Title:
RECOMBINANT VECTOR FOR PRODUCING PINOSTILBENE OR PTEROSTILBENE
Document Type and Number:
WIPO Patent Application WO/2018/008979
Kind Code:
A1
Abstract:
The present invention relates to a recombinant vector for producing pinostilbene or pterostilbene, a transformant for producing pinostilbene or pterostilbene, and a method for producing pinostilbene or pterostilbene. The use of the recombinant vector for producing pinostilbene or pterostilbene according to the present invention allows pinostilbene or pterostilbene to be obtained through a single vector system, and is economical, since pinostilbene or pterostilbene is mass-produced even from simple sugars alone via a microbial metabolic pathway. In addition, pinostilbene or pterostilbene produced using the recombinant vector has anticancer, anti-inflammatory, antihyperlipidemic, and antioxidative effects and thus can be beneficially used in the pharmaceutical industry.
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Inventors:
HONG YOUNG SOO (KR)
KANG SUN YOUNG (KR)
HEO KYUNG TAEK (KR)
LEE JAE KYOUNG (KR)
KANG SUN YOUNG (KR)
HEO KYUNG TAEK (KR)
LEE JAE KYOUNG (KR)
Application Number:
PCT/KR2017/007183
Publication Date:
January 11, 2018
Filing Date:
July 05, 2017
Export Citation:
Assignee:
KOREA RES INST BIOSCIENCE & BIOTECHNOLOGY (KR)
International Classes:
C12N15/63; C12N9/10; C12P7/22
Foreign References:
| KR101566692B1 | 2015-11-09 |
Other References:
WANG, YECHUN ET AL.: "Pterostilbene Production by Microorganisms Expressing Resveratrol O-methyltransferase", ANNALS OF MICROBIOLOGY, vol. 65, 2015, pages 817 - 826, XP055336881
JEONG, YU JEONG ET AL.: "Metabolic Engineering for Resveratrol Derivative Biosynthesis in Escherichia Coli", MOLECULES AND CELLS, vol. 38, no. 4, 2015, pages 318 - 326, XP055451963
CHOI, OK SIK ET AL.: "Biosynthesis of Plant-specific Phenylpropanoids by Construction of an Artificial Biosynthetic Pathway in Escherichia Coli", JOURNAL OF INDUSTRIAL MICROBIOLOGY AND BIOTECHNOLOGY, vol. 38, no. 10, 20 March 2011 (2011-03-20), pages 1657 - 1665, XP019955173
DATABASE nucleotide [O] 14 April 2002 (2002-04-14), ARABIDOPSIS THALIANA O-METHYLTRANSFERASE (AT5G54160) MRNA,COMPLETE CDS, XP055451971, Database accession no. AY081565.1
HEO, KYUNG TAEK ET AL.: "De Novo Biosynthesis of Pterostilbene in an Escherichia Coli Strain using a New Resveratrol O-methyltransferase from Arabidopsis", MICROBIAL CELL FACTORIES, vol. 16, no. 30, 15 February 2017 (2017-02-15), pages 1 - 8, XP055451976
JEONG, YU JEONG ET AL.: "Metabolic Engineering for Resveratrol Derivative Biosynthesis in Escherichia Coli", MOLECULES AND CELLS, vol. 38, no. 4, 2015, pages 318 - 326, XP055451963
CHOI, OK SIK ET AL.: "Biosynthesis of Plant-specific Phenylpropanoids by Construction of an Artificial Biosynthetic Pathway in Escherichia Coli", JOURNAL OF INDUSTRIAL MICROBIOLOGY AND BIOTECHNOLOGY, vol. 38, no. 10, 20 March 2011 (2011-03-20), pages 1657 - 1665, XP019955173
DATABASE nucleotide [O] 14 April 2002 (2002-04-14), ARABIDOPSIS THALIANA O-METHYLTRANSFERASE (AT5G54160) MRNA,COMPLETE CDS, XP055451971, Database accession no. AY081565.1
HEO, KYUNG TAEK ET AL.: "De Novo Biosynthesis of Pterostilbene in an Escherichia Coli Strain using a New Resveratrol O-methyltransferase from Arabidopsis", MICROBIAL CELL FACTORIES, vol. 16, no. 30, 15 February 2017 (2017-02-15), pages 1 - 8, XP055451976
Attorney, Agent or Firm:
AHN, So Young (KR)
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