RECOMBINANT VIRUS COMBINATION BASED ON AFRICAN SWINE FEVER VIRUS (ASFV) GENES, AND VACCINE PREPARED THEREFROM - ACAD OF MILITARY MEDICAL SCIENCES ACAD OF MILITARY SCIENCES PEOPLES LIBERATION ARMY OF CHINA

Title:

RECOMBINANT VIRUS COMBINATION BASED ON AFRICAN SWINE FEVER VIRUS (ASFV) GENES, AND VACCINE PREPARED THEREFROM

Document Type and Number:

WIPO Patent Application WO/2023/092863

Kind Code:

A1

Abstract:

Disclosed in the present invention are a recombinant virus combination based on African swine fever virus (ASFV) genes, and a vaccine prepared therefrom. Provided in the present invention is an African swine fever virus protein combination, which comprises the following three proteins: MGF 110-5L-6L protein, B119L protein and DP96R protein. The above-mentioned ASFV protein combination also comprises at least one of the following 13 proteins: MGF 110-9L, I329L, MGF 505-5R, B438L, O61R, E199L, M448R, MGF 505-7R, A137R, I177L, I226R, DP71L and K196R. Provided in the present invention are a recombinant virus combination based on ASFV genes, and a vaccine prepared therefrom. After pigs are immunized with the vaccine, susceptible pigs can be protected from natural infection or artificial attack of ASFV. The vaccine is used for the prevention of African swine fever.

Inventors:

HU RONGLIANG (CN)
ZHOU XINTAO (CN)
GUO XIAOPAN (CN)
CHEN TENG (CN)
YUE HUIXIAN (CN)
ZHANG YANYAN (CN)
ZHANG SHOUFENG (CN)
ZHANG FEI (CN)

Application Number:

PCT/CN2022/074457

Publication Date:

June 01, 2023

Filing Date:

January 28, 2022

Export Citation:

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Assignee:

ACAD OF MILITARY MEDICAL SCIENCES ACAD OF MILITARY SCIENCES PEOPLES LIBERATION ARMY OF CHINA (CN)

International Classes:

C07K14/01; A61K39/12; A61P31/20; C12N15/34; C12N15/86

Foreign References:

CN113831394A	2021-12-24
CN113543801A	2021-10-22
CN110269932A	2019-09-24
CN109952310A	2019-06-28

Other References:

NETHERTON CHRISTOPHER L., GOATLEY LYNNETTE C., REIS ANA LUISA, PORTUGAL RAQUEL, NASH RACHEL H., MORGAN SOPHIE B., GAULT LYNDEN, NI: "Identification and Immunogenicity of African Swine Fever Virus Antigens", FRONTIERS IN IMMUNOLOGY, vol. 10, 19 June 2019 (2019-06-19), pages 1 - 21, XP055837179, DOI: 10.3389/fimmu.2019.01318

Attorney, Agent or Firm:

JEEKAI&PARTNERS (CN)

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