Title:
REGULATION OF DIFFERENTIATION INTO DOPAMINERGIC NEURONS BY METALLOPROTEASE
Document Type and Number:
WIPO Patent Application WO/2013/125878
Kind Code:
A1
Abstract:
The present invention relates to: a method for regulating the differentiation of neural stem cells or neural progenitor cells into dopaminergic neurons, comprising the step of increasing or inhibiting the activity of ADAM17 and/or ADAM10 of neural stem cells or neural progenitor cells; and a use of the ADAM17 and/or ADAM10 as an activator or an inhibitor. The method and a composition of the present invention regulate the activity of ADAM17 and/or ADAM10 for neural stem cells or neural progenitor cells so as to allow the amount of dopaminergic neurons in a midbrain region to be increased, thereby treating diseases such as Parkinson's disease caused by the apoptosis of dopaminergic neurons, and inhibit the activity thereof, thereby improving the treatment effect on diseases such as tumors.
Inventors:
BAIK JA-HYUN (KR)
YOON SE HYOUN (KR)
YOON SE HYOUN (KR)
Application Number:
PCT/KR2013/001389
Publication Date:
August 29, 2013
Filing Date:
February 21, 2013
Export Citation:
Assignee:
UNIV KOREA RES & BUS FOUND (KR)
International Classes:
A61K48/00; A61K31/7088; A61K31/7105; A61P25/00; C12N5/079; C12N15/113
Domestic Patent References:
| WO2006064861A1 | 2006-06-22 | |||
| WO2011144901A1 | 2011-11-24 |
Foreign References:
| US20090297507A1 | 2009-12-03 | |||
| US20040247602A1 | 2004-12-09 |
Attorney, Agent or Firm:
LEE, Cheo Young (KR)
이처영 (KR)
이처영 (KR)
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Claims: