Title:
RECOMBINANT VIRAL VECTORS AND METHODS FOR INDUCING A HETEROSUBTYPIC IMMUNE RESPONSE TO INFLUENZA A VIRUSES
Document Type and Number:
WIPO Patent Application WO/2012/106231
Kind Code:
A3
Abstract:
The present invention relates to recombinant viral vectors and methods of using the recombinant viral vectors to induce an immune response to influenza A viruses. The invention provides recombinant viral vectors based, for example, on the non-replicating modified vaccinia virus Ankara. When administered according to methods of the invention, the recombinant viral vectors are designed to be cross-protective and induce heterosubtypic immunity to influenza A viruses.
Inventors:
FALKNER FALKO-GUENTER (AT)
SCHAEFER BIRGIT (AT)
HESSEL ANNETT (AT)
BARRETT P NOEL (AT)
KREIL THOMAS R (AT)
EHRLICH HARTMUT (AT)
SCHAEFER BIRGIT (AT)
HESSEL ANNETT (AT)
BARRETT P NOEL (AT)
KREIL THOMAS R (AT)
EHRLICH HARTMUT (AT)
Application Number:
PCT/US2012/023085
Publication Date:
September 20, 2012
Filing Date:
January 30, 2012
Export Citation:
Assignee:
BAXTER INT (US)
BAXTER HEALTHCARE SA (CH)
FALKNER FALKO-GUENTER (AT)
SCHAEFER BIRGIT (AT)
HESSEL ANNETT (AT)
BARRETT P NOEL (AT)
KREIL THOMAS R (AT)
EHRLICH HARTMUT (AT)
BAXTER HEALTHCARE SA (CH)
FALKNER FALKO-GUENTER (AT)
SCHAEFER BIRGIT (AT)
HESSEL ANNETT (AT)
BARRETT P NOEL (AT)
KREIL THOMAS R (AT)
EHRLICH HARTMUT (AT)
International Classes:
A61K39/145; C07K14/11; A61K39/00
Domestic Patent References:
| WO2010117786A1 | 2010-10-14 | |||
| WO2008118487A2 | 2008-10-02 |
Other References:
FIERS WALTER ET AL: "M2e-based universal influenza A vaccine", VACCINE, ELSEVIER LTD, GB, vol. 27, no. 45, 23 October 2009 (2009-10-23), pages 6280 - 6283, XP002570554, ISSN: 0264-410X, [retrieved on 20091017], DOI: 10.1016/J.VACCINE.2009.07.007
STEEL JOHN ET AL: "Influenza virus vaccine based on the conserved hemagglutinin stalk domain.", MBIO, vol. 1, no. 1, April 2010 (2010-04-01), XP002676044, ISSN: 2150-7511
SRINIVAS S. RAO ET AL: "Comparative Efficacy of Hemagglutinin, Nucleoprotein, and Matrix 2 Protein Gene-Based Vaccination against H5N1 Influenza in Mouse and Ferret", PLOS ONE, vol. 5, no. 3, 1 January 2010 (2010-01-01), pages E9812 - E9812, XP055027360, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0009812
WU F ET AL: "Heterosubtypic protection conferred by combined vaccination with M2e peptide and split influenza vaccine", VACCINE, vol. 27, no. 43, 9 October 2009 (2009-10-09), pages 6095 - 6101, XP026643909, ISSN: 0264-410X, [retrieved on 20081203], DOI: 10.1016/J.VACCINE.2008.11.037
ZHOU DONGMING ET AL: "A universal influenza A vaccine based on adenovirus expressing matrix-2 ectodomain and nucleoprotein protects mice from lethal challenge.", MOLECULAR THERAPY : THE JOURNAL OF THE AMERICAN SOCIETY OF GENE THERAPY, vol. 18, no. 12, December 2010 (2010-12-01), pages 2182 - 2189, XP002676119, ISSN: 1525-0024
KANG S M ET AL: "Novel vaccines against influenza viruses", VIRUS RESEARCH, vol. 162, no. 1, 1 October 2011 (2011-10-01), pages 31 - 38, XP028115824, ISSN: 0168-1702, [retrieved on 20110929], DOI: 10.1016/J.VIRUSRES.2011.09.037
ANNETT HESSEL ET AL: "A Pandemic Influenza H1N1 Live Vaccine Based on Modified Vaccinia Ankara Is Highly Immunogenic and Protects Mice in Active and Passive Immunizations", PLOS ONE, vol. 5, no. 8, 1 January 2010 (2010-01-01), pages E12217 - E12217, XP055003992, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0012217
STEEL JOHN ET AL: "Influenza virus vaccine based on the conserved hemagglutinin stalk domain.", MBIO, vol. 1, no. 1, April 2010 (2010-04-01), XP002676044, ISSN: 2150-7511
SRINIVAS S. RAO ET AL: "Comparative Efficacy of Hemagglutinin, Nucleoprotein, and Matrix 2 Protein Gene-Based Vaccination against H5N1 Influenza in Mouse and Ferret", PLOS ONE, vol. 5, no. 3, 1 January 2010 (2010-01-01), pages E9812 - E9812, XP055027360, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0009812
WU F ET AL: "Heterosubtypic protection conferred by combined vaccination with M2e peptide and split influenza vaccine", VACCINE, vol. 27, no. 43, 9 October 2009 (2009-10-09), pages 6095 - 6101, XP026643909, ISSN: 0264-410X, [retrieved on 20081203], DOI: 10.1016/J.VACCINE.2008.11.037
ZHOU DONGMING ET AL: "A universal influenza A vaccine based on adenovirus expressing matrix-2 ectodomain and nucleoprotein protects mice from lethal challenge.", MOLECULAR THERAPY : THE JOURNAL OF THE AMERICAN SOCIETY OF GENE THERAPY, vol. 18, no. 12, December 2010 (2010-12-01), pages 2182 - 2189, XP002676119, ISSN: 1525-0024
KANG S M ET AL: "Novel vaccines against influenza viruses", VIRUS RESEARCH, vol. 162, no. 1, 1 October 2011 (2011-10-01), pages 31 - 38, XP028115824, ISSN: 0168-1702, [retrieved on 20110929], DOI: 10.1016/J.VIRUSRES.2011.09.037
ANNETT HESSEL ET AL: "A Pandemic Influenza H1N1 Live Vaccine Based on Modified Vaccinia Ankara Is Highly Immunogenic and Protects Mice in Active and Passive Immunizations", PLOS ONE, vol. 5, no. 8, 1 January 2010 (2010-01-01), pages E12217 - E12217, XP055003992, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0012217
Attorney, Agent or Firm:
NOLAND, Greta, E. (Gerstein & Borun LLP233 S. Wacker Drive,6300 Willis Towe, Chicago IL, US)
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