Title:
REDUCING BACKGROUND FLUORESCENCE IN MEMS MATERIALS BY LOW ENERGY ION BEAM TREATMENT
Document Type and Number:
WIPO Patent Application WO/2014/066905
Kind Code:
A3
Abstract:
Methods for fabricating materials useful for optical detection in microfluidic and nanofluidic devices, such as those used in nanopore-based nucleic acid sequencing are described herein. In certain variations, a method of reducing background fluorescence in a MEMS material may include the step of treating a surface of the MEMS material with a low energy ion beam.
Inventors:
HUBER MARTIN (US)
CLANCY BASON E (US)
HALL ADAM R (US)
CLANCY BASON E (US)
HALL ADAM R (US)
Application Number:
PCT/US2013/067126
Publication Date:
July 16, 2015
Filing Date:
October 28, 2013
Export Citation:
Assignee:
QUANTAPORE INC (US)
UNIV NORTH CAROLINA AT GREENSBORO (US)
UNIV NORTH CAROLINA AT GREENSBORO (US)
International Classes:
G01N21/64; B01L3/00; B05D3/00; G01N21/66
Foreign References:
| US20040137158A1 | 2004-07-15 | |||
| US20020034762A1 | 2002-03-21 | |||
| US20090314939A1 | 2009-12-24 | |||
| US20020025529A1 | 2002-02-28 | |||
| US20040002089A1 | 2004-01-01 | |||
| US20090148348A1 | 2009-06-11 |
Other References:
GALLA ET AL.: "Microfluidic carbon-blackened polydimethylsiloxane device with reduced ultra violet background fluorescence for simultaneous two-color ultra violet/visible- laser induced fluorescence detection in single cell analysis", BIOMICROFLUIDICS, vol. 6, 12 January 2012 (2012-01-12), pages 014104
HSIEH ET AL.: "Effective Enhancement of Fluorescence Detection Efficiency in Protein Microarray Assays: Application of a Highly Fluorinated Organosilane as the Blocking Agent on the Background Surface by a Facile Vapor-Phase Deposition Process", ANAL. CHEM., vol. 81, 2009, pages 7908 - 7916
LEE ET AL.: "High aspect ratio polymer microstructures and cantilevers for bioMEMS using low energy ion beam and photolithography", SENSORS AND ACTUATORS A, vol. 71, 1998, pages 144 - 149
LU ET AL.: "PARYLENE BACKGROUND FLUORESCENCE STUDY FOR BIOMEMS APPLICATIONS", TRANSDUCERS, 21 June 2009 (2009-06-21), DENVER, CO, USA, pages 178
HSIEH ET AL.: "Effective Enhancement of Fluorescence Detection Efficiency in Protein Microarray Assays: Application of a Highly Fluorinated Organosilane as the Blocking Agent on the Background Surface by a Facile Vapor-Phase Deposition Process", ANAL. CHEM., vol. 81, 2009, pages 7908 - 7916
LEE ET AL.: "High aspect ratio polymer microstructures and cantilevers for bioMEMS using low energy ion beam and photolithography", SENSORS AND ACTUATORS A, vol. 71, 1998, pages 144 - 149
LU ET AL.: "PARYLENE BACKGROUND FLUORESCENCE STUDY FOR BIOMEMS APPLICATIONS", TRANSDUCERS, 21 June 2009 (2009-06-21), DENVER, CO, USA, pages 178
Attorney, Agent or Firm:
GIOVANNETTI, Steven M. et al. (2400 Geng Road Suite 12, Palo Alto California, US)
Download PDF:
Previous Patent: PATIENT POSITIONING DEVICE FOR PRONE BREAST SIMULATION AND RADIATION THERAPY
Next Patent: NIR IMAGE GUIDED TARGETING
Next Patent: NIR IMAGE GUIDED TARGETING