Title:
REGULATION OF HUMAN SERINE/THREONINE PROTEIN KINASE NEK1
Document Type and Number:
WIPO Patent Application WO2003000873
Kind Code:
A3
Abstract:
Reagents that regulate human serine/threonine protein kinase NEKI and reagents which bind to human serine/threonine protein kinase NEKI gene products can play a role in preventing, ameliorating, or correcting dysfunctions or diseases including, but not limited to, cancer, particularly colon cancer, cardiovascular disorders, CNS disorders, diabetes or COPD.
Inventors:
XIAO YONGHONG (US)
Application Number:
PCT/EP2002/006879
Publication Date:
March 20, 2003
Filing Date:
June 21, 2002
Export Citation:
Assignee:
BAYER AG (DE)
XIAO YONGHONG (US)
XIAO YONGHONG (US)
International Classes:
C12N9/12; E04D3/28; (IPC1-7): C12N9/12; C12N5/10; C12N15/00; C12Q1/68; G01N33/50
Other References:
DATABASE EMBL [online] 27 May 1999 (1999-05-27), KOEHRER ET AL.: "Homo sapiens mRNA; DKFZp564L2416", XP002224532, retrieved from EBI Database accession no. AL050385
DATABASE EMBL [online] 1 October 1996 (1996-10-01), LETWIN ET AL.: "Serine/threonine-protein kinase NEK1 (EC 2.7.1.37)", XP002224533, retrieved from EBI Database accession no. P51954
LETWIN K ET AL: "A MAMMALIAN DUAL SPECIFICITY PROTEIN KINASE NEK1 IS RELATED TO THE NIMA CELL CYCLE REGULATOR AND HIGHLY EXPRESSED IN MEIOTIC GERM CELLS", EMBO JOURNAL, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 11, no. 10, 1992, pages 3521 - 3531, XP002160269, ISSN: 0261-4189
LEE J C ET AL: "INHIBITORS OF SERINE/THEONINE KENASES", CURRENT OPINION IN BIOTECHNOLOGY, LONDON, GB, vol. 6, no. 6, 1995, pages 657 - 661, XP000567263, ISSN: 0958-1669
CHO-CHUNG YOON S: "Antisense oligonucleotide inhibition of serine/threonine kinases: An innovative approach to cancer treatment.", PHARMACOLOGY & THERAPEUTICS, vol. 82, no. 2-3, May 1999 (1999-05-01), pages 437 - 449, XP002224531, ISSN: 0163-7258
DATABASE EMBL [online] 1 October 1996 (1996-10-01), LETWIN ET AL.: "Serine/threonine-protein kinase NEK1 (EC 2.7.1.37)", XP002224533, retrieved from EBI Database accession no. P51954
LETWIN K ET AL: "A MAMMALIAN DUAL SPECIFICITY PROTEIN KINASE NEK1 IS RELATED TO THE NIMA CELL CYCLE REGULATOR AND HIGHLY EXPRESSED IN MEIOTIC GERM CELLS", EMBO JOURNAL, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 11, no. 10, 1992, pages 3521 - 3531, XP002160269, ISSN: 0261-4189
LEE J C ET AL: "INHIBITORS OF SERINE/THEONINE KENASES", CURRENT OPINION IN BIOTECHNOLOGY, LONDON, GB, vol. 6, no. 6, 1995, pages 657 - 661, XP000567263, ISSN: 0958-1669
CHO-CHUNG YOON S: "Antisense oligonucleotide inhibition of serine/threonine kinases: An innovative approach to cancer treatment.", PHARMACOLOGY & THERAPEUTICS, vol. 82, no. 2-3, May 1999 (1999-05-01), pages 437 - 449, XP002224531, ISSN: 0163-7258
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