Title:
REGENERATION OF MAMMALIAN TISSUES USING SYNTHETIC IMMODULINS
Document Type and Number:
WIPO Patent Application WO/2022/192042
Kind Code:
A3
Abstract:
Methods and compositions involving synthetic immodulin peptides and helper molecules. The peptides exhibit new and surprising biological activities, such as co-stimulation of macrophage and myogenic cell differentiation markers. Methods are provided by which peptide is contacted with one or more myeloid precursor cell populations, thereby increasing the abundance of CD169+, CCL22+, Clec4A, Clec9a+, and Clec12a+ monocyte lineages which play important roles in cross presentation, post-apoptotic clearance, autoimmunity, and programmatic tissue regeneration, notably in contexts of tissue stress, insult and degeneration. The disclosed methods and compositions enable concurrent regeneration of diverse cellular elements in tissue where collaborating myeloid and non-myeloid lineages are located together in a living tissue following the contacting steps. Furthermore, the peptides of the invention can be delivered with inherently specific in vivo targeting, achieved through complexation to holotransferrin and/or size-specific glycosaminoglycans (e.g. high-molecular- weight hyaluronan) so as to discriminate between target environments in vivo or ex vivo.
Inventors:
MASCARENHAS DESMOND (US)
Application Number:
PCT/US2022/018449
Publication Date:
December 22, 2022
Filing Date:
March 02, 2022
Export Citation:
Assignee:
MASCARENHAS DESMOND (US)
International Classes:
A61K35/12; A61K38/00; A61P37/02
Domestic Patent References:
| WO2022192042A2 | 2022-09-15 |
Foreign References:
| US20200017584A1 | 2020-01-16 | |||
| US20120252722A1 | 2012-10-04 | |||
| US20070128113A1 | 2007-06-07 | |||
| US20140199349A1 | 2014-07-17 | |||
| US20110212079A1 | 2011-09-01 | |||
| CN105944108A | 2016-09-21 | |||
| US20080108101A1 | 2008-05-08 |
Other References:
MASCARENHAS DESMOND D., RAVIKUMAR PUJA, AMENTO EDWARD P.: "Covalent modification of nephrilin peptide with valproic acid increases its efficacy as a therapeutic in burn trauma", BURNS OPEN, vol. 4, no. 3, July 2020 (2020-07-01), pages 85 - 89, XP093017145
ZHANG HUIJUAN, HOU LIN, JIAO XIAOJING, JI YANDAN, ZHU XIALI, ZHANG ZHENZHONG: "Transferrin-mediated fullerenes nanoparticles as Fe 2+ -dependent drug vehicles for synergistic anti-tumor efficacy", BIOMATERIALS, ELSEVIER, vol. 37, 1 January 2015 (2015-01-01), AMSTERDAM, NL , pages 353 - 366, XP009542065, ISSN: 0142-9612, DOI: 10.1016/j.biomaterials.2014.10.031
HUTADILOK ET AL.: "Binding of haptoglobin, inter-alpha-trypsin inhibitor, and alpha 1 proteinase inhibitor to synovial fluid hyaluronate and the influence of these proteins on its degradation by oxygen derived free radicals", ANNALS OF THE RHEUMATIC DISEASES, vol. 47, no. 5, May 1988 (1988-05-01), pages 377 - 85, XP001034235
ZHANG HUIJUAN, HOU LIN, JIAO XIAOJING, JI YANDAN, ZHU XIALI, ZHANG ZHENZHONG: "Transferrin-mediated fullerenes nanoparticles as Fe 2+ -dependent drug vehicles for synergistic anti-tumor efficacy", BIOMATERIALS, ELSEVIER, vol. 37, 1 January 2015 (2015-01-01), AMSTERDAM, NL , pages 353 - 366, XP009542065, ISSN: 0142-9612, DOI: 10.1016/j.biomaterials.2014.10.031
HUTADILOK ET AL.: "Binding of haptoglobin, inter-alpha-trypsin inhibitor, and alpha 1 proteinase inhibitor to synovial fluid hyaluronate and the influence of these proteins on its degradation by oxygen derived free radicals", ANNALS OF THE RHEUMATIC DISEASES, vol. 47, no. 5, May 1988 (1988-05-01), pages 377 - 85, XP001034235
Download PDF:
Previous Patent: MULTI-ZONE SEMICONDUCTOR SUBSTRATE SUPPORTS
Next Patent: THERMALLY CONDUCTIVE NANOMATERIAL COATINGS ON FLEXIBLE FOAM OR FABRICS
Next Patent: THERMALLY CONDUCTIVE NANOMATERIAL COATINGS ON FLEXIBLE FOAM OR FABRICS