Title:
REDUCIBLE DEGRADABLE HYPERBRANCHED-POLYMER NANOMICELLE AND METHOD FOR PREPARATION THEREOF AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2017/107486
Kind Code:
A1
Abstract:
Provided are a reducible degradable hyperbranched-polymer nanomicelle and a method for preparation thereof and an application thereof. Cystamine and polyethylene glycol diglycidyl ether are polymerized by means of a nucleophilic addition mechanism; in one step, a hyperbranched polymer alternatingly arising from cystamine and polyethylene glycol structural units is synthesized and obtained; then, a hyperbranched nanomicelle is formed by means of self-assembly during the process of dialysis. The hyperbranched-polymer chain segments contain both tertiary aminos and disulfide bond structural units and have pH- and reduction responsiveness, and the hyperbranched three-dimensional cavity structure imparts a drug-carrying ability to the nanomicelle.
Inventors:
NI CAIHUA (CN)
ZHOU YAMIN (CN)
ZHANG LIPING (CN)
SHI GANG (CN)
ZHOU YAMIN (CN)
ZHANG LIPING (CN)
SHI GANG (CN)
Application Number:
PCT/CN2016/092187
Publication Date:
June 29, 2017
Filing Date:
July 29, 2016
Export Citation:
Assignee:
UNIV JIANGNAN (CN)
International Classes:
A61K47/34; A61P35/00; C08G83/00
Foreign References:
| CN105395483A | 2016-03-16 | |||
| CN104004196A | 2014-08-27 |
Other References:
YANG, SUFANG ET AL.: "Application of Hyperbranched Copolymers to Drug Carriers", CHINESE JOURNAL OF PHARMACEUTICALS, vol. 44, no. 11, 30 November 2013 (2013-11-30), pages 1160 - 1165, ISSN: 1001-8255
ZHANG, YI ET AL.: "Functionally Modified Hyperbranched Polyglycerols for Drug Delivery", CHINESE JOURNAL OF APPUED CHEMISTRY, vol. 32, no. 4, 30 April 2015 (2015-04-30), pages 367 - 378, ISSN: 1000-0518
ZHANG, YI ET AL.: "Functionally Modified Hyperbranched Polyglycerols for Drug Delivery", CHINESE JOURNAL OF APPUED CHEMISTRY, vol. 32, no. 4, 30 April 2015 (2015-04-30), pages 367 - 378, ISSN: 1000-0518
Attorney, Agent or Firm:
CENTRAL SOUTH WELL INTELLECTUAL PROPERTY OFFICE (CN)
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