Title:
RECOMBINANT VIRUS VECTOR FOR GENE INTRODUCTION IN LYMPHOCYTE
Document Type and Number:
WIPO Patent Application WO/2005/108581
Kind Code:
A1
Abstract:
It is intended to provide a recombinant herpesvirus; a process for producing the same; and a pharmacological composition comprising a recombinant herpesvirus. Further, it is intended to provide a vector comprising a herpesvirus genome gene and a BAC vector sequence; a cell comprising such a vector; a fragment capable of homologous recombination with herpesvirus genome; and a nucleic acid cassette comprising a BAC vector sequence. The objects have been attained by the development of a process for producing a recombinant herpesvirus in which use is made of a BAC vector sequence.
Inventors:
MORI YASUKO (JP)
TADAGAKI KENJIRO (JP)
TAKEMOTO MASAYA (JP)
TAKAHASHI MICHIAKI (JP)
YAMANISHI KOUICHI (JP)
TADAGAKI KENJIRO (JP)
TAKEMOTO MASAYA (JP)
TAKAHASHI MICHIAKI (JP)
YAMANISHI KOUICHI (JP)
Application Number:
PCT/JP2005/008250
Publication Date:
November 17, 2005
Filing Date:
April 28, 2005
Export Citation:
Assignee:
RESEACH FOUNDATION FOR MICROBI (JP)
MORI YASUKO (JP)
TADAGAKI KENJIRO (JP)
TAKEMOTO MASAYA (JP)
TAKAHASHI MICHIAKI (JP)
YAMANISHI KOUICHI (JP)
MORI YASUKO (JP)
TADAGAKI KENJIRO (JP)
TAKEMOTO MASAYA (JP)
TAKAHASHI MICHIAKI (JP)
YAMANISHI KOUICHI (JP)
International Classes:
A61K35/76; A61K35/763; A61K48/00; A61P31/18; C12N1/21; C12N5/10; C12N7/00; C12N7/01; C12N15/09; C12N15/38; C12N15/86; C12N15/869; (IPC1-7): C12N15/38; A61K35/76; A61K48/00; A61P31/18; C12N1/21; C12N7/01
Domestic Patent References:
| WO2003056023A1 | 2003-07-10 | |||
| WO2002081712A2 | 2002-10-17 | |||
| WO2002012288A2 | 2002-02-14 | |||
| WO2000050603A1 | 2000-08-31 |
Other References:
SAEKI K. ET AL: "Herpesvirus DNA Kaihen System no Shinpo.", JAPANESE JOURNAL OF CLINICAL MEDICINE., vol. 58, no. 4, 2000, pages 815 - 821, XP002994283
MESSERLE M ET AL: "Cloning and mutagenesis of a herpesvirus genome as an infectious bacterial artificial chromosome.", PROC NATL ACAD SCI USA., vol. 94, 1997, pages 14759 - 14763, XP002086655
TAKANA M ET AL: "Construction of an excisable bacterial artificial chromosome containing a full-length infectious clone of herpes simplex virus type 1: viruses reconstituted from the clone exhibit wild-type properties in vitro and in vivo.", J VIROL., vol. 77, no. 2, 2003, pages 1382 - 1391, XP002987963
ADLER H ET AL: "Cloning and mutagenesis of the murine gammaherpesvirus 68 genome as an infectious bacterial artificial chromosome.", J VIROL., vol. 74, no. 15, 2000, pages 6964 - 6974, XP002987964
JIA Q ET AL: "Murine gammaherpesvirus 68 open reading frame 31 is required for viral replication.", J VIROL., vol. 78, no. 12, June 2004 (2004-06-01), pages 6610 - 6620, XP002994284
NAIGAKE K ET AL: "Suitotaijo Hoshin Virus no Kumikae Virus no Sakusei.", NIPPON VACCINE GAKKAI GAKUJUTSU SHUKAI PROGRAM., vol. 8, 2004, pages 47, XP002994285
See also references of EP 1743942A4
MESSERLE M ET AL: "Cloning and mutagenesis of a herpesvirus genome as an infectious bacterial artificial chromosome.", PROC NATL ACAD SCI USA., vol. 94, 1997, pages 14759 - 14763, XP002086655
TAKANA M ET AL: "Construction of an excisable bacterial artificial chromosome containing a full-length infectious clone of herpes simplex virus type 1: viruses reconstituted from the clone exhibit wild-type properties in vitro and in vivo.", J VIROL., vol. 77, no. 2, 2003, pages 1382 - 1391, XP002987963
ADLER H ET AL: "Cloning and mutagenesis of the murine gammaherpesvirus 68 genome as an infectious bacterial artificial chromosome.", J VIROL., vol. 74, no. 15, 2000, pages 6964 - 6974, XP002987964
JIA Q ET AL: "Murine gammaherpesvirus 68 open reading frame 31 is required for viral replication.", J VIROL., vol. 78, no. 12, June 2004 (2004-06-01), pages 6610 - 6620, XP002994284
NAIGAKE K ET AL: "Suitotaijo Hoshin Virus no Kumikae Virus no Sakusei.", NIPPON VACCINE GAKKAI GAKUJUTSU SHUKAI PROGRAM., vol. 8, 2004, pages 47, XP002994285
See also references of EP 1743942A4
Attorney, Agent or Firm:
Yamamoto, Shusaku (Crystal Tower 2-27, Shiromi 1-chome, Chuo-ku, Osaka-sh, Osaka 15, JP)
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