Title:
REDUCING SMOOTH MUSCLE CONTRACTILE RESPONSE INDUCED BY INFLAMMATORY CONSTRICTORS
Document Type and Number:
WIPO Patent Application WO/2018/112814
Kind Code:
A1
Abstract:
The present disclosure provides a method of reducing the contractile response of smooth muscle cells that is induced by one or more inflammatory constrictors by TMEM16A inhibitors. Embodiments herein include contacting target cells with an effective amount of an agent that inhibits activation or signaling of TMEM16A.
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Inventors:
ZHU MINSHENG (CN)
WANG PEI (CN)
ZHAO WEI (CN)
WANG PEI (CN)
ZHAO WEI (CN)
Application Number:
PCT/CN2016/111402
Publication Date:
June 28, 2018
Filing Date:
December 22, 2016
Export Citation:
Assignee:
UNIV NANJING (CN)
International Classes:
A61K39/395; A61K31/44; A61P9/08; A61P11/08
Other References:
LEBLANC N. ET AL.: "Molecular and functional significance of Ca2+-activated CI- channels in pulmonary arterial smooth muscle", PULMONARY CIRCULATION, vol. 5, no. 2, 15 April 2015 (2015-04-15), pages 244 - 268, XP055509229
DANIELSSON J. ET AL.: "Antagonists of the TMEM16A Calcium-Activated Chloride Channel Modulate Airway Smooth Muscle Tone and Intracellular Calcium", ANESTHESIOLOGY, vol. 123, no. 3, 30 September 2015 (2015-09-30), pages 569 - 581, XP055509238
FEN HUANG ET AL.: "Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction", ANESTHESIOLOGY, vol. 109, no. 40, 2 October 2012 (2012-10-02), pages 16354 - 16359, XP055509245
DANIELSSON J. ET AL.: "Antagonists of the TMEM16A Calcium-Activated Chloride Channel Modulate Airway Smooth Muscle Tone and Intracellular Calcium", ANESTHESIOLOGY, vol. 123, no. 3, 30 September 2015 (2015-09-30), pages 569 - 581, XP055509238
FEN HUANG ET AL.: "Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction", ANESTHESIOLOGY, vol. 109, no. 40, 2 October 2012 (2012-10-02), pages 16354 - 16359, XP055509245
Attorney, Agent or Firm:
NANJING ZHISHI LAW FIRM OF INTELLECTUAL PROPERTY (CN)
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