Title:
RECOMBINANT PROTEIN BODIES AS IMMUNOGEN-SPECIFIC ADJUVANTS
Document Type and Number:
WIPO Patent Application WO/2010/040847
Kind Code:
A3
Abstract:
An immunogen-specif ic adjuvant for a vaccine or inoculum is disclosed. The adjuvant is comprised of particulate recombinant protein body-like assemblies (RPBLAs) that contain a recombinant fusion protein that contains two portions peptide-linked together. A first portion is a protein body-inducing sequence (PBIS) and a second portion is a T-cell stimulating immunogenic polypeptide whose sequence is that of a pathogenic polypeptide sequence present in or induced by a vaccine or inoculum. The adjuvant, when used as an inoculum in a host animal without a prior priming vaccination or inoculation, does not induce production of antibodies or T cell activation to the pathogenic sequence.
Inventors:
RYBICKI EDWAR PETER (ZA)
MEYERS ANN ELIZABETH (ZA)
DEVESA FRANCOIS (FR)
MARZABAL LUNA PABLO (ES)
HITZEROTH INGA ISABEL (ZA)
OEHLSCHLAEGER PETER (DE)
MEYERS ANN ELIZABETH (ZA)
DEVESA FRANCOIS (FR)
MARZABAL LUNA PABLO (ES)
HITZEROTH INGA ISABEL (ZA)
OEHLSCHLAEGER PETER (DE)
Application Number:
PCT/EP2009/063223
Publication Date:
August 05, 2010
Filing Date:
October 09, 2009
Export Citation:
Assignee:
ERA BIOTECH SA (ES)
RYBICKI EDWAR PETER (ZA)
MEYERS ANN ELIZABETH (ZA)
DEVESA FRANCOIS (FR)
MARZABAL LUNA PABLO (ES)
HITZEROTH INGA ISABEL (ZA)
OEHLSCHLAEGER PETER (DE)
RYBICKI EDWAR PETER (ZA)
MEYERS ANN ELIZABETH (ZA)
DEVESA FRANCOIS (FR)
MARZABAL LUNA PABLO (ES)
HITZEROTH INGA ISABEL (ZA)
OEHLSCHLAEGER PETER (DE)
International Classes:
C07K14/025; A61K39/00; C07K14/16; C07K14/425; C12N15/62
Domestic Patent References:
WO2007096192A2 | 2007-08-30 |
Attorney, Agent or Firm:
ALCONADA RODRÍGUEZ, Agustín (S.L.Avenida de Burgos, 16, Edificio Euromor Madrid, ES)
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