Title:
REGULATION OF IMMUNE RESPONSES THROUGH SELECTIVE NEURAL ACTIVATION
Document Type and Number:
WIPO Patent Application WO/2023/114892
Kind Code:
A3
Abstract:
Disclosed herein are methods for regulating an immune response using selective activation of neurons in the caudal nucleus of the solitary tract.
Inventors:
ZUKER CHARLES S (US)
JIN HAO (US)
JIN HAO (US)
Application Number:
PCT/US2022/081626
Publication Date:
September 14, 2023
Filing Date:
December 15, 2022
Export Citation:
Assignee:
UNIV COLUMBIA (US)
International Classes:
C07K14/705; A61P25/00; G16B15/30; A61P37/04
Domestic Patent References:
| WO2020239967A1 | 2020-12-03 |
Foreign References:
| US20200246329A1 | 2020-08-06 | |||
| US20180193414A1 | 2018-07-12 |
Other References:
RAMIREZ VALERIE, SWAIN SAMANTHA, MURRAY KAITLIN, REARDON COLIN, : "Neural Immune Communication in the Control of Host-Bacterial Pathogen Interactions in the Gastrointestinal Tract", INFECTION AND IMMUNITY, vol. 88, no. 9, 19 August 2020 (2020-08-19), pages e00928 - 19, XP093092171, DOI: 10.1128/IAI.00928-19
NASSENSTEIN CHRISTINA, KWONG KEVIN, TAYLOR‐CLARK THOMAS, KOLLARIK MARIAN, MACGLASHAN DONALD M., BRAUN ARMIN, UNDEM BRADLEY J.: "Expression and function of the ion channel TRPA1 in vagal afferent nerves innervating mouse lungs", THE JOURNAL OF PHYSIOLOGY, WILEY-BLACKWELL PUBLISHING LTD., GB, vol. 586, no. 6, 15 March 2008 (2008-03-15), GB , pages 1595 - 1604, XP093092173, ISSN: 0022-3751, DOI: 10.1113/jphysiol.2007.148379
NASSENSTEIN CHRISTINA, KWONG KEVIN, TAYLOR‐CLARK THOMAS, KOLLARIK MARIAN, MACGLASHAN DONALD M., BRAUN ARMIN, UNDEM BRADLEY J.: "Expression and function of the ion channel TRPA1 in vagal afferent nerves innervating mouse lungs", THE JOURNAL OF PHYSIOLOGY, WILEY-BLACKWELL PUBLISHING LTD., GB, vol. 586, no. 6, 15 March 2008 (2008-03-15), GB , pages 1595 - 1604, XP093092173, ISSN: 0022-3751, DOI: 10.1113/jphysiol.2007.148379
Attorney, Agent or Firm:
RABINOWITZ, Aaron B. et al. (US)
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