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Patent Searching and Data


Title:
REELIN COMPOSITIONS FOR TREATMENT OF NEUROLOGICAL DISORDERS
Document Type and Number:
WIPO Patent Application WO/2018/027037
Kind Code:
A3
Abstract:
Changes in Reelin levels as well as Reelin signaling alter cognitive function. This can be accomplished by administering a therapeutically effective amount of a repeat fragment of Reelin, or a construct formed from fragment repeats of Reelin to a patient or subject. Changes to Reelin levels can be used to treat various neurodegenerative diseases, neuronal insults, or stroke, such as fragile X syndrome, William's syndrome, Rett syndrome, Down's syndrome, Angelman syndrome, autism, ischemia, hypoxia, Alzheimer's disease, and schizophrenia. Reelin can also be used to alter dendritic spine density, diminished long-term potentiation, and diminished synaptic plasticity and associative learning deficits. Constructs formed from repeat region 3 of full length Reelin and repeat region 5 of full length Reelin, or repeat region 3 of full length Reelin and repeat region 6 of full length Reelin have been found particularly useful.

Inventors:
WEEBER EDWIN J (US)
Application Number:
PCT/US2017/045307
Publication Date:
March 01, 2018
Filing Date:
August 03, 2017
Export Citation:
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Assignee:
UNIV SOUTH FLORIDA (US)
WEEBER EDWIN J (US)
International Classes:
A61K38/17; A61K38/48; A61K39/395; A61P25/00; A61P25/18; A61P25/28
Foreign References:
US9241975B22016-01-26
US6323177B12001-11-27
Other References:
SCHMID ET AL.: "Reelin, integrin and DAB1 interactions during embryonic cerebral cortical development", CEREB CORTEX, vol. 15, no. 10, 2005, pages 1632 - 1636, XP055470287
NOGI ET AL.: "Structure of a signaling-competent reelin fragment revealed by X-ray crystallography and electron tomography", EMBO J., vol. 25, no. 15, 2006, pages 3675 - 3683, XP055470289
RANAIVOSON ET AL.: "Structural Insights into Reelin Function: Present and Future", FRONT CELL NEUROSCI, vol. 10, 27 May 2016 (2016-05-27), pages 1 - 8, XP055470296
ORCINHA ET AL.: "Seizure-Induced Motility of Differentiated Dentate Granule Cells Is Prevented by the Central Reelin Fragment", FRONT CELL NEUROSCI., vol. 10, 28 July 2016 (2016-07-28), pages 1 - 13, XP055470298
Attorney, Agent or Firm:
VARKONYI, Robert, J. (US)
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