Title:
REGULATION OF HUMAN MITOCHONDRIAL DEFORMYLASE
Document Type and Number:
WIPO Patent Application WO2001042431
Kind Code:
A3
Abstract:
Reagents which regulate human mitochondrial deformylase and reagents which bind to human mitochondrial deformylase gene products can be used to regulate cell proliferation, particularly in diseases such as cancer and other forms of neoplasia.
Inventors:
RAMAKRISHNAN SHYAM (US)
Application Number:
PCT/EP2000/012110
Publication Date:
November 01, 2001
Filing Date:
December 01, 2000
Export Citation:
Assignee:
BAYER AG (DE)
RAMAKRISHNAN SHYAM (US)
RAMAKRISHNAN SHYAM (US)
International Classes:
C12N9/80; A61K38/00; (IPC1-7): C12N15/55; A61K38/00; C07K16/40; C12N9/80; C12P21/00; C12Q1/68; G01N33/68
Domestic Patent References:
| WO2000043942A2 | 2000-07-27 | |||
| WO2001016334A2 | 2001-03-08 |
Foreign References:
| EP0911409A2 | 1999-04-28 |
Other References:
DATABASE SWISSPROT SWISSPROT (SWALL); 15 July 1999 (1999-07-15), FRASER C.M. ET AL.: "Polypeptide deformylase (EC 3.5.)", XP002167625
DATABASE EMBL EMBL EMBL:AI859289; 22 July 1999 (1999-07-22), ROBERT STRAUSBERG: "Polypeptide deformylase", XP002167626
DATABASE EMBL EMBL EM_HTG:AC012040; 20 October 1999 (1999-10-20), MUZNY D.M. ET AL, XP002167627
DATABASE EMBL EMBL:MM1239327; 1 June 1997 (1997-06-01), MARRA M. ET AL.: "Polypeptide deformylase", XP002167628
GIGLIONE C. ET AL.: "Peptide deformylase as a target for new generation, broad spectrum antimicrobial agents", MOLECULAR MICROBIOLOGY, vol. 36, no. 6, June 2000 (2000-06-01), pages 1197 - 1205, XP002167624
GIGLIONE C. ET AL: "Identification of eukaryotic peptide deformylases reveals universality of N-terminal protein processing mechanisms", EMBO JOURNAL, vol. 19, no. 21, 1 November 2000 (2000-11-01), pages 5916 - 5929, XP000999120
DATABASE EMBL EMBL EMBL:AI859289; 22 July 1999 (1999-07-22), ROBERT STRAUSBERG: "Polypeptide deformylase", XP002167626
DATABASE EMBL EMBL EM_HTG:AC012040; 20 October 1999 (1999-10-20), MUZNY D.M. ET AL, XP002167627
DATABASE EMBL EMBL:MM1239327; 1 June 1997 (1997-06-01), MARRA M. ET AL.: "Polypeptide deformylase", XP002167628
GIGLIONE C. ET AL.: "Peptide deformylase as a target for new generation, broad spectrum antimicrobial agents", MOLECULAR MICROBIOLOGY, vol. 36, no. 6, June 2000 (2000-06-01), pages 1197 - 1205, XP002167624
GIGLIONE C. ET AL: "Identification of eukaryotic peptide deformylases reveals universality of N-terminal protein processing mechanisms", EMBO JOURNAL, vol. 19, no. 21, 1 November 2000 (2000-11-01), pages 5916 - 5929, XP000999120
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