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Title:
RECOMBINANT PROTEIN BODIES AS IMMUNOGEN-SPECIFIC ADJUVANTS
Document Type and Number:
WIPO Patent Application WO/2010/040847
Kind Code:
A3
Abstract:
An immunogen-specif ic adjuvant for a vaccine or inoculum is disclosed. The adjuvant is comprised of particulate recombinant protein body-like assemblies (RPBLAs) that contain a recombinant fusion protein that contains two portions peptide-linked together. A first portion is a protein body-inducing sequence (PBIS) and a second portion is a T-cell stimulating immunogenic polypeptide whose sequence is that of a pathogenic polypeptide sequence present in or induced by a vaccine or inoculum. The adjuvant, when used as an inoculum in a host animal without a prior priming vaccination or inoculation, does not induce production of antibodies or T cell activation to the pathogenic sequence.

Inventors:
RYBICKI EDWAR PETER (ZA)
MEYERS ANN ELIZABETH (ZA)
DEVESA FRANCOIS (FR)
MARZABAL LUNA PABLO (ES)
HITZEROTH INGA ISABEL (ZA)
OEHLSCHLAEGER PETER (DE)
Application Number:
PCT/EP2009/063223
Publication Date:
August 05, 2010
Filing Date:
October 09, 2009
Export Citation:
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Assignee:
ERA BIOTECH SA (ES)
RYBICKI EDWAR PETER (ZA)
MEYERS ANN ELIZABETH (ZA)
DEVESA FRANCOIS (FR)
MARZABAL LUNA PABLO (ES)
HITZEROTH INGA ISABEL (ZA)
OEHLSCHLAEGER PETER (DE)
International Classes:
C07K14/025; A61K39/00; C07K14/16; C07K14/425; C12N15/62
Domestic Patent References:
WO2007096192A22007-08-30
Attorney, Agent or Firm:
ALCONADA RODRÍGUEZ, Agustín (S.L.Avenida de Burgos, 16, Edificio Euromor Madrid, ES)
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