: "Production of a polyketide natural product in nonpolyketide-producing prokaryotic and eukaryotic hosts", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, US, vol. 95, no. 2, 20 January 1998 (1998-01-20), pages 505 - 509, XP002338563, ISSN: 0027-8424, DOI: 10.1073/PNAS.95.2.505
WEI DING ET AL: "Insights into Bacterial 6-Methylsalicylic Acid Synthase and Its Engineering to Orsellinic Acid Synthase for Spirotetronate Generation", CHEMISTRY & BIOLOGY, vol. 17, no. 5, 1 May 2010 (2010-05-01), pages 495 - 503, XP055040451, ISSN: 1074-5521, DOI: 10.1016/j.chembiol.2010.04.009
SARAH C. MUTKA ET AL: "Metabolic pathway engineering for complex polyketide biosynthesis in Saccharomyces cerevisiae", FEMS YEAST RESEARCH, vol. 6, no. 1, 1 January 2006 (2006-01-01), pages 40 - 47, XP055040452, ISSN: 1567-1356, DOI: 10.1111/j.1567-1356.2005.00001.x
WATTANACHAISAEREEKUL S ET AL: "Production of the polyketide 6-MSA in yeast engineered for increased malonyl-CoA supply", METABOLIC ENGINEERING, ACADEMIC PRESS, US, vol. 10, no. 5, 1 September 2008 (2008-09-01), pages 246 - 254, XP024525628, ISSN: 1096-7176, [retrieved on 20080510], DOI: 10.1016/J.YMBEN.2008.04.005
GABRIEL SCALLIET ET AL: "Biosynthesis of the major scent components 3,5-dimethoxytoluene and 1,3,5-trimethoxybenzene by novel rose O-methyltransferases", FEBS LETTERS, vol. 523, no. 1-3, 1 July 2002 (2002-07-01), pages 113 - 118, XP055040468, ISSN: 0014-5793, DOI: 10.1016/S0014-5793(02)02956-3
PACKTER: "Studies on the biosynthesis of quinones in fungi. Incorporation of 6-methylsalicylic acid into fumigatin and related compounds in Aspergillus fumigatus I.M.I. 89353.", BIOCHEMICAL JOURNAL, vol. 97, no. 2, 1 November 1965 (1965-11-01), pages 321 - 332, XP055040445, ISSN: 0264-6021
KLAUS MOSBACH ET AL: "Studies on Lichen Enzymes. Purification and Properties of Orsellinate Decarboxylase Obtained from Lasallia pustulata", EUROPEAN JOURNAL OF BIOCHEMISTRY, vol. 22, no. 4, 1 October 1971 (1971-10-01), pages 485 - 488, XP055040447, ISSN: 0014-2956, DOI: 10.1111/j.1432-1033.1971.tb01567.x
SLATER G P ET AL: "THE DECARBOXYLATION OF 6 METHYL SALICYLIC-ACID BY VALSA-FRIESSI", CANADIAN JOURNAL OF MICROBIOLOGY, NRC RESEARCH PRESS, CA, vol. 19, no. 9, 1 January 1973 (1973-01-01), pages 1169 - 1171, XP009162878, ISSN: 0008-4166
LIGHT ET AL: "6-Methylsalicylic acid decarboxylase from Penicillium patulum", BBA ENZYMOLOGY, ELSEVIER, AMSTERDAM, NL, vol. 191, no. 2, 4 November 1969 (1969-11-04), pages 430 - 438, XP023899039, ISSN: 0005-2744, [retrieved on 19691104], DOI: 10.1016/0005-2744(69)90262-9
KEALEY J T ET AL: "Production of a polyketide natural product in nonpolyketide-producing prokaryotic and eukaryotic hosts", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, US, vol. 95, no. 2, 20 January 1998 (1998-01-20), pages 505 - 509, XP002338563, ISSN: 0027-8424, DOI: 10.1073/PNAS.95.2.505
WEI DING ET AL: "Insights into Bacterial 6-Methylsalicylic Acid Synthase and Its Engineering to Orsellinic Acid Synthase for Spirotetronate Generation", CHEMISTRY & BIOLOGY, vol. 17, no. 5, 1 May 2010 (2010-05-01), pages 495 - 503, XP055040451, ISSN: 1074-5521, DOI: 10.1016/j.chembiol.2010.04.009
SARAH C. MUTKA ET AL: "Metabolic pathway engineering for complex polyketide biosynthesis in Saccharomyces cerevisiae", FEMS YEAST RESEARCH, vol. 6, no. 1, 1 January 2006 (2006-01-01), pages 40 - 47, XP055040452, ISSN: 1567-1356, DOI: 10.1111/j.1567-1356.2005.00001.x
WATTANACHAISAEREEKUL S ET AL: "Production of the polyketide 6-MSA in yeast engineered for increased malonyl-CoA supply", METABOLIC ENGINEERING, ACADEMIC PRESS, US, vol. 10, no. 5, 1 September 2008 (2008-09-01), pages 246 - 254, XP024525628, ISSN: 1096-7176, [retrieved on 20080510], DOI: 10.1016/J.YMBEN.2008.04.005
GABRIEL SCALLIET ET AL: "Biosynthesis of the major scent components 3,5-dimethoxytoluene and 1,3,5-trimethoxybenzene by novel rose O-methyltransferases", FEBS LETTERS, vol. 523, no. 1-3, 1 July 2002 (2002-07-01), pages 113 - 118, XP055040468, ISSN: 0014-5793, DOI: 10.1016/S0014-5793(02)02956-3
Attorney, Agent or Firm:
BERNHARDT, Jeffrey, P. et al. (LLP1801 Page Mill Road, Suite 11, Palo Alto CA, US)
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