Title:
REGULATION OF HUMAN HEMATOPOIETIN RECEPTOR-LIKE PROTEIN
Document Type and Number:
WIPO Patent Application WO2003064469
Kind Code:
A3
Abstract:
Reagents that regulate human hematopoietin receptor-like protein and reagents which bind to human hematopoietin receptor-like gene products can play a role in preventing, ameliorating, or correcting dysfunctions or diseases including, but not limited to, CNS disorders, COPD, cardiovascular disorders, liver disorders, cancer, asthma, and hematological disorders.
More Like This:
Inventors:
SMITH TIMOTHY J (US)
Application Number:
PCT/EP2003/000964
Publication Date:
April 08, 2004
Filing Date:
January 31, 2003
Export Citation:
Assignee:
BAYER HEALTHCARE AG (DE)
SMITH TIMOTHY J (US)
SMITH TIMOTHY J (US)
International Classes:
C07H21/04; C07K14/705; C07K14/715; C12N15/09; C12N15/12; C12P21/06; C12Q1/68; (IPC1-7): C12N15/12; C12N15/66; C12N5/10; C07K14/715; C12P21/02; G01N33/566; A61K38/17
Domestic Patent References:
| WO2001085792A2 | 2001-11-15 | |||
| WO1998031811A1 | 1998-07-23 | |||
| WO2002029060A2 | 2002-04-11 |
Foreign References:
| EP1188830A1 | 2002-03-20 |
Other References:
LARSEN A ET AL: "EXPRESSION CLONING OF A HUMAN GRANULOCYTE COLONY-STIMULATING FACTORRECEPTOR: A STRUCTURAL MOSAIC OF HEMATOPOIETIN RECEPTOR, IMMUNOGLOBULIN, AND FIBRONECTIN DOMAINS", JOURNAL OF EXPERIMENTAL MEDICINE, TOKYO, JP, vol. 172, 1 December 1990 (1990-12-01), pages 1559 - 1570, XP000611514, ISSN: 0022-1007
KRUSE N ET AL: "CONVERSION OF HUMAN INTERLEUKIN-4 INTO A HIGH AFFINITY ANTAGONIST BY A SINGLE AMINO ACID REPLACEMENT", EMBO JOURNAL, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 11, no. 9, 1 September 1992 (1992-09-01), pages 3237 - 3244, XP002045478, ISSN: 0261-4189
RUI H ET AL: "JAK2 ACTIVATION AND CELL PROLIFERATION INDUCED BY ANTIBODY-MEDIATEDPROLACTIN RECEPTOR DIMERIZATION", ENDOCRINOLOGY, BALTIMORE, MD, US, vol. 135, no. 4, 1 October 1994 (1994-10-01), pages 1299 - 1306, XP002044303, ISSN: 0013-7227
BÖNSCH DOMINIKUS ET AL: "Species-specific agonist/antagonist activities of human interleukin-4 variants suggest distinct ligand binding properties of human and murine common receptor gamma chain", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 270, no. 15, 1995, pages 8452 - 8457, XP002268854, ISSN: 0021-9258
BAZAN J F: "HEMOPOIETIC RECEPTORS AND HELICAL CYTOKINES", IMMUNOLOGY TODAY, vol. 11, no. 10, 1990, pages 350 - 354, XP002268855, ISSN: 0167-5699
KRUSE N ET AL: "CONVERSION OF HUMAN INTERLEUKIN-4 INTO A HIGH AFFINITY ANTAGONIST BY A SINGLE AMINO ACID REPLACEMENT", EMBO JOURNAL, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 11, no. 9, 1 September 1992 (1992-09-01), pages 3237 - 3244, XP002045478, ISSN: 0261-4189
RUI H ET AL: "JAK2 ACTIVATION AND CELL PROLIFERATION INDUCED BY ANTIBODY-MEDIATEDPROLACTIN RECEPTOR DIMERIZATION", ENDOCRINOLOGY, BALTIMORE, MD, US, vol. 135, no. 4, 1 October 1994 (1994-10-01), pages 1299 - 1306, XP002044303, ISSN: 0013-7227
BÖNSCH DOMINIKUS ET AL: "Species-specific agonist/antagonist activities of human interleukin-4 variants suggest distinct ligand binding properties of human and murine common receptor gamma chain", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 270, no. 15, 1995, pages 8452 - 8457, XP002268854, ISSN: 0021-9258
BAZAN J F: "HEMOPOIETIC RECEPTORS AND HELICAL CYTOKINES", IMMUNOLOGY TODAY, vol. 11, no. 10, 1990, pages 350 - 354, XP002268855, ISSN: 0167-5699
Download PDF: