Title:
REDUCTION OF ER-MAM-LOCALIZED APP-C99 AND METHODS OF TREATING ALZHEIMER'S DISEASE
Document Type and Number:
WIPO Patent Application WO/2017/044807
Kind Code:
A3
Abstract:
The invention provides for methods for treating Alzheimer's Disease in a subject by reducing ER-MAM localized APP-C99.
Inventors:
SCHON ERIC A (US)
AREA-GOMEZ ESTELA (US)
AREA-GOMEZ ESTELA (US)
Application Number:
PCT/US2016/051046
Publication Date:
May 26, 2017
Filing Date:
September 09, 2016
Export Citation:
Assignee:
UNIV COLUMBIA (US)
International Classes:
C12Q1/37; A61P25/00; C07K14/00; C12Q1/60
Foreign References:
| US20140044757A1 | 2014-02-13 |
Other References:
JEMBREK ET AL.: "Ceramides in Alzheimer's Disease: Key Mediators of Neuronal Apoptosis Induced by Oxidative Stress and Abeta Accumulation.", OXID MED CELL LONGEV, vol. 2015, 24 May 2015 (2015-05-24), pages 1 - 17, XP055383768
SCHON ET AL.: "Mitochondria-associated ER membranes in Alzheimer disease.", MOL CELL NEUROSCI, vol. 55, July 2013 (2013-07-01), pages 26 - 36, XP055383772
THATHIAH ET AL.: "The orphan G protein-coupled receptor 3 modulates amyloid-beta peptide generation in neurons.", SCIENCE, vol. 323, no. 5916, 13 February 2009 (2009-02-13), pages 946 - 951, XP002591660
DIMITROV ET AL.: "Alzheimers disease mutations in APP but not beta-secretase modulators affect opsilon-cleavage-dependent AICD production.", NAT COMM, vol. 4, no. 22-16, 2 August 2013 (2013-08-02), pages 1 - 10, XP055383777
SCHON ET AL.: "Mitochondria-associated ER membranes in Alzheimer disease.", MOL CELL NEUROSCI, vol. 55, July 2013 (2013-07-01), pages 26 - 36, XP055383772
THATHIAH ET AL.: "The orphan G protein-coupled receptor 3 modulates amyloid-beta peptide generation in neurons.", SCIENCE, vol. 323, no. 5916, 13 February 2009 (2009-02-13), pages 946 - 951, XP002591660
DIMITROV ET AL.: "Alzheimers disease mutations in APP but not beta-secretase modulators affect opsilon-cleavage-dependent AICD production.", NAT COMM, vol. 4, no. 22-16, 2 August 2013 (2013-08-02), pages 1 - 10, XP055383777
Attorney, Agent or Firm:
SUPERKO, Colleen et al. (US)
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