Title:
REDIRECTED BIOENERGETICS IN RECOMBINANT CELLULOLYTIC CLOSTRIDIUM MICROORGANISMS
Document Type and Number:
WIPO Patent Application WO/2011/137401
Kind Code:
A3
Abstract:
Compositions and methods are provided for redirecting metabolic solventogenesis pathways to enhance the product yield from fermentation of biomass. Clostridium microorganism pathways are modified to extend the growth phase and prevent inhibition of acetaldehyde while bypassing the synthesis of acetyl CoA.
Inventors:
GRAY KEVIN (US)
O'MULLAN PATRICK (US)
O'MULLAN PATRICK (US)
Application Number:
PCT/US2011/034687
Publication Date:
March 15, 2012
Filing Date:
April 29, 2011
Export Citation:
Assignee:
QTEROS INC (US)
GRAY KEVIN (US)
O'MULLAN PATRICK (US)
GRAY KEVIN (US)
O'MULLAN PATRICK (US)
International Classes:
C12N1/21; C12N15/52; C12P7/06; C12R1/145
Foreign References:
| US5487989A | 1996-01-30 | |||
| US20090275097A1 | 2009-11-05 |
Other References:
GUEDON, E. ET AL.: "Improvement of cellulolytic properties of Clostridium cellulolyticum by metabolic engineering.", APPL. ENVIRON. MICROBIOL., vol. 68, no. 1, 2002, pages 53 - 58
NICHOLS, N. N. ET AL.: "Engineering lactic acid bacteria with pyruvate decarboxylase and alcohol dehydrogenase genes for ethanol production from Zymomonas mobilis.", J. IND. MICROBIOL. BIOTECHNOL., vol. 30, 2003, pages 315 - 321
SHAW, A. J. ET AL.: "Metabolic engineering of a thermophilic bacterium to produce ethanol at high yield.", PROC. NATL. ACAD. SCI., vol. 105, no. 37, 16 September 2008 (2008-09-16), pages 13769 - 13774
NICHOLS, N. N. ET AL.: "Engineering lactic acid bacteria with pyruvate decarboxylase and alcohol dehydrogenase genes for ethanol production from Zymomonas mobilis.", J. IND. MICROBIOL. BIOTECHNOL., vol. 30, 2003, pages 315 - 321
SHAW, A. J. ET AL.: "Metabolic engineering of a thermophilic bacterium to produce ethanol at high yield.", PROC. NATL. ACAD. SCI., vol. 105, no. 37, 16 September 2008 (2008-09-16), pages 13769 - 13774
Attorney, Agent or Firm:
VAN GOOR, David et al. (650 Page Mill RoadPalo Alto, CA, US)
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