Title:
REFRACTORY NEUROLOGICAL DISORDER TREATMENT COMPOSITION AND METHOD FOR PRODUCING SAME
Document Type and Number:
WIPO Patent Application WO/2023/195432
Kind Code:
A1
Abstract:
By providing are a refractory neurological disorder treatment composition, and a method for producing the same, it is possible to treat amyotrophic lateral sclerosis (ALS) and Alzheimer's disease. The refractory neurological disorder treatment composition is characterized by containing a culture supernatant obtained by culturing deciduous tooth pulp stem cells in a serum-free medium under supersonic irradiation. Also provided is an amyotrophic lateral sclerosis (ALS) treatment drug and an Alzheimer's disease treatment drug characterized by containing said refractory neurological disorder treatment composition. The method for producing a refractory neurological disorder treatment composition is characterized by obtaining culture supernatant by culturing deciduous tooth pulp stem cells in a serum-free medium under supersonic irradiation, and using the culture supernatant to make said composition.
Inventors:
UEDA MINORU (JP)
Application Number:
PCT/JP2023/013671
Publication Date:
October 12, 2023
Filing Date:
March 31, 2023
Export Citation:
Assignee:
SAISEIKEN CO LTD (JP)
International Classes:
A61K35/32; A61P21/00; A61P25/28; C12N5/0797
Domestic Patent References:
| WO2011118795A1 | 2011-09-29 |
Foreign References:
| KR20090008784A | 2009-01-22 | |||
| JP2005334456A | 2005-12-08 | |||
| JP2022502033A | 2022-01-11 | |||
| JP2022502032A | 2022-01-11 |
Other References:
UEDA, MINORU: "Organ regeneration using stem cell culture medium", JOURNAL OF THE SOCIETY FOR JAPANESE BLOOD PROGRAMME, JAPAN SOCIETY FOR HEMATOLOGY, JP, vol. 36, no. 4, 1 January 2014 (2014-01-01), JP , pages 841 - 844, XP009550178, ISSN: 0917-7833
MITA, TSUNEYUKI ET AL.: "F-1-4: Possibility of treating Alzheimer's dementia using deciduous dental pulp stem cell-derived culture supernatant", REGENERATIVE MEDICINE, JAPANESE SOCIETY FOR REGENERATIVE MEDICINE, JP, vol. 12, no. Suppl., 1 January 2013 (2013-01-01), JP , pages 266, XP009550180, ISSN: 1347-7919
GAO QIANHUA, WALMSLEY A. DAMIEN, COOPER PAUL R., SCHEVEN BEN A.: "Ultrasound Stimulation of Different Dental Stem Cell Populations: Role of Mitogen-activated Protein Kinase Signaling", JOURNAL OF ENDODONTICS, ELSEVIER, AMSTERDAM, NL, vol. 42, no. 3, 1 March 2016 (2016-03-01), AMSTERDAM, NL , pages 425 - 431, XP093097196, ISSN: 0099-2399, DOI: 10.1016/j.joen.2015.12.019
DRAGO DENISE; COSSETTI CHIARA; IRACI NUNZIO; GAUDE EDOARDO; MUSCO GIOVANNA; BACHI ANGELA; PLUCHINO STEFANO: "The stem cell secretome and its role in brain repair", BIOCHIMIE, MASSON, PARIS, FR, vol. 95, no. 12, 1 July 2013 (2013-07-01), FR , pages 2271 - 2285, XP028768030, ISSN: 0300-9084, DOI: 10.1016/j.biochi.2013.06.020
CHIAKI SHIMOJIMA, ET AL.: "Conditioned Medium from the Stem Cells of Human Exfoliated Deciduous Teeth Ameliorates Experimental Autoimmune Encephalomyelitis", THE JOURNAL OF IMMUNOLOGY, WILLIAMS & WILKINS CO., US, vol. 196, no. 10, 15 May 2016 (2016-05-15), US , pages 4164 - 4171, XP055603827, ISSN: 0022-1767, DOI: 10.4049/jimmunol.1501457
MITA, TSUNEYUKI ET AL.: "F-1-4: Possibility of treating Alzheimer's dementia using deciduous dental pulp stem cell-derived culture supernatant", REGENERATIVE MEDICINE, JAPANESE SOCIETY FOR REGENERATIVE MEDICINE, JP, vol. 12, no. Suppl., 1 January 2013 (2013-01-01), JP , pages 266, XP009550180, ISSN: 1347-7919
GAO QIANHUA, WALMSLEY A. DAMIEN, COOPER PAUL R., SCHEVEN BEN A.: "Ultrasound Stimulation of Different Dental Stem Cell Populations: Role of Mitogen-activated Protein Kinase Signaling", JOURNAL OF ENDODONTICS, ELSEVIER, AMSTERDAM, NL, vol. 42, no. 3, 1 March 2016 (2016-03-01), AMSTERDAM, NL , pages 425 - 431, XP093097196, ISSN: 0099-2399, DOI: 10.1016/j.joen.2015.12.019
DRAGO DENISE; COSSETTI CHIARA; IRACI NUNZIO; GAUDE EDOARDO; MUSCO GIOVANNA; BACHI ANGELA; PLUCHINO STEFANO: "The stem cell secretome and its role in brain repair", BIOCHIMIE, MASSON, PARIS, FR, vol. 95, no. 12, 1 July 2013 (2013-07-01), FR , pages 2271 - 2285, XP028768030, ISSN: 0300-9084, DOI: 10.1016/j.biochi.2013.06.020
CHIAKI SHIMOJIMA, ET AL.: "Conditioned Medium from the Stem Cells of Human Exfoliated Deciduous Teeth Ameliorates Experimental Autoimmune Encephalomyelitis", THE JOURNAL OF IMMUNOLOGY, WILLIAMS & WILKINS CO., US, vol. 196, no. 10, 15 May 2016 (2016-05-15), US , pages 4164 - 4171, XP055603827, ISSN: 0022-1767, DOI: 10.4049/jimmunol.1501457
Attorney, Agent or Firm:
HAGIMORI Manabu (JP)
Download PDF:
Previous Patent: SEAT MOUNTING STRUCTURE
Next Patent: INK SET, IMAGE-RECORDING METHOD, AND OBJECT WITH RECORDED IMAGE
Next Patent: INK SET, IMAGE-RECORDING METHOD, AND OBJECT WITH RECORDED IMAGE