Title:
REGULATION OF NUCLEIC ACID MOLECULE EXPRESSION
Document Type and Number:
WIPO Patent Application WO/2019/074071
Kind Code:
A1
Abstract:
The present invention provides a nucleic acid molecule dimer that includes a first nucleic acid molecule having complementarity with at least part of a target nucleic acid molecule, and a second nucleic acid molecule having complementarity with the first nucleic acid molecule, wherein the first nucleic acid molecule has a linear form, the second nucleic acid molecule has a cyclic form, and the first and second nucleic acid molecules at least partially form a double strand.
Inventors:
MINOMI KENJIRO (JP)
URUSHIHARA NAOKO (JP)
NAKAJIMA YUSUKE (JP)
TANAKA HIROYUKI (JP)
TERADA ERIKA (JP)
URUSHIHARA NAOKO (JP)
NAKAJIMA YUSUKE (JP)
TANAKA HIROYUKI (JP)
TERADA ERIKA (JP)
Application Number:
PCT/JP2018/037975
Publication Date:
April 18, 2019
Filing Date:
October 11, 2018
Export Citation:
Assignee:
NITTO DENKO CORP (JP)
International Classes:
C12N15/113; A61K31/713; A61K48/00; A61P43/00
Domestic Patent References:
| WO2009029688A2 | 2009-03-05 | |||
| WO2010080129A2 | 2010-07-15 | |||
| WO2011103394A2 | 2011-08-25 | |||
| WO2012005368A1 | 2012-01-12 | |||
| WO2006047842A2 | 2006-05-11 | |||
| WO2012170952A2 | 2012-12-13 | |||
| WO2013185116A1 | 2013-12-12 |
Foreign References:
| JP2008099673A | 2008-05-01 | |||
| JPH09509063A | 1997-09-16 | |||
| JP2009511055A | 2009-03-19 | |||
| JP2002525049A | 2002-08-13 | |||
| JP2017197990A | 2017-11-02 |
Other References:
YAMAKAWA, H. ET AL.: "Properties of Nicked and Circular Dumbbell RNA/DNA Chimeric Oligonucleotides Containing Antisense Phosphodiester Oligodeoxynucleotides", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 6, 1998, pages 1025 - 1032, XP027411625
STEPHENSONZAMECNIK, PROC NATL ACAD SCI U S A., vol. 75, no. 1, 1978, pages 285 - 8
ELBASHIR ET AL., NATURE, vol. 411, no. 6836, 2001, pages 494 - 8
YOSHIMURA ET AL., GENE THER., vol. 8, no. 21, 2001, pages 1635 - 42
LI ET AL., PROC NATL ACAD SCI U S A., vol. 103, no. 46, 2006, pages 17337 - 42
JIAOSLACK, EPIGENETICS, vol. 9, no. 1, 2014, pages 27 - 36
GAGLIONEMESSERE, MINI REV MED CHEM., vol. 10, no. 7, 2010, pages 578 - 95
DELEAVEYDAMHA, CHEM BIOL., vol. 19, no. 8, 2012, pages 937 - 54
BRAMSENKJEMS, J. FRONT GENET., vol. 3, 2012, pages 154
DOLINNAYA ET AL., NUCLEIC ACIDS RES., vol. 21, no. 23, 1993, pages 5403 - 7
WANGKOOL, NUCLEIC ACIDS RES., vol. 22, no. 12, 1994, pages 2326 - 33
DOLINNAYA ET AL., NUCLEIC ACIDS RES., vol. 16, no. 9, 1988, pages 3721 - 38
MICURA, CHEM EUR J., vol. 5, no. 7, 1999, pages 2077 - 82
RETTIGBEHLKE, MOL THER., vol. 20, no. 3, 2012, pages 483 - 512
KRAFT ET AL., J PHARM SCI., vol. 103, no. 1, 2014, pages 29 - 52
HONGNAM, THERANOSTICS, vol. 4, no. 12, 2014, pages 1211 - 32
KACZMAREK ET AL., GENOME MED., vol. 9, no. 1, 2017, pages 60
"Remington's Pharmaceutical Sciences", 1990, MACK PUBLISHING CO.
MATSUI ET AL., MOL THER., vol. 24, no. 5, 2016, pages 946 - 55
See also references of EP 3696270A4
STEPHENSONZAMECNIK, PROC NATL ACAD SCI U S A., vol. 75, no. 1, 1978, pages 285 - 8
ELBASHIR ET AL., NATURE, vol. 411, no. 6836, 2001, pages 494 - 8
YOSHIMURA ET AL., GENE THER., vol. 8, no. 21, 2001, pages 1635 - 42
LI ET AL., PROC NATL ACAD SCI U S A., vol. 103, no. 46, 2006, pages 17337 - 42
JIAOSLACK, EPIGENETICS, vol. 9, no. 1, 2014, pages 27 - 36
GAGLIONEMESSERE, MINI REV MED CHEM., vol. 10, no. 7, 2010, pages 578 - 95
DELEAVEYDAMHA, CHEM BIOL., vol. 19, no. 8, 2012, pages 937 - 54
BRAMSENKJEMS, J. FRONT GENET., vol. 3, 2012, pages 154
DOLINNAYA ET AL., NUCLEIC ACIDS RES., vol. 21, no. 23, 1993, pages 5403 - 7
WANGKOOL, NUCLEIC ACIDS RES., vol. 22, no. 12, 1994, pages 2326 - 33
DOLINNAYA ET AL., NUCLEIC ACIDS RES., vol. 16, no. 9, 1988, pages 3721 - 38
MICURA, CHEM EUR J., vol. 5, no. 7, 1999, pages 2077 - 82
RETTIGBEHLKE, MOL THER., vol. 20, no. 3, 2012, pages 483 - 512
KRAFT ET AL., J PHARM SCI., vol. 103, no. 1, 2014, pages 29 - 52
HONGNAM, THERANOSTICS, vol. 4, no. 12, 2014, pages 1211 - 32
KACZMAREK ET AL., GENOME MED., vol. 9, no. 1, 2017, pages 60
"Remington's Pharmaceutical Sciences", 1990, MACK PUBLISHING CO.
MATSUI ET AL., MOL THER., vol. 24, no. 5, 2016, pages 946 - 55
See also references of EP 3696270A4
Attorney, Agent or Firm:
KOBAYASHI Hiroshi et al. (JP)
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