Title:
REGULATION OF CGMP-SPECIFIC PHOSPHODIESTERASE 9A
Document Type and Number:
WIPO Patent Application WO2003041725
Kind Code:
A3
Abstract:
The invention relates to the use of PDE9A inhibitors for producing a pharmaceutical for the treatment and/or prophylaxis of coronary heart diseases, especially stable and unstable angina pectoris, acute myocardial infarction, the prophylaxis of myocardial infarction, sudden cardiac death, heart failure, and hypertension, peripheral circulatory disturbances and arteriosclerosis.
Inventors:
WUNDER FRANK (DE)
ELLINGHAUS PETER (DE)
ELLINGHAUS PETER (DE)
Application Number:
PCT/EP2002/012550
Publication Date:
March 18, 2004
Filing Date:
November 11, 2002
Export Citation:
Assignee:
BAYER HEALTHCARE AG (DE)
WUNDER FRANK (DE)
ELLINGHAUS PETER (DE)
WUNDER FRANK (DE)
ELLINGHAUS PETER (DE)
International Classes:
C12Q1/68; A61K38/46; A61K45/00; A61P9/00; A61P9/04; A61P9/08; A61P9/10; A61P9/12; A61P43/00; (IPC1-7): A61K35/00; A61P9/00
Domestic Patent References:
| WO1999029873A1 | 1999-06-17 |
Foreign References:
| DE4211239A1 | 1993-10-07 |
Other References:
FISHER D A ET AL: "Isolation and characterization of PDE9A, a novel human cGMP-specific phosphodiesterase", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 273, no. 25, 19 June 1998 (1998-06-19), pages 15559 - 15564, XP002091363, ISSN: 0021-9258
STOCLET J-C ET AL: "CYCLIC NUCLEOTIDE PHOSPHODIESTERASES AS THERAPEUTIC TARGETS IN CARDIOVASCULAR DISEASES", EXPERT OPINION ON INVESTIGATIONAL DRUGS, ASHLEY PUBLICATIONS LTD., LONDON, GB, vol. 4, no. 11, November 1995 (1995-11-01), pages 1081 - 1100, XP000995813, ISSN: 1354-3784
SODERLING S H ET AL: "Identification and characterization of a novel family of cyclic nucleotide phosphoiesterase", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 273, no. 25, 19 June 1998 (1998-06-19), pages 15553 - 15558, XP002127167, ISSN: 0021-9258
VEMULAPALLI S ET AL: "ANTIPLATELET AND ANTIPROLIFERATIVE EFFECTS OF SCH 51866, A NOVEL TYPE 1 AND TYPE 5 PHOSPHODIESTERASE INHIBITOR", JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, NEW YORK, NY, US, vol. 28, no. 6, December 1996 (1996-12-01), pages 862 - 869, XP000998260, ISSN: 0160-2446
SYBERTZ E ET AL: "Inhibitors of PDE1 and PDE5 cGMP phospodiesterases: patents and therapeutic potential", EXPERT OPINION ON THERAPEUTIC PATENTS, ASHLEY PUBLICATIONS, GB, vol. 7, no. 6, 1997, pages 631 - 639, XP002178692, ISSN: 1354-3776
TRAVERSE J H ET AL: "Cyclic nucleotide phosphodiesterase type 5 activity limits blood flow to hypoperfused myocardium during exercise.", CIRCULATION. UNITED STATES 12 DEC 2000, vol. 102, no. 24, 12 December 2000 (2000-12-12), pages 2997 - 3002, XP002252803, ISSN: 1524-4539
GUIPPONI M ET AL: "IDENTIFICATION AND CHARACTERIZATON OF A NOVEL CYCLIC NUCLEOTIDE PHOSPHODIESTERASE GENE (PDE9A) THAT MAPS TO 21Q22.3: ALTERNATIVE SPLICING OF MRNA TRANSCRIPTS, GENOMIC STRUCTURE AND SEQUENCE", EUROPEAN JOURNAL OF HUMAN GENETICS, KARGER, BASEL, CH, vol. 103, no. 4, October 1998 (1998-10-01), pages 386 - 392, XP001000997, ISSN: 1018-4813
FRANCIS S H ET AL: "CYCLIC NUCLEOTIDE PHOSPHODIESTERASES: RELATING STRUCTURE AND FUNCTION", PROGRESS IN NUCLEIC ACID RESEARCH AND MOLECULAR BIOLOGY, ACADEMIC PRESS, US, vol. 65, 2000, pages 1 - 52, XP000993322, ISSN: 0079-6603
BEAVO J A: "CYCLIC NUCLEOTIDE PHOSPHODIESTERASES: FUNCTIONAL IMPLICATIONS OF MULTIPLE ISOFORMS", PHYSIOLOGICAL REVIEWS, AMERICAN PHYSIOLOGICAL SOCIETY, US, vol. 75, no. 4, 1 October 1995 (1995-10-01), pages 725 - 748, XP002034532, ISSN: 0031-9333
STOCLET J-C ET AL: "CYCLIC NUCLEOTIDE PHOSPHODIESTERASES AS THERAPEUTIC TARGETS IN CARDIOVASCULAR DISEASES", EXPERT OPINION ON INVESTIGATIONAL DRUGS, ASHLEY PUBLICATIONS LTD., LONDON, GB, vol. 4, no. 11, November 1995 (1995-11-01), pages 1081 - 1100, XP000995813, ISSN: 1354-3784
SODERLING S H ET AL: "Identification and characterization of a novel family of cyclic nucleotide phosphoiesterase", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 273, no. 25, 19 June 1998 (1998-06-19), pages 15553 - 15558, XP002127167, ISSN: 0021-9258
VEMULAPALLI S ET AL: "ANTIPLATELET AND ANTIPROLIFERATIVE EFFECTS OF SCH 51866, A NOVEL TYPE 1 AND TYPE 5 PHOSPHODIESTERASE INHIBITOR", JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, NEW YORK, NY, US, vol. 28, no. 6, December 1996 (1996-12-01), pages 862 - 869, XP000998260, ISSN: 0160-2446
SYBERTZ E ET AL: "Inhibitors of PDE1 and PDE5 cGMP phospodiesterases: patents and therapeutic potential", EXPERT OPINION ON THERAPEUTIC PATENTS, ASHLEY PUBLICATIONS, GB, vol. 7, no. 6, 1997, pages 631 - 639, XP002178692, ISSN: 1354-3776
TRAVERSE J H ET AL: "Cyclic nucleotide phosphodiesterase type 5 activity limits blood flow to hypoperfused myocardium during exercise.", CIRCULATION. UNITED STATES 12 DEC 2000, vol. 102, no. 24, 12 December 2000 (2000-12-12), pages 2997 - 3002, XP002252803, ISSN: 1524-4539
GUIPPONI M ET AL: "IDENTIFICATION AND CHARACTERIZATON OF A NOVEL CYCLIC NUCLEOTIDE PHOSPHODIESTERASE GENE (PDE9A) THAT MAPS TO 21Q22.3: ALTERNATIVE SPLICING OF MRNA TRANSCRIPTS, GENOMIC STRUCTURE AND SEQUENCE", EUROPEAN JOURNAL OF HUMAN GENETICS, KARGER, BASEL, CH, vol. 103, no. 4, October 1998 (1998-10-01), pages 386 - 392, XP001000997, ISSN: 1018-4813
FRANCIS S H ET AL: "CYCLIC NUCLEOTIDE PHOSPHODIESTERASES: RELATING STRUCTURE AND FUNCTION", PROGRESS IN NUCLEIC ACID RESEARCH AND MOLECULAR BIOLOGY, ACADEMIC PRESS, US, vol. 65, 2000, pages 1 - 52, XP000993322, ISSN: 0079-6603
BEAVO J A: "CYCLIC NUCLEOTIDE PHOSPHODIESTERASES: FUNCTIONAL IMPLICATIONS OF MULTIPLE ISOFORMS", PHYSIOLOGICAL REVIEWS, AMERICAN PHYSIOLOGICAL SOCIETY, US, vol. 75, no. 4, 1 October 1995 (1995-10-01), pages 725 - 748, XP002034532, ISSN: 0031-9333
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