Title:
RECOMBINANT THYROID STIMULATING HORMONE RECEPTOR PROTEIN, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/045470
Kind Code:
A1
Abstract:
The present invention provides a recombinant thyroid stimulating hormone receptor protein, a preparation method therefor and an application thereof. The recombinant thyroid stimulating hormone receptor protein comprises a TSHR protein extracellular segment and a TSHR protein intracellular segment. The C-terminus of the TSHR protein extracellular segment is linked to the N-terminus of the TSHR protein intracellular segment. The protein achieves extracellular soluble expression, and is high in purity, high in activity and good in stability.
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Inventors:
WANG HAIHONG (CN)
KE QISHEN (CN)
ZOU MENGWEN (CN)
ZHUANG CUIZHEN (CN)
LI LIHUA (CN)
LI HUIPING (CN)
CHEN WEIBIN (CN)
KE SHAOJUN (CN)
ZHANG YIFEI (CN)
LIN QIUMIN (CN)
SONG LIUWEI (CN)
XIONG JUNHUI (CN)
KE QISHEN (CN)
ZOU MENGWEN (CN)
ZHUANG CUIZHEN (CN)
LI LIHUA (CN)
LI HUIPING (CN)
CHEN WEIBIN (CN)
KE SHAOJUN (CN)
ZHANG YIFEI (CN)
LIN QIUMIN (CN)
SONG LIUWEI (CN)
XIONG JUNHUI (CN)
Application Number:
PCT/CN2022/102890
Publication Date:
March 30, 2023
Filing Date:
June 30, 2022
Export Citation:
Assignee:
XIAMEN INNOBIOMAX BIOTECHNOLOGY CO LTD (CN)
XIAMEN INNODX BIOTECH CO LTD (CN)
XIAMEN INNODX BIOTECH CO LTD (CN)
International Classes:
C07K14/72; C07K19/00; G01N33/68
Domestic Patent References:
| WO1991009137A1 | 1991-06-27 | |||
| WO2020185926A1 | 2020-09-17 |
Foreign References:
| CN101928348A | 2010-12-29 | |||
| CN104628843A | 2015-05-20 | |||
| CN1952137A | 2007-04-25 |
Attorney, Agent or Firm:
XIAMEN YUANCHUANG PATENT FIRM (GENERAL PARTNERSHIP) (CN)
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