Title:
REELIN DECOMPOSITION USING ADAMTS-3
Document Type and Number:
WIPO Patent Application WO/2014/027668
Kind Code:
A1
Abstract:
[Problem] To identify an enzyme that decomposes active reelin into an inactive form and to provide an effective treatment and research means for diseases such as Alzheimer's disease based on active reelin decrease using this enzyme and/or a gene thereof. [Solution] ADAMTS-3, which is used to decompose active reelin into inactive reelin, and functional derivatives thereof. A method for using ADAMTS-3 that uses ADAMTS-3 or a functional derivative thereof for treatment or research relating to the physiologic functions of reelin or the promotion or suppression thereof.
Inventors:
HATTORI MITSUHARU (JP)
KOHNO TAKAO (JP)
HISANAGA ARISA (JP)
KOIE MARI (JP)
SUZUKI KENTA (JP)
KOHNO TAKAO (JP)
HISANAGA ARISA (JP)
KOIE MARI (JP)
SUZUKI KENTA (JP)
Application Number:
PCT/JP2013/071911
Publication Date:
February 20, 2014
Filing Date:
August 14, 2013
Export Citation:
Assignee:
PUBLIC UNIV CORP NAGOYA CITY UNIV (JP)
International Classes:
C12N9/64; A61K31/7088; A61K38/46; A61K48/00; A61P25/28; A61P43/00; C12Q1/37; G01N33/15; G01N33/50; C07K14/47; C12N15/113
Other References:
FERNANDES, R. J. ET AL.: "Procollagen II Amino Propeptide Processing by ADAMTS-3 INSIGHTS ON DERMATOSPARAXIS", J. BIOL. CHEM., vol. 276, no. 34, 2001, pages 31502 - 31509
HISANAGA, A. ET AL.: "A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS-4) cleaves Reelin in an isoform- dependent manner", FEBS LETT., vol. 586, 21 September 2012 (2012-09-21), pages 3349 - 3353
ARISA HISANAGA ET AL.: "Mechanism of specific proteolytic cleavage of Reelin", DAI 11 KAI JISEDAI O NINAU WAKATE PHARMA BIOFORUM 2012 KOEN YOSHISHU, September 2012 (2012-09-01), pages 34
HISANAGA, A. ET AL.: "A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS-4) cleaves Reelin in an isoform- dependent manner", FEBS LETT., vol. 586, 21 September 2012 (2012-09-21), pages 3349 - 3353
ARISA HISANAGA ET AL.: "Mechanism of specific proteolytic cleavage of Reelin", DAI 11 KAI JISEDAI O NINAU WAKATE PHARMA BIOFORUM 2012 KOEN YOSHISHU, September 2012 (2012-09-01), pages 34
Attorney, Agent or Firm:
KITAGAWA Osamu et al. (JP)
Kitagawa 治 (JP)
Kitagawa 治 (JP)
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